Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages Board  |  Contact Us  |  中文

Forthcoming Articles    Current Issue    Archive    Advanced Search    Read Articles    Download Articles    Email Alert

Quick Search     Adv Search 2020 Vol. 37, No. 6 Published: 2020-06-30   810 Risk Factors Analysis of Bronchopulmonary Dysplasia in Very (extremely) Low Birth Weight Premature Infants QI Hua-xue, WU Min, CHEN Tie-qiang, et al DOI: 10.3969/j.issn.1671-7171.2020.06.003 【Objective】To analyze the risk factors of bronchopulmonary dysplasia (BPD) in very (extremely) low birth weight premature infants. 【Methods】A total of 139 premature infants with birth weight less than 1500g were collected from the NICU of Changsha Hospital for Maternal＆Child Health Care, from January 2017 to December 2019. According to whether be diagnosed as BPD, they were divided into the non-BPD group (n=81) and the BPD group (n=58). The differences between the two groups of premature infants in terms of maternal age, chorioamnionitis, gender, gestational age, and birth weight of the children were compared, and independent risk factors for BPD occurrence were analyzed by multivariate logistic regression.【Results】The proportion of mothers with chorioamnionitis and assisted conception in premature infants in the BPD group was higher than that in the non-BPD group, and the difference was statistically significant (P<0.05). The hospital stay of premature infants in the BPD group was higher than that in the non-BPD group. The proportion of males, invasive ventilator use, neonatal respiratory distress syndrome (NRDS), pulmonary surfactant (PS), neonatal pneumonia, and pharyngeal swab UU (ureaplasma urealyticum) positive tests in the BPD group were higher than those in non-BPD groups (P<0.05). Multivariate unconditional logistic regression analysis showed that gestational age and NRDS were the independent high-risk factors of very (extremely) low birth weight preterm infants.【Conclusion】The risk factors related to the development of bronchopulmonary dysplasia (BPD) in very (extremely) low birth weight premature infants were chorioamnionitis, birth weight, gestational age, NRDS, use of invasive ventilation and pharyngeal swab UU positive test. Of which, the gestational age and NRDS were independent risk factors. 2020 Vol. 37 (6): 810-812 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 813 Early Screening Results Analysis of Influencing Factors for Diabetic Retinopathy in Tianxin District of Changsha DENG Li, WEN Wen, MAO Xiao-ting, et al DOI: 10.3969/j.issn.1671-7171.2020.06.004 【Objective】To investigate the early screening analysis of influencing factors for diabetic retinopathy (DR) in Tianxin district of Changsha city.【Methods】The medical records of 465 patients with early screening for diabetic retinopathy in Tianxin district of Changsha city were collected. The general characteristics were statistically analyzed. The influencing factors of DR occurrence were conducted by both binary logistic regression and ordinal multi-nominal logistic regression. 【Results】The average age of patients with early screening for diabetic retinopathy in Tianxin region was 63.3±11.6 years, the average course of disease was 8.3±6.1 years, and the incidence of diabetic retinopathy was 22.3% (104/465). Age and course of disease affected the occurrence of diabetic retinopathy but did not affect the grade of DR. 【Conclusion】Age and course of disease are independent risk factors for the development of diabetic retinopathy. 2020 Vol. 37 (6): 813-815 [Abstract] ( 50 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 816 Expression and Significance of Dysferlin in Serum, Cord Blood and Placenta of Pregnant Women with Pregnancy-induced Hypertension PAN Chang-qing, GAO Ying-chun, YU Wen-liang, et al DOI: 10.3969/j.issn.1671-7171.2020.06.005 【Objective】To investigate the expression and significance of transmembrane protein Dysferlin in serum, cord blood and placental tissue of pregnant women with gestational hypertension. 【Methods】A total of 66 pregnant women with pregnancy-induced hypertension, who were hospitalized in our department from August 2017 to February 2019, were selected and divided into pregnancy-induced hypertension group (22 cases), preeclampsia group (22 cases) and eclampsia group (22 cases) according to the severity of pregnant women. In the same time period, 22 normal pregnant volunteers (full term delivery without complications) were enrolled for the control group. The expression of Dysferlin in serum and umbilical cord blood of the four groups of pregnant women was detected by ELISA. Immunohistochemistry (SP method) was used to detect the expression of Dysferlin in placental tissues of 4 groups. 【Results】Compared to the control group and the gestational hypertension group, Dysferlin expression levels in serum and umbilical cord blood in the pre-eclampsia group and the eclampsia group were significantly reduced, and the differences were statistically significant (P<0.05). In comparison with preeclampsia, Dysferlin expression in serum and umbilical cord blood in the eclampsia group was significantly decreased, and the difference was statistically significant (P<0.05). The results of immunohistochemistry showed that the positive expression rate of Dysferlin in placenta of all four groups were not statistically significant difference (P>0.05). 【Conclusion】The expression of Dysferlin is different depending on the severity of pregnancy-induced hypertension. Clinical monitoring of Dysferlin levels in serum and umbilical cord blood can provide a reference for the diagnosis and treatment of gestational hypertension. 2020 Vol. 37 (6): 816-818 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 819 Influence of COVID-19 on Depression and Anxiety of College Students and Analysis of Related Factors LIU Shi-Ming, YUAN Yuan, LUO Bin DOI: 10.3969/j.issn.1671-7171.2020.06.006 【Objective】To analyze the current status and influential factors of depression and anxiety of college students during the epidemic of Corona Virus Disease 2019(COVID-19). 【Methods】 The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to evaluate the anxiety and depression of 611 undergraduate students in our school: the sociological data of 611 undergraduate students were collected by questionnaire; the factors related to anxiety and depression were analyzed by single factor variance analysis; and the risk factors affecting anxiety and depression were analyzed by multivariate logistic regression analysis.【Results】(1) The total score was (33.46±8.55), the standard score was (41.88±10.57), and the SAS score was (29.78±10.07). According to the results of Chinese norm, the incidence of depression in 611 college students during the prevalence of covid-19 was 16.53% (101/611), of which 52 were mild ,40 were moderate and 9 were severe; the incidence of anxiety was 14.08% (86/611), of which 57 were mild ,24 were moderate and 5 were severe; the incidence of depression with anxiety was 10.64% (65/611). (2) One-way ANOVA showed that: living in Hubei area, family income less than 5000 yuan, senior students, families with COVID-19 patients, introversion, single state, epidemic situation closed management on their own impact degree, attitude to epidemic prevention and control measures had an impact on college students depression (P<0.05); living in Hubei area, monthly income less than 5000, senior students, families with COVID-19 patients, introverted, epidemic situation closed management on their own impact degree, attitude to epidemic prevention and control measures had an impact on college students anxiety (P<0.05). (3) Multivariate logistic regression analysis showed that: living in Hubei (OR=5.024), senior students (OR=7.044), family patients with COVID-19 (OR=4.898), introversion (OR=10.371), closed management of epidemic situation had more influence on themselves (OR=8.768), were risk factors for depression of college students (P<0.05); living in Hubei (OR=6.629), family income below 5000 (OR=3.956),Senior students (OR=5.233), family patients with COVID-19 (OR=21.104), closed management of epidemic situation on their own greater impact (OR=5.895), were risk factors of anxiety for college students(P<0.05).