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| Value of Serum 14-3-3η Protein and anti-CCP Antibody in Diagnosis of Rheumatoid Arthritis |
| WANG Jun-zhe, ZHANG Xiao-rong |
| Clinical Laboratory Chongqing Three Gorges Central Hospital Chongqing Three Gorges 404000 |
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Abstract 【Objective】To explore the diagnostic value of serum 14-3-3ηprotein and anti-cyclic citrullinated peptide (CCP) in rheumatoid arthritis (RA). 【Methods】A total of 40 patients with RA admitted to our hospital were selected as RA group, while 40 healthy persons who underwent physical examination in our hospital during the same period were selected as control group. In addition, 40 patients with non-RA joint disease were selected as non-RA joint disease group. Serum 14-3-3ηprotein, ES,CR,RF and anti-CCP antibody levels were detected in all three groups, and ROC curve was drawn to analyze their diagnostic value for RA. According to the degree of disease activity, RA patients were divided into active group and remission group. Serum 14-3-3 ηprotein and anti-CCP antibody levels were compared between the RA active and remission groups. The ROC curve was drawn to analyze the predictive value on the activity of RA. The area under the curve was obtained, the optimal cutoff value was defined, and the corresponding sensitivity and specificity were calculated. 【Results】Serum levels of 14-3-3ηprotein, anti-CCP antibody, ESR, CRP and RF in the RA group were significantly higher than those in the non-RA group and the control group (P<0.05).The areas under the curve of 14-3-3ηprotein, anti-CCP antibody and 14-3-3ηprotein combined with anti-CCP antibody in the diagnosis of RA were 0.666, 0.712 and 0.781, respectively. Among 40 patients with RA, 25 cases(62.50%) had active phase and 15 cases(37.50%)had remission phase. The levels of 14-3-3ηprotein and anti-CCP antibody in the RA active group were significantly higher than those in RA remission group (P<0.05).The area under the curve of 14-3-3ηprotein, anti-CCP antibody and 14-3-3ηprotein combined with anti-CCP antibody to predict the activity of RA was 0.733, 0.745 and 0.819, respectively. 【Conclusion】Serum 14-3-3ηprotein and anti-CCP antibody have certain value in the diagnosis of RA and the evaluation of disease activity. If necessary, they can be combined for better diagnosis of RA to improve the diagnostic coincidence rate.
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Received: 24 June 2019
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2020, Vol. 37 
