Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages Board  |  Contact Us  |  中文

Forthcoming Articles    Current Issue    Archive    Advanced Search    Read Articles    Download Articles    Email Alert

Quick Search     Adv Search 2020 Vol. 37, No. 1 Published: 2020-01-30   4 Expression of IL-17 in the Serum of Patients with Recurrent Abortion and its Correlation with the Expression of Anticardiolipin Antibody YANG Li, HUANG Zhong-ying, MA Qian-hong, et al DOI: 10.3969/j.issn.1671-7171.2020.01.002 【Objective】To investigate the expression of interleukin-17 (IL-17) in patients with recurrent abortion (RSA) and its correlation with the expression of anticardiolipin antibody (ACA).【Methods】From December 2016 to March 2017, 46 RSA patients under 35 years old were selected for diagnosis and treatment in our reproductive clinic, including 20 ACA positive patients (ACA positive group) and 26 ACA negative patients (control group). The serum levels of IL-17 and ACA were detected by ELISA, and the correlation between them was analyzed. 【Results】The serum level of IL-17 in ACA positive group was (41.9 ± 5.5) pg / ml, which was significantly higher than that in the control group (32.1 ± 4.3) pg/mL, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that serum IL-17 level was positively correlated with ACA expression in RSA patients.【Conclusion】The increase of IL-17 in peripheral blood is one of the immune abnormalities in RSA patients with ACA positive, which may be involved in the immune mechanism of ACA induced abortion. 2020 Vol. 37 (1): 4-5 [Abstract] ( 87 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 6 Expression and Clinical Significance of IL-4, IL-6 and IL-8 in Serum of Patients with Chronic Obstructive Pulmonary Disease ZHENG Ying-ni, ZHOU Yan-hua DOI: 10.3969/j.issn.1671-7171.2020.01.003 【Objective】To investigate the expression levels of interleukin-4 (IL-4), interleukin-6 (IL-6) and interleukin-8 (IL-8) in the serum of patients with chronic obstructive pulmonary disease (COPD) and their clinical significance.【Methods】From February 2017 to may 2018, 40 COPD patients (COPD group) and 40 healthy adults who received physical examination in the same period were selected as the control group. The levels of serum IL-4, IL-6, IL-8, TNF-α, pulmonary function indexes (FVC, FVC1, MMEF and PEF) and blood gas indexes (pH, PaCO2,PaO2) were compared between the two groups.The correlation of serum IL -4, IL-6 and IL -8 with TNF-α, lung function and blood gas were analyzed. 【Results】The levels of IL-4, IL-6, IL-8 and TNF -αin the COPD group were higher than those in the control group (P<0.05); the levels of FVC, FVC1, MMEF and PEF in the COPD group were lower than those in the control group (P<0.05); the levels of pH and PaO2 in the COPD group were lower than those in the control group (P<0.05);the level of PaCO2 was higher than that of the control group (P<0.05); the levels of IL-4, IL-6 and IL-8 in the COPD group were positively correlated with the levels of TNF -αand PaCO2 , and FVC, FVC1, MMEF, PEF, pH and PaO2 were negatively correlated.【Conclusion】The serum levels of IL-4, IL-6 and IL-8 are higher in COPD patients, and are closely related to lung function and blood gas index. 2020 Vol. 37 (1): 6-8 [Abstract] ( 124 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 9 Application of Bilateral Abdominal Transverse Plane Block Combined with Single Lumbar Anesthesia in Cesarean Section and its Effect on Newborns WANG Zhan-peng, JIA Zheng DOI: 10.3969/j.issn.1671-7171.2020.01.004 【Objective】To investigate the application of bilateral abdominal transverse block combined with single spinal anesthesia in cesarean section and its effect on neonates.【Methods】A total of 66 maternal women who underwent cesarean delivery in our hospital were randomly divided into experimental group (33 cases) and control group (33 cases). The control group was given routine combined spinal epidural anesthesia and epidural analgesia. The experimental group was treated with bilateral transverse plane block combined with single spinal anesthesia. The effects of different anesthetic methods on cesarean section and neonatal were compared. 【Results】The VAS scores of the observation group were significantly lower than that of the control group at 3, 6, 9, 12 and 24 hours after cesarean section, and there was a significant difference between the two groups (P<0.05). The total complication rate of the observation group was 9.09% (3/33), which was significantly lower than that of the control group 33.33% (11/33), and there was significant difference between the two groups (P<0.05).There was no significant difference in blood gas indexes such as PH, partial pressure of oxygen, partial pressure of carbon dioxide and saturation of oxygen between the two groups after operation (P>0.05).【Conclusion】 The application of bilateral abdominal transverse plane block combined with single lumbar anesthesia in cesarean section has a significant effect, which can significantly reduce the dosage of narcotic drugs, reduce the postoperative pain of puerpera, and has a low rate of complications and adverse reactions. It is safe and reliable to use, which is worth popularizing. 2020 Vol. 37 (1): 9-11 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 12 Effects of Programmed Analgesia and Sedation Combined with Moderate Hyperventilation on Recovery Time and Cognitive Function in Patients with Severe Craniocerebral Injury ZOU Yan-qun DOI: 10.3969/j.issn.1671-7171.2020.01.005 【Objective】To explore the effect of programmed sedation and analgesia combined with moderate hyperventilation on recovery time and cognitive function of patients with severe craniocerebral injury after operation.【Methods】Ninty cases of severe craniocerebral injury collected in our hospital were selected as the research objects. All the selected patients were randomly divided into two groups, 45 cases in each group. The control group was treated with moderate hyperventilation, while the observation group was treated with programmed analgesia on the basis of the control group. The monitoring indexes of cerebral oxygen consumption(ICP、SjO2、CEO2、AVDO2), recovery time, sedative and analgesic effects and cognitive function were compared between the two groups. 【Results】ICP and SjO2 in the observation group were significantly higher than those in the control group (P<0.05), while CEO2 and AVDO2 in the observation group were significantly lower than those in the control group (P<0.05); the recovery time, extubation time and speaking time in the observation group were significantly shorter than those in the control group (P<0.05); SAS, VAS and RSS scores in the observation group were significantly lower than those in the control group (P<0.05); the cognitive efficiency of the observation group was significantly higher than that of the control group (P<0.05).【Conclusion】During the treatment of severe craniocerebral injury, programmed sedation and analgesia combined with moderate hyperventilation can fully relieve pain, reduce stress, reduce brain oxygen consumption and produce good brain protection. 2020 Vol. 37 (1): 12-14 [Abstract] ( 84 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 15 Effect of Risperidone Combined with Sertraline on sTNFRs and Neuroelectrophysiological Characteristics in Schizophrenic Patients with Negative Symptoms CHANG Xiao-juan, YANG Xiao-long,GAO Cheng-ge DOI: 10.3969/j.issn.1671-7171.2020.01.06 【Objective】To investigate the clinical effects of risperidone combined with sertraline in patients with schizophrenia-negative disease and its effects on soluble tumor necrosis factor receptor (sTNFRs) and neurophysiological characteristics.【Methods】The clinical data of 68 schizophrenic negative patients admitted to our hospital from May 2016 to November 2017 were analyzed retrospectively. They were divided into control group (risperidone) and observation group (risperidone combined with sertraline) according to different medication methods, 34 cases each. After 3 months of treatment, the negative symptoms, sTNFRs and electrophysiological characteristics of the two groups were compared.