Periostin蛋白在食管鳞状细胞癌组织中表达及其与患者临床病理特征的相关性

doi:10.3969/j.issn.1671-7171.2022.11.007

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Abstract 【Objective】 To investigate the expression of Periostin protein in esophageal squamous cell carcinoma and its correlation with the pathological features of patients. 【Methods】 A total of esophageal squamous cell carcinoma tissues (observation group) resected surgically in our hospital were collected, and the corresponding normal esophageal tissues (more than 5 cm from the cancer tissues) adjacent to the cancer were used as the control group. Immunohistochemistry, semi quantitative RT-PCR and Western blot were used to detect the expression of Periostin protein in esophageal squamous cell carcinoma tissues and normal esophageal tissues adjacent to the cancer. Kaplan-Meier survival curve Cox proportional hazard regression model was used to analyze the expression of Periostin protein and its correlation with the prognosis of patients with esophageal squamous cell carcinoma. 【Results】 The high expression rate of Periostin protein in the observation group was 63.6% (75/118), which was significantly higher than that in the control group [27.1% (32/118)]. The difference was statistically significant(χ²=31.614,P<0.001).The value of Periostin mRNA in esophageal squamous cell carcinoma tissues was higher than that in normal esophageal tissues (P<0.05). The value of Periostin/β-actin in normal tissues adjacent to esophageal carcinoma was lower than that in esophageal squamous cell carcinoma (P<0.05). The TNM stage, differentiation degree and lymph node metastasis of esophageal squamous cell carcinoma patients with different Periostin expression levels were statistically significant (P<0.05). The survival rate of patients with low expression of Periostin was significantly higher than that of patients with high expression of Periostin (P<0.05). Logistic multivariate regression analysis showed that the high expression of Priostin was a risk factor affecting the overall survival of patients with esophageal squamous cell carcinoma (P<0.05). 【Conclusion】 The expression of Periostin in esophageal squamous cell carcinoma is related to histological type, TNM stage and lymph node metastasis, which is of great significance in predicting the prognosis of esophageal squamous cell carcinoma.

Key words： Esophageal Neoplasms/PA Carcinoma,Squamous Cell Neoplasm Proteins

Received: 06 April 2022

PACS:

R735.1

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	LI Chao
	XU Xiao-ling
	LI Juan
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Cite this article:

LI Chao,XU Xiao-ling,LI Juan, et al. Expression of Periostin Protein in Esophageal Squamous Cell Carcinoma and Its Correlation with Clinical Pathological Characteristics[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1622-1625.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.11.007 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I11/1622

[1] IDOLAZZI L,RIDOLO E,FASSIO A,et al.Periostin:the bone and beyond[J].Eur J Intern Med,2017,38:12-16.
[2] SÖZMEN M,DEVRIM A K,KABAK Y B,et al.Periostin alters transcriptional profile in a rat model of isoproterenol-induced cardiotoxicity[J].Hum Exp Toxicol,2019,38(2):255-266.
[3] LIU Y,LIU B A.Enhanced proliferation,invasion,and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin[J].World J Gastroenterol,2011,17(21):2674-2680.
[4] MALANCHI I,SANTAMARIA-MARTíNEZ A,SUSANTO E,et al.Interactions between cancer stem cells and their niche govern metastatic colonization[J].Nature,2011,481(7379):85-89.
[5] 刘宇英,魏君丽,江柔,等.食管癌的流行病学及筛查研究进展[J].中华疾病控制杂志,2022,26(7):839-844.
[6] WEI P F,HUANG H,CHEN M X,et al.Influence of tumor location on the prognisis of metastasis of esophageal cancer after radiotherapy bined with chemotherapy and risk factors of the transfer occurring with 3 years[J].China Med,2020,15:898-902.
[7] 武晨,刘维英.骨膜蛋白在特发性肺纤维化发生发展中的作用机制研究进展[J].山东医药,2022,62(20):105-107.
[8] MA H.Periostin promotes colorectal tumorigenesis through integrin-FAK-Src pathway-mediated YAP/TAZ activation[J].Cell Rep,2020,30(3):793-806.
[9] MOSHER D F,JOHANSSON M W,GILLIS M E,et al.Periostin and TGF-β-induced protein:Two peas in a pod?[J].Crit Rev Biochem Mol Biol,2015,50(5):427-439.
[10] NUZZO P V,RUBAGOTTI A,ARGELLATI F,et al.Prognostic value of preoperative serum levels of periostin (PN) in early breast cancer (BCa)[J] Int J Mol Sci,2015,16(8):17181-17192.
[11] LI Z,ZHANG X,YANG Y,et al.Periostin expression and its prognostic value for colorectal cancer[J].Int J Mol Sci,2015,16(6):12108-12118.
[12] AUKKARASONGSUP P,HARUYAMA N,MATSUMOTO T,et al.Periostin inhibits hypoxia-induced apoptosis in human periodontal ligament cells via TGF-beta signaling[J].Biochem Biophys Res Commun,2013,441:126-132.
[13] XU C J,WANG Z Y,ZHANG L,et al.Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway[J].Cancer Cell Int,2022,22(1):34.