【Conclusion】The prevalence of covid-19 has a negative impact on College Students' depression and anxiety. Positive psychological counseling and reasonable prevention and control measures can help to alleviate the negative emotions of college students. 2020 Vol. 37 (6): 819-823 [Abstract] ( 144 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 824 Application of Human Body Composition Monitor Analysis in Patients with Maintenance Hemodialysis DONG Guan-nan, WANG Kai, YANG Yu-peng, et al DOI: 10.3969/j.issn.1671-7171.2020.06.007 【Objective】To explore the application value of human body composition monitor test in maintenance hemodialysis (MHD) patients. 【Methods】A total of 70 patients with MHD in our hospital were selected and randomly divided into the observation group (n=36) and the control group (n=34). Patients in the observation group received human body composition analysis and targeted-nutrition and health guidance, while patients in the control group received routine nutrition and health education. The serum albumin, pre-albumin and other related parameters in both groups before and after treatment were measured. 【Results】After treatment, the albumin, prealbumin and total protein in the observation group were (39.82±5.44) g/L, (290.78±35.1) mg/L and (67.15 ±12.23) g/L, respectively, which were significantly higher than those in the control group(36.12±5.20)g/L,(266.21±36.40)mg/L and (55.41±11.84)g/L, respectively (P<0.05), while the water ratio in the observation group was (0.37±0.06), which was significantly lower than that in the control group(0.40±0.05) (P<0.05). The serum creatinine, serum phosphorus and calcium-phosphorus multiplier scores in the observation group after treatment were (310.34±90.53) mmol/L, (1.20 ±0.32) mmol/L and (30.49±5.29) mg2/dl2,respectively, which were significantly lower than those in the control group (420.11±99.82)mmol/L,(1.71±0.31)mmol/L and(38.56±6.11)mg2/dl2 (P<0.05), respectively; while serum calcium in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the PG-SGA score of the observation group was (1.87±0.43), which was significantly lower than that of the control group (2.98±0.67)(P<0.05). 【Conclusion】Human body composition monitor has a good application value in MHD patients, which can effectively improve nutritional status of patients. 2020 Vol. 37 (6): 824-826 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 827 Survey on AIDS-related Knowledge, Attitude and Behavior in Students from Three Universities in Changsha HUANG Tao, LI Pei-hui, WU Xing-rong, et al DOI: 10.3969/j.issn.1671-7171.2020.06.008 【Objective】To evaluate the awareness rate of AIDS-related knowledge in students from three universities in Changsha, and to understand the risk prediction ability for AIDS and the incidence of AIDS related behaviors in college students. 【Methods】A random sampling method was used to select students from three universities in Changsha to conduct cross-section anonymous self-filled questionnaires. The survey included college students' awareness of basic AIDS knowledge, transmission routes, prevention, diagnosis and treatment, attitudes to human immunodeficiency virus (HIV) infected persons and AIDS patients, and the impact on the HIV infection risk of personal behavior. SPSS21.0 software was used to process and analyze the data.【Results】AIDS caused by HIV showed the highest awareness rate (93.6%). The overall awareness rate of the surveyed college students about:AIDS was cqused by the HIV was 93.6%. "HIV infected people will definitely develop into AIDS patients" was only 24.7%. The awareness rate of "Can sharing meals with AIDS patients be infected" in men was 89.4%, which was higher than that in women(83.2%). The awareness of "The correct use of condoms can prevent AIDS" was low at 68.6%. Among multiple AIDS related knowledge issues, the awareness rate of non-liberal arts students was significantly higher than that of liberal arts students (P<0.05). However, in the two specific issues, " Willingness to go the hospital to check for STDs after unclean sexual behavior, " and "Willingness to participate in publicity activities of AIDS prevention and control ", the positive willingness of liberal arts students was significantly higher than that of non-liberal arts students (P<0.05). Among the 579 students, 134 of them had sexual intercourse, accounting for 23.1%. 【Conclusion】The overall level of awareness of AIDS among college students in Changsha is about the average level. It is necessary to adopt the targeted education and behavioral intervention measures according to the characteristics of different majors. 2020 Vol. 37 (6): 827-830 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 831 Effect of Butorphanol Tartrate Combined with Sufentanil on Analgesia, Ramsay Score and Adverse Reactions in Patients Undergoing Laparoscopic Total Hysterectomy FANG Jian, LIU Yong-hui, LI Sheng-hua DOI: 10.3969/j.issn.1671-7171.2020.06.009 【Objective】To investigate the effects of butorphanol tartrate combined with sufentanil on analgesia, Ramsay score, and adverse reactions in patients undergoing laparoscopic total hysterectomy( LTH). 【Methods】A total of 78 patients with LTH were enrolled in the study. They were divided into two groups by random method. Patients in the control group (n=39) received sufentanil, while patients in the observation group (n=39) received butorphanol tartrate combined with sufentanil treatment. Both VAS score and Ramsay score at 4 h, 8 h, 12 h, 24 h, 48 h after treatment were evaluated, and adverse drug reactions were compared in both groups as well. 【Results】The VAS scores of both groups had a tendency to decrease with time (P<0.05), and the decreasing trend of the observation group over time was higher than the control group. The VAS scores of the observation group at each time point were significantly lower than those in the control group (P<0.05). The Ramsay score at 4 hours after medication in the observation group was significantly higher than that of the control group (P<0.05), while there were not statistically significant differences between the two groups at other time points (P>0.05). The incidence of adverse reactions in the observation group was 17.95%, (7/39), which was significantly lower than that in the control group 41.03% (16/39). The difference was statistically significant (P<0.05). 【Conclusion】 Butorphanol tartrone combined with sufentanil for LTH has better postoperative analgesia and less adverse reactions, which is worthy of clinical promotion. 2020 Vol. 37 (6): 831-833 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 834 Analysis of Iodine Nutrition with Body Mass Index and Thyroid Related Antibodies in Adolescents in Huizhou PENG Lin-ping, CHEN Li-qiang, LUO Hao-yuan DOI: 10.3969/j.issn.1671-7171.2020.06.010 【Objective】To study the correlation between iodine nutritional status and thyroid related antibody in adolescents in Huizhou. 【Method】A total of 1207 adolescents from 4 high schools in Huizhou were selected randomly in December 2016 and December 2017 respectively, and their urinary iodine concentration, height, weight, serum TSH, FT3, FT4, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), and thyrotrophin receptor antibody (TRAb) were detected. 