【Results】Three months after the treatment, the scores of emotional retardation, social disorder, personality isolation, frequent thinking and communication disorder in the observation group were lower than those in the control group, with statistical significance (P<0.05). The level of sTNFRs in the observation group was lower than that in the control group at 1, 2 and 3 months after treatment (P<0.05). After treatment, P300, N250 and ERN of the two groups were higher than before treatment, LPP amplitude was lower than before treatment; P300, N250 and ERN amplitude of the observation group were higher than that of the control group, LPP amplitude was lower than that of the control group, the difference was statistically significant (P<0.05).【Conclusion】Risperidone combined with sertraline in the treatment of negative schizophrenia can improve the symptoms, reduce the level of sTNFRs and improve the characteristics of neuroelectrophysiology, which is worth popularizing. 2020 Vol. 37 (1): 15-17 [Abstract] ( 93 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 18 Effects of Multidisciplinary SUPPORT Management Model Intervention on Patients with Spinal Cord Injury and Paraplegia QIU Tie-ying, WANG Wei-xing, TAN Xiao-ju,et al DOI: 10.3969/j.issn.1671-7171.2020.01.07 【Objective】To establish a multidisciplinary teamwork based on SUPPORT management model, comprehensively evaluate and intervene in patients with spinal cord injury and paraplegia, evaluate the effectiveness , quality of living and safety of this management model.【Methods】Starting from seven medical disciplines such as medical treatment, nursing, rehabilitation, nutrition, psychology, traditional Chinese medicine and hyperbaric oxygen, the support nursing mode was constructed; 58 patients with spinal cord injury and paraplegia surgery admitted to our hospital from January 2017 to December 2018 were given comprehensive intervention (observation group) by integrating resources and combining multiple specialties. 60 patients with spinal cord injury and paraplegia who received routine nursing in our hospital from January 2015 to December 2016 were collected as the control group. The patients in the two groups were compared in waiting time before operation, hospitalization time after operation, total hospitalization time, hospitalization cost and mortality 1 month, 3 months and 1 year after operation. The quality of life scores and patients' satisfaction were analyzed. 【Results】The time of waiting before operation, the time of hospitalization after operation, the total time of hospitalization and the cost of hospitalization in the observation group were significantly shorter than those in the control group, and the incidence of complications in the three months after operation was significantly lower than that in the control group, the difference was statistically significant (P<0.05). The difference was statistically significant (P<0.05). There was no significant difference in the two dimensions of hospital introduction and patients' overall attitude to the hospital (P> 0.05).【Conclusion】The construction of Support management mode can standardize the medical treatment and management of patients with spinal cord injury and paraplegia, scientifically carry out nursing and health guidance, so as to shorten the length of stay and improve patient satisfaction. 2020 Vol. 37 (1): 18-21 [Abstract] ( 82 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 22 Value of DCE-MRI Semi-quantification in Predicting the Sensitivity of Lung Cancer to Concurrent Chemoradiotherapy XIE Hong, CHEN Jian-ping, HE Jun-bin,et al DOI: 10.3969/j.issn.1671-7171.2020.01.08 【Objective】To investigate the value of DCE-MRI semi-quantification in predicting the sensitivity of patients with lung cancer to concurrent chemoradiotherapy and relationship with tumor regression rate.【Methods】 A total of 83 lung cancer patients who underwent concurrent chemoradiotherapy in our hospital were selected.DCE-MRI scan was used to analyze the relationship of semi-quantitative parameters with tumor regression rate and chemoradiotherapy sensitivity prediction. The imaging quality of DCE-MRI images were also observed in this study. 【Results】The DCE-MRI image quality showed that there were 61 cases (74.50%), 20 cases (24.09%), 2 cases (2.41%), and 0 cases in grade 3, 2, 1 and 0, irrespectively. The sensitivity, specificity and accuracy of concurrent chemoradiotherapy sensitivity prediction by DEE-MRI were 84.6%, 83.9% and 80.4%, irrespectively, based on the ROC curve analysis (Ve=0.20). After 1 month of treatment, there were 43 cases in the sensitive group and 40 cases in the insensitive group. The TTP value in the sensitive group was lower than that in the insensitive group, while the SERmax value in the sensitive group was significantly higher than that in the insensitive group ; the difference was statistically significant (P<0.05) . The values of PET, MSI and MSD in the two groups were not significantly different (P> 0.05). The tumor area decreased gradually after radiotherapy and chemotherapy; and the tumor area at 3 months after treatment was (7.23±3.01)cm2, which was significantly lower than that before radiotherapy and chemotherapy, while the tumor regression rate presented a gradually increasing trend , the difference was statistically significant (P<0.05). Ktrans, a semi-quantitative parameter of DCE-MRI, was positively correlated with tumor regression rate in lung cancer patients before treatment (r=0.421, P=0.014), and Ve was negatively correlated with tumor regression rate (r=-0.881,P=0.000). Patients who had higher value of Ktrans before treatment showed lower value of Ve, indicating more sensitive to concurrent chemoradiotherapy.【Conclusion】 DCE-MRI semi-quantitative parameter analysis shows a high value in predicting the sensitivity of radiotherapy and chemotherapy for lung cancer. The image quality is also good. Thus it can guide the selection of chemotherapy drugs to achieve the final curative effect, which is worthy of wide application. 2020 Vol. 37 (1): 22-25 [Abstract] ( 120 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 26 Value of Transvaginal Doppler Ultrasound and Hysteroscopy in the Diagnosis of Endometrial Lesions YANG Xiu-mei, BI Cui, SHAO Ying-hua, et al DOI: 10.3969/j.issn.1671-7171.2020.01.009 【Objective】To analyze the value of transvaginal doppler ultrasound and hysteroscopy in the diagnosis of endometrial lesions.【Methods】Ninety-four patients with endometrial lesions treated in our hospital from August 2015 to January 2018 were retrospectively analyzed. The results of transvaginal doppler ultrasound and hysteroscopy were analyzed, and the pathological diagnosis were used as the criterion for judgement. 【Results】The pathological diagnosis results of 94 cases of endometrial diseases were 28 cases of endometrial hyperplasia, 16 cases of endometrial polyps, 12 cases of submucous myoma, 8 cases of endometrial cancer, 15 cases of endometritis, 6 cases of endometriosis, 9 cases of endometrial atrophy. According to the results of pathological diagnosis, there were 22 cases of endometrial hyperplasia (4 cases missed diagnosis, 2 cases misdiagnosed as endometrial polyps), 13 cases of endometrial polyps (1 case missed diagnosis, 2 cases misdiagnosed as endometrial hyperplasia), 9 cases of submucous myoma (3 cases missed diagnosis), 11 cases of endometritis (4 cases missed diagnosis, 1 case misdiagnosed as endometrial hyperplasia), 4 cases of endometriosis (2 cases misdiagnosed as endometrial hyperplasia), 9 cases of endometrial atrophy (no missed diagnosis and misdiagnosis) According to the pathological diagnosis results, hysteroscopy diagnosed 26 cases of endometrial hyperplasia (2 cases misdiagnosed as endometriosis), 15 cases of endometrial polyps (1 case missed diagnosis), 11 cases of submucous myoma (1 case misdiagnosed as submucous cyst), 6 cases of endometrial carcinoma (1 case missed diagnosis, 1 case misdiagnosed as submucous myoma), 14 cases of endometritis (1 case misdiagnosed as endometrial hyperplasia), 5 cases of endometriosis (1 case missed diagnosis), 9 cases of endometrial atrophy (no missed diagnosis and error) Diagnosis. The total accuracy rate of hysteroscopy was 91.49% (86 / 94), which was significantly higher than 76.60% (72 / 94) of vaginal Doppler ultrasound, and the accuracy rate of hysteroscopy for various diseases was significantly higher than that of vaginal Doppler ultrasound, with a statistically significant difference (P<0.05).