血清NSE、VILIP-1水平与新生儿缺氧缺血性脑病NBNA评分的相关性

doi:10.3969/j.issn.1671-7171.2022.11.019

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Abstract 【Objective】Objective To investigate the correlation between serum specific neuron enolase (NSE), optic vertebrae protein like protein 1 (VILIP-1) levels and neonatal hypoxic-ischemic encephalopathy (HIE) behavioral neurological score (NBNA). 【Methods】 From March 2018 to August 2021, 126 HIE children (observation group) were selected and 83 healthy newborns (control group) were selected.The levels of serum NSE, VILIP-1 and NBNA scores were compared between the two groups and the observation group at 24 h (T₁), 72 h (T₂) and 7 d (T₃) after birth, and the correlation between the levels of serum NSE, VILIP-1 and NBNA scores was analyzed. At the same time, the diagnostic value of serum NSE, VILIP-1 levels in HIE was analyzed. 【Results】The levels of NSE and VILIP-1 in serum of T₁, T₂, T₃ in the observation group were higher than those in the control group, showing a decreasing trend over time. The NBNA score was lower than that in the control group, showing a rising trend over time, with a statistically significant difference (P<0.05). Compared the serum NSE, VILIP-1 levels and NBNA scores at T₁ of children with different disease severity, the serum NSE, VILIP-1 levels showed an upward trend and NBNA scores showed a downward trend with the aggravation of the disease (P<0.05). Pearson correlation coefficient analysis showed that serum NSE, VILIP-1 levels at T₁ were negatively correlated with NBNA scores (r=-0.603, -0.589, both P<0.001). The cut-off values of serum NSE and VILIP-1 in diagnosing HIE at T₁ were 28.36 μg/L,0.61 μg/L respectively, the area under the curve (AUC) was 0.713 and 0.696 respectively. The AUC, sensitivity and specificity of combined diagnosis of HIE and HIE were higher than that of single diagnosis of HIE and HIE (P<0.05). 【Conclusion】The levels of serum NSE and VILIP-1 are closely related to the NBNA score of HIE children, and dynamic monitoring can guide clinical improvement of treatment.

Key words： Hypoxia-Ischemia,Brain Infant,Newborn,Diseases Phosphopyruvate Hydratase/BL Neurocalcin/BL

Received: 13 April 2022

PACS:

R722.1

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	HAN Bo
	MOU Chun-yan

Cite this article:

HAN Bo,MOU Chun-yan. Correlation between Serum NSE, VILIP-1 Levels and NBNA Scores in Neonates with Hypoxic-ischemic Encephalopathy[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1666-1668.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.11.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I11/1666