角蛋白7和p53蛋白与膀胱癌临床病理的相关性及预测复发风险的价值

doi:10.3969/j.issn.1671-7171.2022.11.027

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Abstract 【Objective】 To investigate the correlation of keratin 7 (KRT7) and p53 protein with clinicopathological features and recurrence prediction of bladder cancer. 【Methods】The clinical data of 72 patients with bladder cancer in our hospital were retrospectively analyzed. The expression of KRT7 and p53 protein was measured by immunohistochemical staining,The positive rates of KRT7 and p53 protein in cancer tissues and adjacent tissues were compared between the two groups. The positive rates of KRT7 and p53 protein in different clinical and pathological characteristics were compared as well. The recurrence rate of 3 cases of bladder cancer patients with different expressions of KRT7 and p53 protein was observed. 【Results】The positive rate of KRT7 in cancer tissues was significantly lower than that in adjacent tissues,while the positive rate of p53 protein was significantly higher than that in adjacent tissues (P<0.05).The negative detection rate of KRT7 and the positive detection rate of p53 protein were significantly higher in patients with capsule infiltration,medium-poor differentiation and lymph node metastasis (P<0.05).The 3-year recurrence rates of patients with KRT7 negative and p53 positive bladder cancer were 46.15% and 50.00%,respectively,which were higher than those of KRT7 positive and p53 negative patients. The recurrence rate was 12.12% and 15.00%,the difference was statistically significant (Log-Rank=17.553,12.281,P<0.05). 【Conclusion】p53 protein was highly expressed in bladder cancer tissues,while KRT7 was lowly expressed. The expression level was closely related to histological differentiation,lymph node metastasis and infiltration of membrane.

Key words： Urinary Bladder Neoplasms/PA Keratin-7 Tumor Suppressor Protein p53 Recurrence

Received: 17 May 2022

PACS:

R737.140.4

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	Articles by authors
	FANG Xin-yan
	GU Ying-hui
	SHI Yan-lin

Cite this article:

FANG Xin-yan,GU Ying-hui,SHI Yan-lin. Relationship of Keratin 7 and P53 Protein with Clinicopathological Diagnosis and Recurrence Risk of Bladder Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1694-1697.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.11.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I11/1694

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