【Conclusion】Vaginal Doppler ultrasound and hysteroscopy have certain value in the classification of endometrial lesions, and the diagnosis rate of hysteroscopy is higher. However, transvaginal Doppler ultrasound and hysteroscopy have their own advantages. When they are used in the diagnosis and treatment of clinical diseases, they can choose the diagnosis mode according to the actual situation of patients and carry out targeted treatment, so as to improve the accuracy of disease diagnosis and reduce unnecessary medical costs. 2020 Vol. 37 (1): 26-28 [Abstract] ( 104 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 29 Relationship between Levels of CD3+CD4+ T cells and CD3+CD8+ T cells and the Prognosis of Patients with Advanced Non-small Cell Lung Cancer ZHAN Feng, LIU Qian, HE Guang-zhao,et al DOI: 10.3969/j.issn.1671-7171.2020.01.010 【Objective】To study the relationship between the levels of CD3+CD4+T cells and CD3+CD8+T cells and the prognosis of patients with advanced non-small cell lung cancer(NSCLC).【Methods】 One hundred and eighty patients with advanced NSCLC cancer were treated in our hospital. All patients received PG chemotherapy (Pemetrexed + Nedaplatin) for 2 cycles.Peripheral venous blood samples of patients after chemotherapy were collected, and the levels of T lymphocyte subsets (CD3+CD4+, CD3+CD8+) were determined . Multivariate logistic regression analysis was used to analyze the independent influencing factors of patients' short-term prognosis and to observe the relationship between the levels of CD3+CD4+, CD3+CD8+ and patients' short-term prognosis. 【Results】 After two chemotherapy cycles of 180 patients, 43 cases (23.89%) of PR and 116 cases (64.44%) of SD were found and were included in the disease control group, while 21 cases (11.67%) of PD were included in the disease uncontrolled group; the proportion of KPS score ≥ 80, tumor diameter ≥ 5cm, low differentiation, TNM stage IV, platelet count ≥ 300×109/L in the disease control group were significantly lower than those in the disease uncontrol group (P<0.05); the levels of CD3+CD4+, CD3+CD8+ were significantly higher than those of the disease uncontrol group (P<0.05). Multivariate logistic regression analysis revealed that KPS score, tumor diameter, degree of differentiation, TNM stage and extra-platelet count were independent influencing factors for the recent prognosis of patients with advanced NSCLC (P<0.05), whereas CD3+CD4+, CD3+CD8+ levels were not independent influencing factors for the recent prognosis of patients (P>0.05).【Conclusion】The recent efficacy of chemotherapy for advanced NSCLC cancer is not significantly correlated with CD3+CD4+, CD3+CD8+ levels, suggesting that detection of peripheral blood t lymphocyte subsets could not serve as a basis for judging the efficacy of chemotherapy. 2020 Vol. 37 (1): 29-32 [Abstract] ( 127 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 33 Influence of Humanistic Care Ward on Medication Compliance, Social Function and Satisfaction of Inpatients with Schizophrenia DAI Jin-jun, LUO Yao-yue, YU Jian-ying, et al DOI: 10.3969/j.issn.1671-7171.2020.01.011 【Objective】To analyze the influence of humanistic care ward on medication compliance, social function and patient satisfaction of inpatients with schizophrenia.【Methods】A total of 78 schizophrenics admitted to the general psychiatric ward of our hospital were selected as the control group, and 85 schizophrenics admitted after the establishment of humanistic care ward were taken as the observation group. The control group was given routine nursing measures, and the observation group was given humanistic care ward nursing on the basis of the control group. The medication compliance, personal and social function scale (PSP), concise psychiatric scale (BPRS), and patient satisfaction at discharge at admission of 2 weeks,4 weeks, and 6 weeks of admission were compared in the two groups. 【Results】The PSP scores were higher in the two groups at admission for 2 weeks,4 weeks and 6 weeks, the BPRS score was lower than that at admission, and the PSP score in the observation group at 4 weeks and 6 weeks was higher than that in the control group, and the BPRS score was lower than that of the control group,the difference was statistically significant (P<0.05).The total scores of nursing service, mental health education, humanistic care and satisfaction in the observation group were significantly higher than those in the control group (P<0.05) 【Conclusion】Humanistic care ward nursing can improve the clinical symptoms of schizophrenics, improve the compliance of patients with medication, social function and nursing satisfaction, which is worthy of clinical application. 2020 Vol. 37 (1): 33-35 [Abstract] ( 91 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 36 Effect of Tamoxifen Combined with Gestrinone on the Prevention of Postoperative Recurrence of Endometriosis YAO Jing, SUN Jing, LIU Su-qin DOI: 10.3969/j.issn.1671-7171.2020.01.012 【Objective】To explore the clinical effect of tamoxifen combined with gestrinone in the prevention of postoperative recurrence of endometriosis.【Methods】From January 2016 to January 2017, 86 patients with endometriosis who were treated in Taikang Xianlin Gulou Hospital and Huaiyin Hospital of Huai'an City, Jiangsu Province were randomly divided into the observation group and the control group according to the random number table method. The control group was treated with gestrinone, and the observation group was treated with tamoxifen on the basis of the control group. The clinical effect, immune function, estrogen (E2) and follicle stimulating hormone (FSH) were compared between the two groups. 【Results】The total effective rate of the observation group was significantly higher than that of the control group (97.7% vs 83.7%), and the recurrence rate was lower than that of the control group (2.32% vs 16.28%). The difference was statistically significant [χ2 (effective)=5.109,P=0.024;χ2(recurrence) = 4.962, P=0.026]. Before treatment, there was no significant difference in immune function indexes and hormone levels between the two groups (P> 0.05); after treatment, the levels of CD4+ CD8+ CD4+/CD8+ in the two groups were increased, and the increase was more obvious in the observation group (P<0.05); the levels of E2 and FSH were decreased, and the decrease was more obvious in the observation group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 2.3% (1/43), which was significantly lower than that in the control group 20.9% (9/43), and the difference was statistically significant (P<0.05).【Conclusion】Tamoxifen combined with gestrinone can prevent the recurrence of endometriosis after operation. It has a significant effect, improves the immune function and hormone level of patients, and has a high safety. It is worthy of clinical application. 2020 Vol. 37 (1): 36-38 [Abstract] ( 85 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 39 Expression and Significance of GPR30 in Chorionic Villi of Early Damaged Embryos LIU Li-wen, YANG Chao-lan, LING Yan-zhi DOI: 10.3969/j.issn.1671-7171.2020.01.013 【Objective】To investigate the expression of G protein-couple receptor (GPR30) in chorionic villi of early pregnancy embryo damage and its correlation with estrogen receptor (ER) and progesterone receptor (PR).【Methods】A total of 100 cases of chorionic villous tissues from March 2017 to March 2018 were selected from the First Hospital of Changsha. There were 50 cases with embryo damage for abortion (the observation group) and 50 cases of normal early pregnancy requiring pregnancy termination (the control group). The expression level of GPR30,ER and PR in villus tissue was detected by immunohistochemical staining and the average optical density value of staining was measured. 