Abstract 【Objective】To investigate the expression and significance of transmembrane protein Dysferlin in serum, cord blood and placental tissue of pregnant women with gestational hypertension. 【Methods】A total of 66 pregnant women with pregnancy-induced hypertension, who were hospitalized in our department from August 2017 to February 2019, were selected and divided into pregnancy-induced hypertension group (22 cases), preeclampsia group (22 cases) and eclampsia group (22 cases) according to the severity of pregnant women. In the same time period, 22 normal pregnant volunteers (full term delivery without complications) were enrolled for the control group. The expression of Dysferlin in serum and umbilical cord blood of the four groups of pregnant women was detected by ELISA. Immunohistochemistry (SP method) was used to detect the expression of Dysferlin in placental tissues of 4 groups. 【Results】Compared to the control group and the gestational hypertension group, Dysferlin expression levels in serum and umbilical cord blood in the pre-eclampsia group and the eclampsia group were significantly reduced, and the differences were statistically significant (P<0.05). In comparison with preeclampsia, Dysferlin expression in serum and umbilical cord blood in the eclampsia group was significantly decreased, and the difference was statistically significant (P<0.05). The results of immunohistochemistry showed that the positive expression rate of Dysferlin in placenta of all four groups were not statistically significant difference (P>0.05). 【Conclusion】The expression of Dysferlin is different depending on the severity of pregnancy-induced hypertension. Clinical monitoring of Dysferlin levels in serum and umbilical cord blood can provide a reference for the diagnosis and treatment of gestational hypertension.
2020, Vol. 37 
