Value of N-terminal Pro-brain Natriuretic Peptide and Uric Acid in Differential Diagnosis of Acute Pulmonary Thromboembolism and Congestive Heart Failure
ZHOU Hong-li, ZHONG Sheng-nian, BAO Hai-yong
Affiliated Hospital of Qinghai University emergency center EICU,Qinghai Xining 810001
Abstract 【Objective】To investigate the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and uric acid in the differential diagnosis of acute pulmonary thromboembolism (APE) and congestive heart failure (CHF). 【Methods】 A total of 93 APE patients and 167 CHF patients admitted to our hospital were selected. Then the NT-proBNP levels were measured by electrochemiluminescence immunoassay, meanwhile the uric acid levels were analyzed by an automated biochemical analyzer. Thereafter, the differences in the levels of the two indicators between APE and CHF was analyzed, and the ROC curve was explored the differential diagnosis value for APE and CHF. 【Results】The levels of NT-proBNP and uric acid in patients with APE were significantly lower than those in CHF group, the difference was statistically significant (P<0.05). The AUC of NT-proBNP was 0.893, the AUC of uric acid was 0.762, and the AUC of NT-proBNP combined with uric acid was 0.924. Different truncation points were selected to evaluate the application in APE. If NT-proBNP =1799.0 pg/mL combined with uric acid =281.0 μmol/L, the APE sensitivity and specificity were 21.3% and 98.9% respectively. If NT-proBNP=5981.0 pg/mL parallel uric acid=569.0 μmol/L the APE sensitivity was 99.3% and the specificity was 19.6%. 【Conclusion】NT-proBNP and uric acid can be used as reliable and sensitive indicators to apply differential diagnosis of APE and CHF,which have high clinical application value.
ZHOU Hong-li,ZHONG Sheng-nian,BAO Hai-yong. Value of N-terminal Pro-brain Natriuretic Peptide and Uric Acid in Differential Diagnosis of Acute Pulmonary Thromboembolism and Congestive Heart Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(6): 879-881.
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2020, Vol. 37 