【Results】The average optical density values of GPR30,ER and PR staining in the villus tissue of normal early pregnancy group were 0.37±0.07,0.34±0.07 and 0.30±0.05,respectively.The average optical density values of GPR30,ER and PR staining in the embryo damage group were 0.30±0.06, 0.28±0.06 and 0.30±0.04,respectively.The expression levels of GPR30,ER and PR in villus tissue of the normal early pregnancy group were higher than those in the embryo damage group; and the differences were statistically significant (P<0.05). There was a positive correlation between ER and PR expression in the villous tissue of pregnant women with embryo damage for abortion (r=0.486, P=0.000); however, there was no significant correlation of GPR30 with ER and PR expression (r=-0.120,P=0.252; r=-0.027,P=0.794).【Conclusion】The levels of GPR30,ER and PR expression in early pregnancy chorionic villus tissue of abortion caused by embryo damage are significantly lower than those in normal chorionic villi of early pregnancy. There is no significant correlation of GPR30 with ER and PR in the villous tissue of the two groups of pregnant women. The expression of ER shows a positive correlation with PR expression in early pregnancy villus tissue, indicating that the two hormone receptors interact with each other in the process of maintaining pregnancy. 2020 Vol. 37 (1): 39-41 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 42 Effect of Xingnaojing Injection Combined with Alteplase Intravenous Thrombolytic Therapy on Neurological Function in Patients with Acute Cerebral Infarction LIU Cheng DOI: 10.3969/j.issn.1671-7171.2020.01.014 【Objective】To explore the treatment effect of Xingnaojing injection combined with intravenous thrombolysis of atteplase on the neurological function of patients with acute cerebral infarction.【Methods】A total of 90 patients with acute cerebral infarction who admitted to our hospital were randomly divided into the observation group and the control group, with 45 cases in each group. Patients in the control group were only treated with alteplase thrombolytic therapy. While patients in the observation group were treated with Xingnaojing injection combined with alteplase intravenous thrombolytic therapy. Scores of NIHSS, concise Fugl-Meyer scale and ESS, Barthel index, efficacy and adverse events were compared between the two groups before treatment (T1), 1 week after treatment(T2) and 1 month after treatment (T3), respectively.【Results】There were no differences in the scores between the two groups at T1 (P＞0.05). The scores of NIHSS at T2 and T3 of both groups were lower than those of the previous time point (P＜0.05), while the NIHSS scores in the observation group were lower than those in the control group (P＜0.05).The scores of the concise fugl-meyer scale, Barthel index and ESS of the two groups at T2 and T3 were higher than those of the previous period (P＜0.05); and the above scores in the observation group were higher than those in the control group (P＜0.05).The total effective rate of the observation group was 95.56% (43/45), which was higher than that of the control group 80.00% (36/45,P＜0.05).The incidence of adverse reactions in the observation group was 8.89% (4/45), which was significantly lower than that in the control group 26.67% (12/45,P＜0.05).【Conclusion】The treatment of Xingnaojing injection combined with alteplase intravenous thrombolysis has better therapeutic effects on patients with acute cerebral infarction with less adverse reactions. It greatly improves the neurological function, rehabilitation, self-care ability and exercise capacity of patients, which is worthy of clinical application. 2020 Vol. 37 (1): 42-44 [Abstract] ( 82 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 45 Expression of CircRNA_0006633 in Liver Cancer Tissues and Its Effect on Cell Proliferation LUO Ze-bin, CHEN Zhi-an,CHEN Long-lin,et al DOI: 10.3969/j.issn.1671-7171.2020.01.015 【Objective】To detect the expression of circRNA_0006633 in liver cancer tissues and explore its biological regulation on cell proliferation, apoptosis and cell cycle.【Methods】Real-time quantitative polymerase chain reaction (RT-qPCR) was used to analyzed the expression level of circRNA_0006633 in liver cancer tissues and adjacent normal tissues, while the relationship between circRNA_0006633's expression and clinicopathological parameters was further determined. Then biological effects of circRNA_0006633 overexpression by lentivirus-mediated-plasmids (circ_0006633-pcDNA 3.1 plasmids)on cell proliferation, apoptosis, and cycle were investigated by RT-qPCR, western blot, CCK8 and flow cytometry.【Results】Compared to the paired adjacent normal tissues, the expression level of circRNA_0006633 in liver cancer tissues was lower. Furthermore, the low expression circRNA_0006633 was negatively correlated with survival outcome. Upregulation of circRNA_0006633 effectively reduced cell proliferation, increased apoptosis and arrested cells at G2/M phages, while the epithelial-mesenchymal transition (EMT)-related proteins were regulated as well.【Conclusion】Expression of circRNA_0006633 is lower in liver cancer tissues. circRNA_0006633 can inhibit the process of epithelial-mesenchymal transition pathway activation and reduce the proliferation of liver cancer cells, which provides new ideas for the treatment of liver cancer. 2020 Vol. 37 (1): 45-49 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 50 Clinical Characteristics of Patients with Chronic Kidney Disease Complicated with Metabolic Syndrome QIAN Li-ya, ZHAO Yu, XU Jie DOI: 10.3969/j.issn.1671-7171.2020.01.016 【Objective】To investigate the clinical characteristics of patients with chronic kidney disease complicated with metabolic syndrome (MS).【Methods】A total of 164 patients with chronic kidney disease were divided into two groups: MS group (group A) and non-MS group (group B). Patients were furthermore put in three groups (Ⅰ,Ⅱ and Ⅲ) according to the amount of urine protein. Fasting blood glucose (FBG), triacylglycerol (TG), serum creatinine (SCr), blood uric acid (UA), and high-density lipoprotein (HDL-C), estimate glomerular filtration rate (eGFR), body mass index (BMI), urine protein, systolic and diastolic blood pressure were recorded. The incidence of MS in patients with different urinary protein content was observed and compared. Multivariate regression analysis was performed on the factors that may affect the urine protein content. 【Results】Among 164 patients, 62 patients in group A had MS, accounting for 37.80%; 102 patients in group B had no MS, accounting for 62.20%. The levels of systolic blood pressure , diastolic blood pressure, FBG,TG,SCr,UA,BMI and urine protein in group A were higher than those in group B, while levels of HDL-C and eGFR in group A were lower than those in group B (P<0.05). With increasing urinary protein content, the eGFR of patients in group Ⅰ,Ⅱ and Ⅲ gradually decreased. The eGFR of group Ⅰ was significantly higher than that of group Ⅱ and group Ⅲ (P<0.05). Systolic blood pressure , diastolic blood pressure, FBG , TG、HDL-C、SCr、BMI and MS incidence rate in group Ⅰ were lower than those in group Ⅱ and Ⅲ (P<0.05). Increased waist-to-hip ratio was the only independent risk factor for the occurrence of moderate proteinuria, while mildly elevated blood glucose, increased TG/HDL-C ratio, advanced age and increased waist-to-hip ratio were independent risk factors for the development of massive proteinuria.【Conclusion】Patients with chronic kidney disease patients have a high rate of metabolic syndrome. Fasting blood glucose, increased waist-to-hip ratio and dyslipidemia are independent risk factors for the development of massive proteinuria in patients with chronic kidney disease. Therefore, early intervention of MS can effectively delay the progression of chronic kidney disease. 2020 Vol. 37 (1): 50-52 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 53 Effects of 3D-designed Orthopedic Insoles and Medical Exercise on Pain and Foot Function in Patients with Plantar Fasciitis GAN Dao-fu, JU Yu-xing, ZHANG Huan,et al DOI: 10.3969/j.issn.1671-7171.2020.01.017 【Objective】 To investigate the effects of 3D-designed orthopedic insoles and medical exercise on pain and foot function in patients with plantar fasciitis.