Abstract 【Objective】To investigate the mediating effect of coping style between postoperative social support and post-traumatic growth in patients undergoing laparoscopic cholecystectomy. 【Methods】A total of 212 patients undergoing laparoscopic cholecystectomy were investigated using a cross-sectional survey including general questionnaire, medical response questionnaire, comprehension social support scale and post-traumatic growth scale. 【Results】The total score of post-traumatic growth in patients undergoing laparoscopic cholecystectomy was 67.18±12.28, which was at a medium level. The post-traumatic growth scores in laparoscopic cholecystectomy patients of different genders, ages, education levels, marital status, monthly per capita income, and postoperative complications were different. The differences were statistically significant (P<0.05). The comprehending social support and coping styles were positively correlated with post-traumatic growth (r=0.583, 0.442, P<0.01).Coping style avoidance dimension and yielding dimension were negatively correlated with post-traumatic growth (r=-0.302, -0.314, P<0.01). There was a partial mediating effect of facing and avoiding coping style between comprehending social support and post-traumatic growth. 【Conclusion】Patients with laparoscopic cholecystectomy have moderate post-traumatic growth. Comprehension of social support and coping style are closely related to post-traumatic growth. Coping styles have a partial mediating effect between comprehending social support and post-traumatic growth, so guiding patients to adopt a positive coping style is conducive to improving the level of post-traumatic growth of patients.