【Results】The median urinary iodine (MUI) of adolescents was 205.93 μg/L in Huizhou region. There was no significant difference in urinary iodine level between boys and girls(P>0.05, Z=-0.97). Urinary iodine level was positively correlated with TPOAb (R=0.42,P<0.001). Serum TSH level was positively correlated with BMI (R=0.24,P<0.01) . There was no significant difference in urinary iodine level between overweight adolescents and normal BMI population(P>0.05,Z=-0.10). Urinary iodine level was significantly higher in first-degree relatives who have history of hyperthyroidism or hypothyroidism of adolescents(P<0.001,Z=-4.91). 【Conclusion】Urinary iodine levels in adolescents may be associated with thyroid autoimmune diseases,however, it does not affect obesity in adolescents. Urinary iodine concentration monitoring is important to adolescents with thyroid disease clustering families. 2020 Vol. 37 (6): 834-836 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 837 Mediation Effect of Coping Style on Postoperative Social Support and Post-traumatic Growth in Patients undergoing Laparoscopic Cholecystectomy LI Lin, PAN Ru-sheng, Xu Li, et al DOI: 10.3969/j.issn.1671-7171.2020.06.011 【Objective】To investigate the mediating effect of coping style between postoperative social support and post-traumatic growth in patients undergoing laparoscopic cholecystectomy. 【Methods】A total of 212 patients undergoing laparoscopic cholecystectomy were investigated using a cross-sectional survey including general questionnaire, medical response questionnaire, comprehension social support scale and post-traumatic growth scale. 【Results】The total score of post-traumatic growth in patients undergoing laparoscopic cholecystectomy was 67.18±12.28, which was at a medium level. The post-traumatic growth scores in laparoscopic cholecystectomy patients of different genders, ages, education levels, marital status, monthly per capita income, and postoperative complications were different. The differences were statistically significant (P<0.05). The comprehending social support and coping styles were positively correlated with post-traumatic growth (r=0.583, 0.442, P<0.01).Coping style avoidance dimension and yielding dimension were negatively correlated with post-traumatic growth (r=-0.302, -0.314, P<0.01). There was a partial mediating effect of facing and avoiding coping style between comprehending social support and post-traumatic growth. 【Conclusion】Patients with laparoscopic cholecystectomy have moderate post-traumatic growth. Comprehension of social support and coping style are closely related to post-traumatic growth. Coping styles have a partial mediating effect between comprehending social support and post-traumatic growth, so guiding patients to adopt a positive coping style is conducive to improving the level of post-traumatic growth of patients. 2020 Vol. 37 (6): 837-839 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 840 Expression and Significance of Serum miR-152 and miR-32 in Patients with Prostate Cancer DING Ning, ZHANG Zhi-hui, CHENG Wei, et al DOI: 10.3969/j.issn.1671-7171.2020.06.012 【Objective】To investigate the changes of serum miR-152 and mir-32 levels in patients with prostate cancer and their relationship with pathological stage and Gleason score. 【Methods】From January 2016 to may 2018, patients with prostate cancer (observation group,n=80) and patients with prostate hyperplasia (control group,n=80) were selected. The serum levels of miR-152 and miR-32 were detected and compared between the two groups, and stratified analysis was performed according to the pathological stage, PSA and Gleason score. Hierarchical analysis was performed according to pathological staging, PSA and Gleason scores. 【Results】 The level of serum miR-32 in the observation group was significantly higher than that in the control group (P<0.05); the level of serum miR-152 in the observation group was significantly lower than that in the control group (P<0.05). There was significant difference in serum miR-152 level between patients with prostate cancer of different pathological stages and lymph node metastasis (P<0.05); there was no significant difference in serum miR-152 level of prostate cancer patients with different Gleason scores (P>0.05). There were statistically significant differences in serum mir-32 levels among prostate cancer patients with different pathological stages, lymph node metastasis and Gleason score (P<0.05).【Conclusion】 The serum miR-152 level of prostate cancer patients decreased significantly, the miR-32 level increased significantly, and both are closely related to the clinicopathological characteristics of the patients. 2020 Vol. 37 (6): 840-842 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 843 Value of Serum 14-3-3η Protein and anti-CCP Antibody in Diagnosis of Rheumatoid Arthritis WANG Jun-zhe, ZHANG Xiao-rong DOI: 10.3969/j.issn.1671-7171.2020.06.013 【Objective】To explore the diagnostic value of serum 14-3-3ηprotein and anti-cyclic citrullinated peptide (CCP) in rheumatoid arthritis (RA). 【Methods】A total of 40 patients with RA admitted to our hospital were selected as RA group, while 40 healthy persons who underwent physical examination in our hospital during the same period were selected as control group. In addition, 40 patients with non-RA joint disease were selected as non-RA joint disease group. Serum 14-3-3ηprotein, ES,CR,RF and anti-CCP antibody levels were detected in all three groups, and ROC curve was drawn to analyze their diagnostic value for RA. According to the degree of disease activity, RA patients were divided into active group and remission group. Serum 14-3-3 ηprotein and anti-CCP antibody levels were compared between the RA active and remission groups. The ROC curve was drawn to analyze the predictive value on the activity of RA. The area under the curve was obtained, the optimal cutoff value was defined, and the corresponding sensitivity and specificity were calculated. 【Results】Serum levels of 14-3-3ηprotein, anti-CCP antibody, ESR, CRP and RF in the RA group were significantly higher than those in the non-RA group and the control group (P<0.05).The areas under the curve of 14-3-3ηprotein, anti-CCP antibody and 14-3-3ηprotein combined with anti-CCP antibody in the diagnosis of RA were 0.666, 0.712 and 0.781, respectively. Among 40 patients with RA, 25 cases(62.50%) had active phase and 15 cases(37.50%)had remission phase. The levels of 14-3-3ηprotein and anti-CCP antibody in the RA active group were significantly higher than those in RA remission group (P<0.05).The area under the curve of 14-3-3ηprotein, anti-CCP antibody and 14-3-3ηprotein combined with anti-CCP antibody to predict the activity of RA was 0.733, 0.745 and 0.819, respectively. 【Conclusion】Serum 14-3-3ηprotein and anti-CCP antibody have certain value in the diagnosis of RA and the evaluation of disease activity. If necessary, they can be combined for better diagnosis of RA to improve the diagnostic coincidence rate. 2020 Vol. 37 (6): 843-846 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 847 Predictive Value of Combined Detection of mALB, Hcy and NGAL in Acute Cerebral Infarction with Renal Injury GONG Ping, ZHANG Wei, SUN Yi-nan, et al DOI: 10.3969/j.issn.1671-7171.2020.06.014 【Objective】To investigate the predictive value of combined detection of urinary microalbumin (mALB), homocysteine (Hcy) and neutrophil gelatinase associated lipocalin (NGAL) in acute cerebral infarction with renal injury.