【Methods】A total of 80 patients with plantar fasciitis in our hospital from September 2017 to September 2018 were selected as the research object. The patients were divided into the observation group and the control group by random number table method, with 40 cases in each group. Patients in the observation group received 3D-designed orthopedic insoles combined with medical exercise, while patients in the control group only received medical exercise intervention. The recovery of foot function before and after intervention was compared between the two groups. The difference of foot function score (AOFAS), foot pain degree and movement disorder degree between the two groups before and after intervention was compared. The plantar fascia thickness and the longest walking time between the two groups before and after intervention was recorded as well. 【Results】The AOFAS score of the observation group after treatment was significantly higher than that of before treatment and the control group (P<0.05).The excellent and good rate of the observation group was 73.00%, which was significantly higher than that of the control group 35.00% (P<0.05).The scores of foot pain and movement disorder in the observation group after intervention were significantly lower than those in the pre-intervention observation group and the post-intervention control group (P<0.05).The thickness of plantar fascia in the observation group after intervention was significantly lower than that in the pre-intervention observation group and the post-intervention control group (P<0.05).The longest walking time in the observation group after the intervention was significantly lower than that in the pre-intervention observation group and the post-intervention control group (P<0.05).【Conclusion】The 3D-designed Orthopedic insole combined with medical exercise can effectively relieve foot pain and movement disorders of patients with plantar fasciitis, which is worthy of clinical application. 2020 Vol. 37 (1): 53-55 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 56 Effect of Selective Axillary Lymph Node Preservation on Early Postoperative Lymphedema in Patients with Breast Cancer LIAO Yu-ling, HUANG Qing-wei, DAI Li-na DOI: 10.3969/j.issn.1671-7171.2020.01.018 【Objective】To discuss the effect of selective axillary lymph node retention on early postoperative lymph node edema in breast cancer patients.【Methods】From May 2013 to February 2016, 136 patients with early breast cancer were divided into two groups: arm group (n=70, observation group) and ALND group (n=66, control group). All patients were followed up for 6 months. The occurrence of lymphedema and the effect of prevention were compared between the two groups. One week (T0), one month (T1) and six months (T2) after operation, MP, C-15 and the SUM of the two groups were compared. Lbcq and FACT-B were used to evaluate the severity and quality of life of the patients at T0~T2 baseline. 【Results】The increase percentage of MP, C-15 and SUM in the affected side decreased gradually (P<0.05). The increase percentage of MP, C-15 and SUM in the observed group was lower than that in the control group at T0~T2 (P<0.05). The LBCQ score of the two groups decreased gradually (P<0.05), and the FACT-B score increased gradually (P<0.05). The LBCQ score of the observation group was lower than that of the control group at T0~T2 (P<0.05), and the FACT-B score was higher than that of the control group (P<0.05). The incidence of upper extremity edema was 7.14% (5 / 70) in the observation group and 24.24% (16 / 66) in the control group 6 months after operation, the difference was statistically significant (χ2 = 4.204,P=0.04<0.05). The excellent and good rate of edema prevention in the observation group was 88.57% (62/70) higher than that in the control group 69.70% (46 / 66). The difference was statistically significant (χ2=7.402,P=0.007<0.05).【Conclusion】Selective preservation of axillary lymph nodes can prevent and reduce the incidence and degree of postoperative lymphedema in the upper extremity of patients with early breast cancer, and improve the quality of life after operation. 2020 Vol. 37 (1): 56-59 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 60 Clinical Study of 3D Printing Guide Plate Technique in Pedicle Screw Placement of Upper Cervical Vertebrae ZHANG Yuan-guang, LV Guo-hua DOI: 10.3969/j.issn.1671-7171.2020.01.019 【Objective】To evaluate the clinical value of navigation templates by 3D printing technique in pedicle screw placement of upper cervical vertebra.【Methods】 The clinical data of 40 patients with atlantoaxial fracture and dislocation required for posterior pedicle screw placement in spinal surgery in the Second Hospital of Xiangya, Central South University from october 2015 to march 2018 were retrospectively analyzed. According to the method of nail placement, it was divided into 3D printed guide plate assisted nail placement group (test group) and traditional X-ray fluoroscopy transpedicular nail placement group (control group). the preoperative and postoperative pain visual analogue scores (VAS) and the cervical vertebrae japan orthopedic association (JOA) scores, the average time of single screw placement, intraoperative bleeding, fluoroscopy times, and the accuracy of comparing nails were compared between the two groups. 【Results】The clinical function of the two groups of patients after operation (neck and shoulder VAS score and cervical JOA score) was significantly improved compared with that before operation (P<0.05), but there was no significant difference in sex, age, preoperative and postoperative VAS and JOA scores between the two groups (P>0.05). The accuracy of the two groups, the average time of single screw placement, the number of fluoroscopy, and the difference of intraoperative bleeding were statistically significant (P<0.05). 【Conclusion】 For patients with atlantoaxial fracture and dislocation,3D printing guide plate technology not only has higher nail placement accuracy, but also has the advantages of short average time of single screw placement, less fluoroscopy times and less bleeding during operation, and has good clinical application value. 2020 Vol. 37 (1): 60-63 [Abstract] ( 86 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 64 Level Changes and Clinical Significance of Plasma ADAMTS13 and VWF in Patients with Acute and Chronic Cerebrovascular Disease LIU Mei-xia, ZHOU Long, ZHU Zu-xin,et al DOI: 10.3969/j.issn.1671-7171.2020.01.020 【Objective】To investigate the level changes and clinical significance of plasma ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif) and vWF (von Willebrand factor) in patients with acute ischemic stroke (AIS) and chronic cerebrovascular disease (CCVD).【Methods】A retrospective analysis of the clinical data of 86 patients with acute ischemic stroke (the AIS group), 94 cases of CCVD (the CCVD group) and 89 cases of healthy physical examination volunteers (the CON group) that collected in our hospital from April 2016 to April 2017 were conducted. the levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were analyzed by automatic biochemical analyzer; enzyme linked immunosorbent assay (ELISA) was used to detect plasma ADAMTS13 antigen and vWF antigen levels, and vWF:ADAMTS13 ratio was calculated. The correlation between ADAMTS13 antigen and vWF antigen was analyzed; and the diagnostic value in disease were explored. 【Results】The levels of TC, TG and LDL-C in the AIS group and the CCVD group were significantly higher than those in the CON group, and HDL-C was significantly lower than that in the CON group (P<0.05). There was no significant difference of above indicators between the AIS group and the CCVD (P>0.05). The vWF antigen and vWF:ADAMTS13 in the AIS group and the CCVD group were significantly higher than those in the CON group; the vWF antigen and vWF:ADAMTS13 in the AIS group were higher than those in the CCVD group (P<0.05). The ADAMTS13 antigen in the AIS group and the CCVD group was significantly lower than that in the CON group; the ADAMTS13 antigen in the AIS group was lower than that in the CCVD group (P<0.05). In the AIS group and the CCVD group, vWF antigen was negatively correlated with ADAMTS13 antigen (P<0.05). Furthermore, vWF antigen was positively correlated with TC, TG and LDL-C but negatively correlated with HDL-C; ADAMTS13 antigen was negatively correlated with TC, TG and LDL-C, but positively correlated with HDL-C (P<0.05). Finally, ROC analysis in the AIS group and the CCVD group showed that the diagnostic value of vWF:ADAMTS1 was higher than that of vWF antigen and ADAMTS13 antigen alone.【Conclusion】ADAMTS13 and vWF participate in the occurrences and developments of AIS and CCVD diseases, and they are closely related to dyslipidemia. VWF:ADAMTS13 can be used as an effective indicator for clinical diagnosis. 2020 Vol. 37 (1): 64-67 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 68 Treatment of Lower Extremity Arterial Thrombus with Arterial Catheterization and Thrombolysis Combined with Angiojet Thrombus Extraction System ZENG Guang, HUANG Yi, HUANG Rong,et al DOI: 10.3969/j.issn.1671-7171.2020.01.021 【Objective】To explore the effect of CDT combined with Angiojet thrombus extraction system on lower extremity arterial thrombosis, ankle brachial index (ABI) and amputation rate.【Methods】From January 2018 to June 2019, 60 patients with lower extremity arterial thrombosis were selected and divided into observation group and control group according to the random number table method, 30 in each group. The patients in the control group were treated with CDT, and the patients in the observation group were treated with Angiojet thrombus aspiration system combined with CDT. The therapeutic effect, perioperative index, ABI, amputation rate, urokinase usage, catheter retention time and SF-36 score of the two groups were compared. 【Results】The clinical excellent and good rate of the observation group was 83.33% (25 / 30) higher than that of the control group (60.00% (18 / 30), the difference was statistically significant (χ2 = 4.023, P<0.05). The SBP, PaO2 and SpO2 levels of the two groups were higher than those before treatment, and the SBP level of the observation group was lower than that of the control group, and the PaO2 and SpO2 levels of the observation group were higher than that of the control group, the difference was statistically significant (P<0.05). After treatment, the ABI of the two groups increased significantly, and the ABI of the observation group was significantly higher than that of the control group, the amputation rate was significantly lower than that of the control group, and the use of urokinase and catheter retention time of the observation group were significantly lower than that of the control group (P<0.05). The scores of physiological function, social function, physiological function, vitality, emotional function, mental health, physical pain and general health in the observation group were significantly higher than those in the control group (P<0.05).【Conclusion】CDT combined with Angiojet thrombus extraction system can increase the ABI index and reduce the amputation rate in patients with lower extremity arterial thrombus, which is worth clinical application. 2020 Vol. 37 (1): 68-70 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 71 Changes in Ventricular Function and Systolic Synchrony after Closure of Ventricular Septal Defect TANG Zhong-cai DOI: 10.3969/j.issn.1671-7171.2020.01.022 【Objective】To evaluate the changes of ventricular function and systolic synchrony after transcatheter closure of ventricular septal defect (VSD) by transesophageal echocardiography.【Methods】 The clinical data of 85 ventricular septal defect patients who underwent transcatheter closure in our hospital from June 2016 to February 2018 were retrospectively analyzed. Transesophageal echocardiography was performed at 1 weeks before surgery and 3, 6 months after surgery respectively. Left ventricular end systolic volume (ESV), left ventricular end diastolic volume (EDV), left ventricular ejection fraction (LVEF), standardized value of peak ejection rate (PER/EDV), standardized value of peak filling rate (PFR/EDV) and systolic synchrony parameters: normalized value of the time difference between the 16 ventricular segments of the left ventricle reaching the end-systolic minimum volume (Tmsvl6-Dif / R-R%) and standard deviation normalized value (Tmsvl6-SD / R-R%) were obtained. 【Results】Compared to the value of 1 week before surgery, the ESV, EDV, LVEF, Tmsv 16-SD/R-R% and Tmsv 16-Dif/R-R% decreased significantly at 3 months after surgery (P<0.05). At 6 months after surgery, ESV, EDV and LVEF decreased further compared to 3 months after surgery (P<0.05). There were no significant differences in Tmsv 16-SD/R-R% and Tmsv 16-Dif/R-R% between 3 months and 6 months after surgery (P>0.05). Compared to pre-operation condition, PER / EDV decreased significantly at 6 months after surgery (P<0.05), while PFR / EDV did not have significant decrease (P>0.05).【Conclusion】Transesophageal echocardiography showed that ventricular function and systolic synchrony were improved significantly after transcatheter closure of ventricular septal defect. 2020 Vol. 37 (1): 71-73 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 74 Clinical Value of Magnetic Resonance Cholangiopancreatography and Intraoperative Cholangiography before Laparoscopic Cholecystectomy JI Gang, HUANG Wen-lei, CAO Hua-xiang DOI: 10.3969/j.issn.1671-7171.2020.01.023 【Objective】To explore the clinical value of magnetic resonance cholangiopancreatography (MRCP) and intraoperative cholangiography (IOC) before laparoscopic cholecystectomy (LC).【Methods】A total of 70 patients with gallstones who underwent LC in our hospital from April 2015 to April 2017 were selected as the research objects. They were randomly divided into the observation group and the control group, with 35 cases in each group.LC was performed in both groups. Patients in the observation group received MRCP before operation, while patients in the control group received IOC during operation. After operation, the results of MRCP and IOC were compared between the two groups, including Mirizzi syndrome, right parahepatic duct, bile duct obliquely crossing the common hepatic duct and abnormal convergence of biliopancreatic duct. The perioperative clinical indexes including operation time, hospitalization time, biliary duct injury and conversion to laparotomy of the two groups were compared. The occurrence of postoperative complications in the two groups was recorded.【Results】 There were no significant differences in terms of Mirizzi syndrome, right parahepatic duct, bile duct obliquely crossing the common hepatic duct and abnormal convergence of biliopancreatic duct between the observation group and the control group (P>0.05).The operation time and hospitalization time of the observation group were shorter than those of the control group (P<0.05). Compared to the control group, the proportion of biliary tract injury and conversion to laparotomy in the observation group was not significantly different from the control group (P>0.05). The incidence of postoperative complications was 11.43% (4/35) in the observation group and 25.71% (9/35) in the control group, however, the difference was not statistically significant (χ2=2.362, P>0.05).【Conclusion】MRCP can diagnose patients accurately and noninvasively before operation, reduce the trauma of patients, shorten the time of operation and hospitalization, and avoid complications. It is worthy of clinical promotion. 2020 Vol. 37 (1): 74-76 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 77 Study on Analgesic Effect of Dexmedetomidine in Patients with Rotator Cuff Repair HE Qi, QIN Yan, WU Wen-zhi DOI: 10.3969/j.issn.1671-7171.2020.01.024 【Objective】To explore the analgesic effect of dexmedetomidine(Dex)in patients with rotator cuff repair surgery.