【Methods】Eighty patients with acute cerebral infarction treated in our hospital from February 2016 to December 2018 were divided into acute cerebral infarction combined with renal injury group (group A,n=47) and simple acute cerebral infarction group (group B,n=33) according to whether renal injury occurred. In addition, 35 healthy physical examinees in our hospital at the same time were selected as control group (Group C). The levels of urine MLB, serum Hcy and NGAL of the three groups were compared, and the positive detection rate of the above indexes on renal injury was analyzed. The correlation between the levels of urine MLB, serum Hcy and NGAL and acute cerebral infarction combined with renal injury was analyzed by linear regression. The predictive value of MLB, Hcy and NGAL on acute cerebral infarction combined with renal injury was analyzed by ROC curve.【Results】Urine mALB, serum Hcy and NGAL levels and positive detection rate in the group A were significantly higher than those in the group B and the group C (P<0.05). Linear regression analysis showed that mALB, Hcy and NGAL levels were significantly correlated with acute cerebral infarction complicated with renal injury (P<0.05). ROC analysis showed that the area under ACU detected by combined detection was larger than that by single detection, and the combined detection could improve the prediction sensitivity and specificity (P<0.05). 【Conclusion】The levels of urine mALB, serum Hcy and NGAL in patients with acute cerebral infarction complicated with renal injury were significantly increased, and they were positively correlated with renal injury. The combined detection of the three indexes has high value in the diagnosis of renal injury. 2020 Vol. 37 (6): 847-850 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 851 Clinical Value of STE in the Assessment of Left Ventricular Function in Patients with STEMI after Selective PCI JIANG Wei, WANG Xi-hui, KANG Xiao-jun DOI: 10.3969/j.issn.1671-7171.2020.06.015 【Objective】To evaluate speckle tracking echocardiography (STE) in judgement of the left ventricular function in patients with acute ST-segment elevation myocardial infarction (STEMI) after selective percutaneous coronary intervention (PCI). 【Methods】From January 2016 to April 2017, 92 STEMI patients (observation group) were selected from our hospital, and 60 patients (excluding coronary artery lesions) who had coronary CTA examination due to chest pain at the same time were selected as the control group. Both groups were given stem examination. The global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and global area strain (GAS) were recorded and compared between the two groups. Left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV) and left ventricular ejection fraction (LVEF) were compared between the two groups.【Results】The GLS, GRS, GCS and gas of the observation group were significantly lower than those of the control group before and 12 months after PCI, and the GLS, GRS, GCS and gas of the observation group were significantly higher than those of the PCI group (P<0.05). LVEDV and LVESV in the observation group were higher than those in the control group before and 12 months after PCI, and LVEF was lower than that in the control group, with statistical significance (P<0.05); LVEDV and LVESV in the observation group were lower than that before PCI, and LVEF was higher than that before PCI, with statistical significance (P<0.05). Pearson correlation analysis showed that GLS, GRS, GCS, GAS and LVEF were significantly positively correlated (r=0.405,0.413,0.387,0.422, respectively, P<0.05).【Conclusion】Spot tracking echocardiography(STE)can be used to evaluate the cardiac function of STEMI patients after PCI, which is worthy of clinical application. 2020 Vol. 37 (6): 851-853 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 854 Effects of Sevilamer Carbonate on HO-1、iPTH、FGF-23 and Calcium and Phosphorus Metabolism in Patients with Chronic Renal Failure Complicated with Hyperphosphatemia WANG Hui, LIU Fang, CHEN Cheng DOI: 10.3969/j.issn.1671-7171.2020.06.016 【Objective】To investigate the effects of sevilamer carbonate on heme oxidase-1(HO-1), fibroblast growth factor 23(FGF-23), whole-segment parathyroid hormone (iPTH) and calcium and phosphorus metabolism in patients with chronic renal failure (CRF) complicated with hyperphosphatemia.【Methods】From July 2015 to January 2017, 70 patients with CRF complicated with hyperphosphatemia in our hospital were selected and divided into control group and observation group according to different treatment methods. The control group was treated with conventional hemodialysis, while the observation group was treated with sevilamer carbonate on the basis of the control group. The levels of HO-1, iPTH, FGF-23, calcium and phosphorus metabolism and clinical efficacy of the two groups before and after treatment were compared.【Results】The total effective rate of the observation group was 91.42%, which was significantly higher than 68.57% of the control group (P<0.05). There was no significant difference in the levels of calcium, phosphorus, HO-1, iPTH and FGF-23 between the two groups before treatment (P>0.05); after treatment, the levels of phosphorus, HO-1, iPTH and FGF-23 in the observation group were significantly lower than those in the control group, and the calcium level was significantly higher than that in the control group, with statistical significance (P<0.05). The incidence of complications in the observation group was 11.43%, which was significantly higher than that in the control group (20.00%), and the difference was not statistically significant (P>0.05) 【Conclusion】Sevilamer carbonate combined with hemodialysis in the treatment of CRF patients with hyperphosphatemia can effectively reduce the levels of HO-1, iPTH and FGF-23, regulate the metabolism of calcium and phosphorus, and have low complications, which is worthy of clinical application. 2020 Vol. 37 (6): 854-856 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 857 Effects of Different Surgical Procedures for Early Cervical Cancer on Maternal and Infant Outcomes in Postoperative Pregnant Women SHI Zi-yun, LI Lian-xiang, WANG Ai-ling, et al DOI: 10.3969/j.issn.1671-7171.2020.06.017 【Objective】 To analyze the maternal and infant outcomes of early cervical cancer pregnant women with different surgical methods. 【Methods】Data of 125 cases of successful pregnancy after early cervical cancer surgery in our hospital from January 2015 to January 2017 were collected, among which 69 cases who underwent LEEP knife cervical electrotomy were set as the LEEP group. While 56 patients who underwent cervical coning resection were included in the coning resection group. Pregnancy outcome, delivery mode, maternal outcomes and neonatal complications were compared between the two groups. 【Results】The proportion of full term birth, preterm birth and abortion in the cervical coring resection group was 64.29%, 14.29% and 21.42%, respectively. While the full-term, preterm and abortion rate in the LEEP group was 66.67%, 14.29%, 18.84%, respectively. The difference was not statistically significant (P>0.05). The rates of postpartum hemorrhage, cervix laceration and total complications in the cervical coring resection group were 18.18%, 15.91% and 43.18%, respectively, which were higher than those of LEEP group 8.93%, 7.14% and 23.21%, respectively (P<0.05). The incidence of premature rupture of membranes, asphyxia and overall adverse outcomes of neonates in the cervical coning resection group was 18.18%, 20.45% and 52.27%,respectively,which was higher than those in the LEEP group 3.57%, 3.57% and 16.07%, respectively,. The difference was statistically significant differences (P<0.05). The cesarean section rate in the cervical coring resction group was 52.27%, which was significantly higher than the 32.15% in the LEEP group, and the difference was statistically significant (P<0.05). 【Conclusion】 LEEP knife electrocervix resection is superior to the cervical coning resection. It improves maternal and infant outcomes of early cervical cancer pregnant women with LEEP. 2020 Vol. 37 (6): 857-859 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 860 Ultrastructural Changes of Gastrointestinal Tract in Rat with Diabetic Gastrointestinal Disorders LIU Dong-yan, YANG Jing DOI: 10.3969/j.issn.1671-7171.2020.06.018 【Objective】To investigate the ultrastructural changes and pathogenesis of gastrointestinal tract in diabetic gastrointestinal disorders. 【Methods】A total of 50 SD rats were randomly divided into the control group (n=25) and the observation group (n=25). Animal model of diabetes combined with gastrointestinal dysfunction in the observation group were established with streptozotocin infection and diet-controlled method. Left ventricular end-diastolic diameter (LVEDD), end-systolic diameter (LVESD), systolic ventricular septal thickness (IVSs), left ventricular posterior wall thickness (LVPWs), and left ventricular ejection fraction(LVEF) were measured by echocardiography.Meanwhile, fasting blood glucose (FPG) levels were determined by blood glucose meter and fasting insulin (FINS) was measured by enzyme-linked immunosorbent assay (ELISA), while insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI) were calculated by steady state model. Finally, rat gastrointestinal tissues of the two groups were taken and the ultrastructural changes were observed by transmission electron microscopy. 【Results】The levels of LVEDD, LVESD,FPG,FINS and HOMA-IR in the observation group were higher than those in the control group (P<0.05). The levels of IVSs, LVPWs, ISI and LVEF in the observation group were lower than those in the control group (P<0.05). The results of transmission electron microscopy showed that the ultrastructure of the gastric antrum and colon in the gastrointestinal tract tissue of laboratory diabetic rats was seen dramatic changes. While the ultrastructure of the small intestine changed relatively strongly. The lesions were mainly focused on smooth muscles and microvessels. No ultrastructural changes occurred in the nerve endings. At the same time, the arrangement of muscle cells was disordered, with larger cytosolic vacuoles within the muscle cells. Overall, no significant abnormalities were observed in the control rats. 【Conclusion】Diabetic rats are often accompanied by blood glucose level disorder and gastrointestinal dysfunction, which may be related to the ultrastructural changes of the gastrointestinal tract. Our research may provide some ideas for the treatment of diabetes. 2020 Vol. 37 (6): 860-862 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 863 Application Value of Tumor Markers Detection in Preoperative Evaluation and Endoscopic Treatment of Gastric Cancer BAI Yan-feng, NAN Jian-dong DOI: 10.3969/j.issn.1671-7171.2020.06.019 【Objective】To investigate the value of tumor markers in preoperative evaluation of gastric cancer and indications for endoscopic treatment. 【Methods】A total of 79 patients with gastric cancer admitted to our hospital from March 2016 to March 2019 was divided into two groups according to the indication of endoscopic submucosal dissection (ESD) (n=38) and not according to the indication of ESD (n=51). Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of serum carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 724 (CA724), alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA), and to analyze the relationship between them and the clinical characteristics of patients, and to analyze the value of each index in ESD.【Results】 The positive rate of CA19-9 was related to TNM stage and lymph metastasis (P<0.05); the positive rate of CA724 was related to TNM stage, depth of invasion and distant metastasis (P<0.05); the positive rate of AFP was related to TNM stage and distant metastasis (P<0.05); the positive rate of CEA was related to TNM stage, depth of invasion and distant metastasis (P<0.05). The levels of CA19-9, CA724 and CEA in the non ESD group were significantly higher than those in the ESD group (P<0.05). ROC curve analysis showed that the difference was statistically significant (Z=4.153, P=0.001;Z=3.375, P=0.029); the difference was not statistically significant (P>0.05) when CA19-9 and CA724 were detected alone, and the sensitivity and specificity of combined detection were better than that of single detection (P<0.05). 【Conclusion】CA19-9, CA724, CEA and AFP detection have certain clinical application value in preoperative evaluation of gastric cancer patients and indications of endoscopic treatment. Combined detection can improve sensitivity and specificity, which is worthy of clinical reference. 2020 Vol. 37 (6): 863-865 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 866 Expression and Significance of MMP-9, MMP-2, MIG-7 and FLNa in Colon Cancer YANG Hua, HOU Jing-fang DOI: 10.3969/j.issn.1671-7171.2020.06.020 【Objective】To investigate the expression of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase 2 (MMP-2), filagin A (FLNa) and migration-inducible protein-7 (MIG-7) in colon cancer and reveal their correlation with clinicopathological factors and prognosis of colon cancer. 【Methods】A total of 120 patients with colon cancer who underwent surgical resection in our hospital were enrolled in the study. The postoperative cancer tissues and adjacent tissues were taken to measure the expression of MMP-9, MMP-2, FLNa and MIG-7 in colon cancer by immunohistochemical examination. Meanwhile their relationship with clinical pathological factors and prognosis were analyzed as well. 【Results】 The positive rates of MMP-9, MMP-2 and MIG-7 in cancer tissues were higher than those in adjacent tissues,while the positive rate of FLNa in cancer tissues was lower than that in adjacent tissues (P<0.05). The lymph node metastasis rate, phase Ⅲ ratio, vascular infiltration rate, and middle and low differentiation rate of MMP-9, MMP-2, and MIG-7 positive patients were higher than those with negative expression patients(P<0.05), however, the lymph node metastasis rate, phase Ⅲ ratio, vascular infiltration rate, and middle and low differentiation rate of FLNa positive patients were lower than those with negative expression patients (P<0.05). The median follow-up time was 26 months and 22 patients died. COX multivariate analysis showed that TNM stage, FLNa, MIG-7, MMP-2, MMP-9, tumor differentiation, and lymph node metastasis were independent factors of survival (P<0.05). 【Conclusion】MMP-9, MMP-2 and MIG-7 are highly expressed in colon cancer tissues, and FLNa is lowly expressed in colon cancer tissues. The expressions of FLNa, MIG-7, MMP-2 and MMP-9 are associated with tumor invasion and prognosis. 2020 Vol. 37 (6): 866-869 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 870 Effect of Radial Axial Incision on Corneal Astigmatism after Phacoemulsification ZHANG Hong, CHEN Ying-ping, CHEN Sheng-wen DOI: 10.3969/j.issn.1671-7171.2020.06.021 【Objective】To explore the effect of radial axial incision on corneal astigmatism after ultrasonic phacoemulsification. 【Methods】A total of 60 cases (with 62 eyes) of cataract patients were selected from July 2017 to November 2015 in our hospital for the study. Patients were divided into the group A and group B randomly, with 30 cases in each group. Both groups received a corneal incision in the certain part of cornea. The incision of the group A was at the maximum corneal refractive radial axial and the incision of the group B was at the traditional temporal side (right eye) or nasal side (left eye). At the same time, patients in the two groups had ultrasonic phacoemulsification and foldable intraocular lens implantation. The astigmatism and axial direction of patients were measured by CT200 corneal topography before the surgery and after the surgery (at 1 day, 1 week and 1 month). The surgically derived astigmatism was calculated according to the corneal astigmatism and axial direction. Then, the data of corneal astigmatism, surgically induced astigmatism and visual acuity were compared between the two groups. 