【Methods】A total of 41 cases of shoulder arthroscopic rotator cuff repair in our hospital were selected. According to the random number table method, the patients were randomly divided into the observation group (21 cases) and the control group (20 cases). All patients were given intravenous general anesthesia. While the observation group also received Dex and the control group received an equal amount of physiological saline. The general data, sedation and analgesia scores at 2, 4, 8, 12 and 24 hours after operation were compared between the two groups. The incidence of adverse reactions in the two groups was compared as well【Results】The visual analogue scale (VAS) scores of the observation group were lower than those of the control group at 2h, 4h and 8h after operation (P<0.05). The sedation Ramsay scores at 2h and 4h after surgery were higher than those of the control group. The differences were statistically significant(P<0.05). The overall incidence of adverse reactions in the observation group was 23.81% (5/21),which was no statistical significance (P>0.05) compared to 20% (4/20) in the control group.【Conclusion】Dexmedetomidine can effectively prolong the first postoperative analgesia time in patients with rotator cuff repair surgery and reduce the pain of patients. 2020 Vol. 37 (1): 77-78 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 79 Effect of Lower Respiratory Tract Infection on β-catenin Signaling Pathway in Patients with Chronic Obstructive Pulmonary Disease BAO Zhi-wei, ZENG Shao-lin DOI: 10.3969/j.issn.1671-7171.2020.01.025 【Objective】To investigate the effect of lower respiratory tract infection on the relative expression of beta-catenin in patients with chronic obstructive pulmonary disease (COPD).【Methods】A total of 94 patients with chronic obstructive pulmonary disease diagnosed and treated in the Department of Respiratory Medicine of the People's Hospital of Wuhan University were selected and divided into COPDⅠ(n=29) group, COPDⅡ(n=35) group, and COPDⅢ(n=30) group according to the pulmonary function classification of patients. According to whether the patients had lower respiratory tract infection, they were further divided into the infected group (n=56) and uninfected (n=38) group. The influence of lung function and respiratory tract infection on the relative expression of β-catenin was detected and analyzed. The relative expression of β-catenin in predicting the value of lower respiratory tract infection in patients with COPD was analyzed by ROC curve. 【Results】The FVC (forced vital capacity), FEV1 (forced expiratory volume in the first second), FEV1/FVC and β-catenin expression were statistically significant in the lung function of the patients with different COPD condition (P<0.05). With the aggravation of the COPD patients, the FVC, FEV1, FEV1/FVC decreased significantly (P<0.05), and the relative expression of β-catenin increased significantly (P<0.05). The FVC, FEV1 and FEV1/FVC in the infected group were significantly lower than those in the uninfected group (P<0.05), while the relative expression of β-catenin in the infected group was significantly higher than that in the uninfected group (P<0.05). The relative expression of β-catenin was negatively correlated with FVC, FEV1 and FEV1/FVC (P<0.05). The ROC curve was used to analyze the predictive value of the relative expression of beta -catenin in respiratory tract infection in patients with chronic obstructive pulmonary disease (COPD). The area under the ROC curve of the relative expression of β-catenin for the diagnosis of lower respiratory tract infection in COPD patients was 0.875.【Conclusion】There is a significant correlation between the abnormal expression of Wnt/beta-catenin signaling pathway and pulmonary function in COPD patients. The change of relative expression of beta-catenin in COPD patients caused by lower respiratory tract infection suggest it has a certain diagnostic value for COPD patients. 2020 Vol. 37 (1): 79-82 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 83 Effect of Scalp Nerve Block on Stress Status and Cerebral Blood Flow in Patients with Hypertensive Intracerebral Hemorrhage during Stereotactic Intracranial Hematoma Removal ZHAO Guang-ping, SHI Jiong, CHENG Jing-jing,et al DOI: 10.3969/j.issn.1671-7171.2020.01.026 【Objective】To compare the effect of stereotactic intracranial hematoma removal with SNB anesthesia and local infiltration anesthesia on stress state and cerebral blood flow index in patients with hypertensive intracerebral hemorrhage.【Methods】The clinical data of 102 patients with hypertensive intracerebral hemorrhage who underwent stereotactic evacuation of intracranial hematoma from June 2017 to December 2018 were analyzed retrospectively. According to the different anesthesia methods, they were divided into block anesthesia group and infiltration anesthesia group, 51 cases each; the changes of serum fasting blood glucose (FPG), cortisol (Cor) level and arterial partial pressure of oxygen (PaO2), arterial partial pressure of oxygen (PaCO2), arterial oxygen saturation (SaO2) and mean arterial pressure (MAP) were compared between the two groups when entering the chamber (T0), at scalp incision (T1), at craniotomy (T2) and at suture (T3). 【Results】 There was no significant difference between PaO2, PaCO2, SaO2 and MAP at T0, T1, T2, T3 in the block anesthesia group (P>0.05). In the invasive anesthesia group, PaO2 was lower than T0 at T1, T2, T3, and PaCO2, MAP was higher than T0, and the difference was statistically significant (P<0.05); the PaO2 was lower in the invasive anesthesia group T1, T2, T3 than in the block anesthesia group, and PaCO2, MAP was higher than in the block anesthesia group, the difference was statistically significant (P<0.05). There was no significant difference in serum FPG and Cor levels in the block anesthesia group T0, T1, T2, T3(P>0.05). The average water of FPG and Cor in the invasive anesthesia group T1, T2, T3 was higher than that of T0, and all were higher than those in the simultaneous point block anesthesia group, the difference was statistically significant (P<0.05).【Conclusion】 Stereotactic evacuation of intracranial hematoma with scalp nerve block anesthesia for patients with hypertensive cerebral hemorrhageare has little effect on cerebral blood flow and light stress response with much more safety, and is better than local infiltration anesthesia. 2020 Vol. 37 (1): 83-85 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 86 Prognostic Value of Serum NT-proBNP and Cys-C Levels in Elderly Patients with Chronic Heart Failure Complicated with Acute Renal Injury LIU Ying-hua, GAO Xiao-li, ZHANG Xiao-kun,et al DOI: 10.3969/j.issn.1671-7171.2020.01.027 【Objective】To analyze the prognostic value of serum NT proBNP and Cys-C levels in elderly patients with chronic heart failure (CHF) combimed with acute renal injury (AKI).【Methods】 The clinical data of 104 patients with CHF and AKI aged ≥ 60 years in our hospital from July 2016 to March 2018 were analyzed retrospectively. According to the prognosis of patients who were followed up for 6 months, they were divided into good prognosis group (n=73) and bad prognosis group (n=31) The difference of serum NT proBNP and Cys-C levels in patients with different functional grades, and the influence of NT-proBNP and Cys-C levels on the prognosis of patients were collected and compared.【Results】 The levels of NT proBNP and Cys-C in patients with poor prognosis at admission were significantly higher than those in patients with good prognosis (P<0.05).The levels of NT-proBNP and Cys-C in patients with NYHA Ⅳ were significantly higher than those of patients with NYHA Ⅱ and Ⅲ, and the levels of NT -proBNP and Cys-C in patients with NYHA Ⅲ were significantly higher than those of patients with NYHA Ⅱ (P<0.05).The levels of NT proBNP and Cys-C in the dead subgroup were significantly higher than those in the non dead subgroup (P<0.05). The serum levels of NT-proBNP and Cys-C were the risk factors of poor prognosis in CHF patients with AKI (ORNT-proBNP=1.34,ORCys-C=1.49,all P<0.05); NT-proBNP, Cys-C and their combination predict the area under ROC curve of CHF patients with AKI was 0.676, 0.749 and 0.842, respectively.【Conclusion】Detection of serum NT-proBNP and Cys-C levels can better predict the prognosis of elderly patients with CHF with AKI, and the combined detection of them has a higher predictive value. 