【Results】Postoperative visual acuity was significantly improved in the two groups (P<0.05), while there was no statistically significant difference in visual acuity between the two groups at 1 day, 1 week and 1 month after the operation (P>0.05). The corneal astigmatism of the two groups was not statistically significant at 1 day after surgery (P>0.05), while the corneal astigmatism in group A at 1 week and 1 month after surgery was significantly less than that in group B, and the difference was statistically significant (P<0.05). At 1 week and 1 month after surgery, the surgically derived astigmatism in group A was significantly lower than in group B(P<0.05). 【Conclusion】The incision at the maximum curvature of the cornea i.e. radial axial incision in cataract surgery can significantly reduce the corneal astigmatism and surgically derived astigmatism,which has good clinical application value. 2020 Vol. 37 (6): 870-872 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 873 Effect of Intermittent Occlusion Combined with Visual Perceptual Learning on Amblyopia in Children WEI Fen, XIAO Xiu-lan DOI: 10.3969/j.issn.1671-7171.2020.06.022 【Objective】To explore the clinical effect of intermittent occlusion combined with visual perceptual learning on amblyopia in children.【Methods】Eighty cases of amblyopia in our hospital from January 2016 to January 2018 were randomly divided into observation group and control group, 40 cases in each group. The control group was treated with intermittent occlusion, and the observation group was treated with visual perception learning on the basis of the control group. The visual improvement of the two groups before treatment and after 3 months, 6 months, 12 months were compared.【Results】The basic cure rate of the observation group was better than that of the control group, the difference was statistically significant (P<0.05); there was no statistically significant difference in BCVA between the two groups before and 3 months after treatment (P>0.05), and the BCVA of the observation group was better than that of the control group at 6 and 12 months after treatment, the difference was statistically significant (P<0.05); the best corrected visual acuity of the observation group increased by (1.00±0.40) lines on average during 3-6 months of treatment, which was better than that of the control group (0.70±0.30). The difference was statistically significant (P<0.05); after treatment, the stereopsis of both groups was improved. The proportion of people whose stereopsis recovery≤60″ in the observation group was better than that in the control group, and the difference between the two groups was statistically significant (P<0.05).【Conclusion】Intermittent occlusion combined with visual perceptual learning can improve the corrected visual acuity of children with amblyopia and improve the cure rate. It is worthy of clinical application. 2020 Vol. 37 (6): 873-875 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 876 Correlation of Serum 25(OH)D3 Level with Acute Asthma Severity and Related Indicators LIU Yi-Jun, LIU Xiang DOI: 10.3969/j.issn.1671-7171.2020.06.023 【Objective】To explore the relationship of serum 25(OH)D3 level with disease severity and related indexes in patients acute asthma. 【Methods】A total of 72 patients with acute asthma diagnosed and treated in the Department of Respiratory Medicine in our hospital from March 2016 to February 2018 were enrolled as the observation group. According to the severity of asthma, patients in the observation group were further divided into three sub-groups, including 18 cases in the mild group, 28 cases in the moderate group, and 26 cases in the severe group. At the same time, 53 healthy volunteers in our physical examination center were selected as the control group. Serum 25-hydroxyvitamin D3(25(OH)D3) levels, high-sensitivity C-reactive protein (Hs-CRP) levels, serum calcium, serum inorganic phosphorus, and serum alkaline phosphatase were measured. Pulmonary function tester was used to measure the forced expiratory volume in one second of asthma patients as a percentage of the predicted value (FEV1%). The correlation of serum 25(OH)D3 level with disease severity and related indexes in acute asthma patients was explored. 【Results】The 25(OH)D3 level in the observation group was significantly lower than that in the control group (P<0.05), and the Hs-CRP level in the observation group was significantly higher than that in the control group (P<0.05). The levels of both FEV1% and 25(OH)D3 in the mild group, moderate group and severe group decreased in turn (P<0.05), while the Hs-CRP levels in the mild group, moderate group and severe group increased in sequence(P<0.05). The differences were statistically significant (P<0.05). Pearson correlation analysis showed that 25(OH)D3 in the observation group was positively correlated with FEV1% (r=0.755, P<0.05) and negatively correlated with Hs-CRP (r=-0.804, P<0.05). 【Conclusion】The serum 25(OH)D3 level in patients with acute asthma is inversely proportional to the severity of the disease, namely the more severe the condition, the lower the 25(OH)D3 level. At the same time, it is positively correlated with FEV1% value and negatively correlated with serum hs-CRP. The lower the serum 25(OH)D3 level, the worse the lung function in patients with acute asthma and the more likely to induce inflammation. 2020 Vol. 37 (6): 876-878 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 879 Value of N-terminal Pro-brain Natriuretic Peptide and Uric Acid in Differential Diagnosis of Acute Pulmonary Thromboembolism and Congestive Heart Failure ZHOU Hong-li, ZHONG Sheng-nian, BAO Hai-yong DOI: 10.3969/j.issn.1671-7171.2020.06.024 【Objective】To investigate the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and uric acid in the differential diagnosis of acute pulmonary thromboembolism (APE) and congestive heart failure (CHF). 【Methods】 A total of 93 APE patients and 167 CHF patients admitted to our hospital were selected. Then the NT-proBNP levels were measured by electrochemiluminescence immunoassay, meanwhile the uric acid levels were analyzed by an automated biochemical analyzer. Thereafter, the differences in the levels of the two indicators between APE and CHF was analyzed, and the ROC curve was explored the differential diagnosis value for APE and CHF. 【Results】The levels of NT-proBNP and uric acid in patients with APE were significantly lower than those in CHF group, the difference was statistically significant (P<0.05). The AUC of NT-proBNP was 0.893, the AUC of uric acid was 0.762, and the AUC of NT-proBNP combined with uric acid was 0.924. Different truncation points were selected to evaluate the application in APE. If NT-proBNP =1799.0 pg/mL combined with uric acid =281.0 μmol/L, the APE sensitivity and specificity were 21.3% and 98.9% respectively. If NT-proBNP=5981.0 pg/mL parallel uric acid=569.0 μmol/L the APE sensitivity was 99.3% and the specificity was 19.6%. 【Conclusion】NT-proBNP and uric acid can be used as reliable and sensitive indicators to apply differential diagnosis of APE and CHF,which have high clinical application value. 2020 Vol. 37 (6): 879-881 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 882 Dynamic Monitoring of Immune-related Indicators to Assess Immune Function and Predict Disease Severity and Outcome in Critically Ill Patients TAO Dan, LI Peng DOI: 10.3969/j.issn.1671-7171.2020.06.025 【Objective】To investigate the value of dynamic monitoring of immune-related indexes to evaluate immune function and predict disease severity and outcome in the critically ill patients. 【Methods】A total of 53 patients admitted to EICU of our hospital were selected in this study. According to the 28-day mortality, patients were divided into two groups: the survival group (n=36) and the death group (n=17). The peripheral venous blood on the 1st, 3rd, and 7th day after admission were collected for the inflammation indicators detection including interleukin-6 (IL-6),IL-8 and IL-10 and TNF-α, as well as the immunologically relevant indicators detection including PCT, hs-CRP, immunoglobulin (IgA, IgM, IgG), CD4+, CD8+, CD4+/CD8+. The patients' immune-related indicators were analyzed to assess critical immune function and predict the severity and outcome of the disease. 【Results】The IL-10 level in the survival group on the 3rd day of EICU was significantly lower than that in the death group (P<0.05). On the 7th day, the survival group had lower PCT level and higher levels of IL-6 and IL-8 than those of the death group (P<0.05). The levels of IgA, IgM and CD8+ in the survival group on the 1st day were significantly lower than those in the death group (P<0.05). The levels of CD4+ and CD4+/CD8+ on the 7th day in the survival group were significantly higher than those in the death group (P<0.05). The sensitivity and specificity of PCT (7th day), IL-10 (3rd day), CD8+, APACHE Ⅱ (acute physiology and chronic health status scoring system) score and SOFA (systemic infection-related organ failure evaluation system) score in the diagnosis of 28-day mortality in critically ill patients were relatively high (P<0.05). 【Conclusion】The immune dysfunction degree is negatively correlated with the prognosis of critically ill patients, which will increase the mortality rate. PCT, IL-10, and CD8+ can predict the risk of the poor prognosis and mortality. 2020 Vol. 37 (6): 882-885 [Abstract] ( 50 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 886 Analysis of the Accuracy and Influencing Factors of MRI in the Diagnosis of Cervical Lymph Node Tuberculosis CHEN Lu, TANG Chen-hu, XUE Jian, et al DOI: 10.3969/j.issn.1671-7171.2020.06.026 【Objective】To observe the accuracy of MRI in the diagnosis of cervical lymph node tuberculosis, and to analyze the factors affecting the accuracy of diagnosis. 【Methods】From February 2017 to may 2018, the clinical data of 200 patients with cervical lymph node tuberculosis who underwent CT and MRI neck examination were selected to compare the accuracy, specificity and sensitivity of the two methods, and the factors influencing the accuracy of MRI examination results were analyzed.【Results】MRI scan showed that the space between the lymph node and the surrounding fat caused by cheese like necrosis of lymph nodes was clear and recognizable, and the pathological changes of lymph nodes could be clearly displayed; CT showed low and equihybrid density images, with clear boundary. When the tuberculous granulation tissue and lymph node were necrotic, MRI and CT images were obvious. The accuracy of MRI in the diagnosis of cervical lymph node tuberculosis was 90.00% (180/200), which was significantly higher than that of CT in 75.00% (150/200). The difference was statistically significant (χ2=15.585, P<0.001). The positive predictive value of MRI in patients with cervical lymph node tuberculosis was higher than that of CT, the difference was statistically significant (P<0.01), but the difference was not statistically significant (P>0.05). The accuracy of MRI diagnosis was higher in patients with multiple nodal tuberculosis and diameter ≥2 cm (P<0.01). Multivariate logistic regression analysis showed that tuberculous diameter was an independent risk factor (OR=5.238, P<0.05).【Conclusion】 The accuracy of MRI in the diagnosis of cervical lymph node tuberculosis is higher than that of CT, and the accuracy of diagnosis is affected by the diameter of the nodule. 2020 Vol. 37 (6): 886-888 [Abstract] ( 91 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 889 Clinical Effect of Trimetazidine in the Treatment of Hypertensive Heart Disease and its Effect on the Level of Oxidative Stress Index ZHANG Na, LIU Xia, WANG Guo-wei DOI: 10.3969/j.issn.1671-7171.2020.06.027 【Objective】 To investigate the clinical effect of trimetazidine on hypertensive heart disease and its effect on oxidative stress index level.【Methods】Eighty-eight patients with hypercardiac disease were selected and divided into control group (routine antihypertensive, lipid-lowering, antiplatelet or anticoagulant therapy,n=48) and observation group (combined with trimetazidine on the basis of control group,n=40). The clinical effects and the changes of cardiac function (LVEF, LVESD, LVDD, LAD), oxidative stress (SOD, MDA, ROS) were compared between the two groups.【Results】The total effective rate of observation group was 90.00% (36/40), which was higher than that of control group (68.75%) (33/48). The difference was statistically significant (χ2=7.940,P=0.005<0.05). After treatment, the LVEF level of the two groups was higher than that before treatment, and the levels of LVESD, lad and LVDD were lower than those before treatment, and the differences between the two groups were statistically significant (mean P<0.05). After treatment, the serum SOD level of the two groups was higher than that before treatment, the MDA and ROS levels were lower than that before treatment, and the difference between the two groups was statistically significant (mean P<0.05). 【Conclusion】Trimetazidine can effectively assist in the treatment of high heart disease, improve the heart function of patients, and reduce the oxidative stress response of patients, which is worthy of clinical reference. 2020 Vol. 37 (6): 889-891 [Abstract] ( 50 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 892 Influence of Preoperative Risk Assessment and Symptomatic Nursing on the Operation Safety and Prognosis Recovery of Elderly Patients with Complicated Inguinal Hernia YU Sai-fen DOI: 10.3969/j.issn.1671-7171.2020.06.028 【Objective】To explore the effect of preoperative risk assessment and symptomatic nursing on the safety of operation and the recovery of prognosis in the elderly patients with complicated inguinal hernia.【Methods】From January 2016 to December 2019, 88 elderly patients with complex inguinal hernia were selected and divided into control group (routine operation nursing) and observation group (routine operation nursing + preoperative risk assessment and symptomatic Nursing) according to the random table method, 44 cases in each group. The recovery of gastrointestinal function and improvement of quality of life were compared between the two groups, and the incidence of complications and recurrence rate were recorded. 【Results】The anal exhaust time, bowel sounds recovery time, postoperative eating time and gastrointestinal peristalsis start time in the control group were longer than those in the observation group (P<0.05). The total incidence of complications in the control group was 27.27% (12/44), significantly higher than that in the observation group (13.64%) (6/44), the difference was statistically significant (χ2=5.709,P=0.017<0.05).The recurrence rate in the control group was 15.91% (7/44), which was significantly higher than 4.55%(2/44) in the observation group, and the difference was statistically significant (χ2=7.026,P=0.008<0.05). The total score SF-36 the quality of life scale in the control group was (70.11±3.25), which was significantly lower than that in the observation group (79.82±5.18), and the difference was statistically significant (t=10.533, P<0.05).【Conclusion】The results of preoperative risk assessment and symptomatic nursing for the elderly patients with complicated inguinal hernia operation are better, with fewer complications and high safety, which is worthy of clinical application. 2020 Vol. 37 (6): 892-894 [Abstract] ( 52 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 895 Application of Uterine Artery Embolization Combined with Methotrexate, Ethacridine and Mifepristone in Induction of Labor in Late Complete Placenta Previa WANG Jing, LU Ying, YANG Xue-qin DOI: 10.3969/j.issn.1671-7171.2020.06.029 Guide::null 【Objective】To investigate the effect of uterine artery embolization combined with methotrexate, ethacridine and mifepristone in induced labor of pregnant women with complete placenta previa. 【Methods】The clinical data of 93 pregnant women with complete placenta previa induced labor in our hospital from March 2014 to March 2018 were retrospectively analyzed. According to the different treatment methods, they were divided into control group and observation group. The control group was induced by bilateral uterine artery embolization combined with ethacridine and mifepristone; the observation group was induced by methotrexate on the basis of the control group. The time of labor, the amount of bleeding during labor, the amount of postpartum hemorrhage, hospitalization time, lochia time, menstrual recovery time, success rate of induced labor, hysterectomy rate, curettage rate and postoperative complications were compared between the two groups. 【Results】The amount of intrapartum hemorrhage, postpartum hemorrhage and hospitalization time in the observation group were significantly lower than those in the control group (P<0.05); however, there was no significant difference in the labor time, lochia duration, menstrual recovery time, induced labor success rate, hysterectomy rate and uterine curettage rate between the two groups (P>0.05). The total incidence of postoperative complications in the observation group was 23.33%, which was not significantly different from 24.24% in the control group (P>0.05). 【Conclusion】Uterine artery embolization combined with methotrexate, ethacridine and mifepristone in the induction of labor of late complete placenta previa can reduce the amount of bleeding during labor and postpartum, shorten the hospitalization time, and does not increase the incidence of adverse reactions and complications, which is worthy of clinical application. 2020 Vol. 37 (6): 895-897 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 898 Therapeutic Effect of Meglumine Adenosine Cyclophosphat Combined with Musk Baoxin Pill on the Treatment of Chronic Pulmonary Heart Disease with Heart Failure LIU Xue-jiao DOI: 10.3969/j.issn.1671-7171.2020.06.030 【Objective】To observe the efficacy of meglumine adenosine cyclophosphat combined with musk Baoxin pill on the treatment of chronic pulmonary heart disease with heart failure. 【Methods】A total of 110 patients with chronic pulmonary heart disease and heart failure were enrolled. According to the random number table method, the patients were divided into the observation group (55 cases, with treatment of meglumine adenosine cyclophosphat combined with musk Baoxin pill) and the control group (55 cases, with meglumine adenosine cyclophosphat treatment only). Lung function indexes (FEV1, FEV1/FVC), blood gas analysis indexes (SaO2, PaO2), cardiac function indicators (LVEF, LVD, CO, LVS) before and after treatment were analyzed. The efficacy, occurrence of adverse drug reactions, and the mortality within 14 days were observed. 【Results】The total effective rate of the observation group at the end of treatment was 96.36%, which was higher than that of the control group (83.64%), the difference was statistically significant (χ2=4.946,P=0.026). After treatment, the parameters of SaO2, PaO2, FEV1 and FEV1/FVC in the two groups were higher than those before treatment. Of which, the SaO2, PaO2 in the control group were higher than those in the observation group; and the difference was statistically significant (P<0.05). However, there were no significant differences in FEV1 and FEV1/FVC between the two groups after treatment (P>0.05). The LVEF of the control group after the treatment was higher than that before treatment, while both LVD and LVS of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions and mortality rate between the control group and the observation group (P>0.05). 【Conclusion】Meglumine adenosine cyclophosphat combined with musk Baoxin pill has good clinical effect on the treatment of chronic pulmonary heart disease with heart failure, which improves the cardiac function and blood gas analysis indicators and reduces pulmonary artery pressure safely. 2020 Vol. 37 (6): 898-900 [Abstract] ( 87 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 901 Relationship between Annexin A2, HMGB1 Protein Expression and Pathological Grade of Gliomas and Seizure MEI Jin, YU Lu, WANG Bin, et al DOI: 10.3969/j.issn.1671-7171.2020.06.031 【Objective】To investigate the relationship between the expression of annexin A2 and HMGB1 and the pathological grade of gliomas and seizures. 【Methods】Eighty glioma tissue samples (observation group) and 40 surgical tissues (control group) were collected from the pathology center of our hospital. The expression of annexin A2 and HMGB1 protein in the two groups were detected by immunohistochemical staining, and the differences of annexin A2 and HMGB1 protein expression in patients with different histological grades, seizure frequency and seizure time were analyzed.【Results】The positive rates of annexin A2 protein and HMGB1 protein in the observation group were significantly higher than those in the control group (χ2=22.097,P<0.05;χ2=26.167,P<0.05). There was no significant difference in the positive expression rate of annexin A2 protein among the patients with different pathological grades in the observation group (P<0.05). The positive expression rate of HMGB1 protein in different pathological grades, seizure frequency and duration of epilepsy in the observation group was statistically significant (P<0.05).【Conclusion】The positive expression rate of annexin A2 and HMGB1 protein in the lesions of glioma patients increased significantly; overexpression of annexin A2 protein and HMGB1 protein is related to the increase of malignant degree of glioma and seizure. 2020 Vol. 37 (6): 901-903 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 904 Comparison of MRI Scan Sequences in the Diagnosis of Achilles Tendon Tears PENG Guang-ming, GE Shang DOI: 10.3969/j.issn.1671-7171.2020.06.032 【Objective】To investigate the diagnostic value of different MRI sequences in closed Achilles tendon tears.【Methods】From January 2016 to January 2019, 150 patients with suspected closed rupture of Achilles tendon were selected. All patients were examined with MRI in our hospital. According to the different MRI sequences, the diagnostic value of T2WI+T1WI+ SPAIR、T2WI+ T1WI+STIR in closed Achilles tendon tears was analyzed and compared. 【Results】Of the 150 patients, 96 were diagnosed as closed Achilles tendon tear. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of T1WI+T2WI +STI were 91.67%, 66.67%, 82.67%, 83.02% and 81.82% respectively; the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of T1WI+T2WI +STIR were 95.83%, 85.19%, 92.00%, 92.00% and 92.00% respectively. There was no significant difference in sensitivity, specificity, positive predictive value and negative predictive value between T1WI+T2WI +STIR and T1WI+T2WI +SPAIR (P>0.05); the accuracy of T1WI+T2WI +SPAIR was 92.00%, significantly higher than 81.82% of T1WI+T2WI+STIR (P<0.05).【Conclusion】MRI has a good application value in the diagnosis of closed Achilles tendon tears, among which T1WI+T2WI +SPAIR sequence has a higher accuracy in the diagnosis of Achilles tendon tears, which is worthy of clinical reference. 2020 Vol. 37 (6): 904-906 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )

Copyright © Editorial Board of JOURNAL OF CLINICAL RESEARCH Supported by:Beijing Magtech