2020 Vol. 37 (1): 86-88 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 89 Changes of Plasma CTGF Level in Patients with CHF and its Correlation with BNP, Cardiac Function and Myocardial Remodeling FU Li-juan, WANG Ya-juan, ZHAO Xiao-jing,et al DOI: 10.3969/j.issn.1671-7171.2020.01.028 【Objective】To investigate the relationship between plasma connective tissue growth factor (CTGF) and plasma B-type natriuretic peptide (BNP), cardiac function and myocardial remodeling in patients with chronic heart failure (CHF).【Methods】From January 2016 to December 2017, 120 CHF patients (observation group) and 120 healthy volunteers (control group) were selected. The CTGF and BNP of the two groups were measured. The left ventricular end diastolic diameter (LVEDd), left atrial diameter (LAP), left ventricular posterior wall thickness (LVPW), left ventricular mass index (LVMI), left ventricular remodeling index (LVRI), cardiac output (CO) and left ventricular ejection fraction (LVEF) were measured. Linear regression was used to study the correlation between CTGF and each index.【Results】The levels of CTGF and BNP in the observation group were significantly higher than those in the control group (P<0.05). The levels of LVEDd, lap, LVPW, LVMI and LVRI in the observation group were higher than those in the control group, and the levels of CO and LVEF% in the observation group were significantly lower than those in the control group (P<0.05). In the observation group, there was a significant positive correlation between CTGF level and BNP, LVRI (rBNP=0.718,rLVRI=0.774, all P<0.05); there was a significant negative correlation between CTGF level and Co, LVEF% (rCO=-0.529,rLVEF=-0.577, all P<0.05).【Conclusion】The concentration of CTGF in CHF patients increases significantly, and CTGF expression is closely related to cardiac remodeling and cardiac function in CHF patients. 2020 Vol. 37 (1): 89-91 [Abstract] ( 83 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 92 Application of Ropacaine Nerve Block in Neurosurgery QIU De-liang, ZHANG Qiang, ZHAO Song-bo DOI: 10.3969/j.issn.1671-7171.2020.01.029 【Objective】To explore the clinical value of ropacaine nerve block in neurosurgery craniotomy.【Methods】A total of 98 patients who underwent carniotomy from October 2016 to December 2017 were randomly divided into group A and group B, with 49 cases in each group. Group A received ropacaine nerve block combined with intravenous general anesthesia, while group B only received intravenous general anesthesia. The heart rate (HR), mean arterial pressure (MAP), bispectral index (BIS) at different time points were recorded; postoperative pain (VAS) score, adverse reactions, serum substance P and serotonin (5-HT) before and after surgery were compared in the two groups. 【Results】At the time of T0~T3, there were no significant differences in values of HR, MAP and BIS between group A and the group B (P>0.05). The VAS scores at 4 h, 12 h, and 24 h after surgery in the observation group were significantly lower than those in the control group; and the difference were statistically significant (P<0.05). At 24 hours after operation, serum levels of substance P and 5-HT in group A were significantly lower than those in group B (P<0.05), though there were no significant difference before surgery. The incidence of adverse reactions in patients of group A was 6.12% (3/49) and that of group B was 12.24% (6/49), which did not show statistically significant (χ2=1.101,P=0.294>0.05).【Conclusion】 The use of ropacaine nerve block in neurosurgery craniotomy is beneficial to reduce postoperative pain and decrease serum substance P and 5-HT levels. 2020 Vol. 37 (1): 92-94 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 95 Expression of Slit2 and Robo1 Proteins and their Relationship with Microvessel Density in Pancreatic Carcinoma LIANG Gang, WANG Zhi-xiang, HE Meng-guo,et al DOI: 10.3969/j.issn.1671-7171.2020.01.030 【Objective】To investigate the expression of Slit2 and Robo1 proteins in pancreatic cancer and their relationship with microvessel density (MVD).【Methods】 Immunohistochemical staining SP method was used to detect the expression of Slit2 and Robo1 proteins in 30 cases of pancreatic cancer tissues and 30 cases of adjacent tissues. The expression changes of Slit2 protein and Robo1 protein under different clinicopathological conditions were observed. The microvessel density (MVD) marker CD105 was detected to study the relationship between Slit2 /Robo1 protein expression and MVD in pancreatic cancer. 【Results】The positive rates of Slit2 and Robo1 were 60.00% and 70.00% in pancreatic cancer tissues, respectively; and the positive rates in the adjacent tissues were 33.33% and 40.00%, respectively. The differences between the two types of tissues were statistically significant (P<0.05). There was a positive correlation between the positive expression of Slit2 protein and Robo1 protein (r=0.818, P< 0.05). The expression of MVD in pancreatic cancer tissues was higher than that in the adjacent tissues (t=9.475, P<0.05). The MVD in pancreatic cancer tissues with positive expression of Slit2 and Robo1 was much higher than that in pancreatic cancer tissues with negative expression of Slit2 and Robot1 (t=2.048, P<0.05,t=2.897, P<0.05). Expression of Slit2, Robo1 and MVD were significantly associated with tumor size, pathological type, clinical stage, and lymph node metastasis of pancreatic cancer (P<0.05).【Conclusion】 The increased expression of Slit2 protein and Robo1 protein in pancreatic cancer tissue is closely related to the growth, invasion and metastasis of pancreatic cancer. The mechanism may be that Slit2/Robo1 signaling pathway promotes the occurrence and development of pancreatic cancer by inducing tumor angiogenesis. The expression intensity of Slit2 /Robo1 and the enumerations of MVD can be used to predict the progression and prognosis of pancreatic cancer. 2020 Vol. 37 (1): 95-97 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 98 Correlation between Expression of Stimulator of Interferon Genes and Prognosis in Gastric Cancer Patients with Radical Resection DENG Feng, GONG Xiao-wei, YANG Jing DOI: 10.3969/j.issn.1671-7171.2020.01.031 【Objective】To explore the stimulator of interferon genes (STING) signaling in the development and prognosis of gastric cancer.【Methods】A total of 210 patients with gastric cancer who underwent surgical resection in our hospital were selected for the study. Immunohistochemistry was used to detect the STING expression in gastric cancer tissue and adjacent tissues of surgical resection. The follow-up data of patients were included. Then Kaplan-Meier and Log-rank tests were applied for analyzing the relationships between the prognosis and STING expression. Cox regression model was used to analyze the influencing factors of tumor-free survival time as well. 【Results】The positive rate of STING in gastric cancer tissues was higher than that in adjacent tissues (P<0.05). According to TNM staging, among those 210 patients, 55 cases were categorized in stage Ⅰ, 33 cases were in stage Ⅱ, 122 cases were in stage Ⅲ. Follow-up was completed in 195 patients accounting for 92.9% (195/210). Only 15 cases were lost to follow-up. The mean follow-up time was (39.8±10.5) months. The positive expression of STING were shown in 77 cases (36.7%, 77/210). Recurrence and metastasis occurred in 142 patients. Univariate analysis showed that larger tumors, higher staging (T stage, N stage and TNM stage) and positive STING expression increased the risk of recurrence in patients with gastric cancer treated by surgery [HR (95%CI):1.93 (1.42~2.84), 3.95 (2.61~5.84), 3.25 (2.17~4.86), 4.91 (3.63~7.52), 2.15 (1.33~3.53)]. Compared to patients with negative STING expression, Cox regression analysis showed that patients with positive STING expression had an increased risk of gastric cancer recurrence [HR: 1.98, 95% confidence interval (CI): 1.23~3.32].【Conclusion】 STING is proposed as a novel independent prognostic factor for gastric cancer. Patients with positive expression of STING have a higher risk of postoperative recurrence. 2020 Vol. 37 (1): 98-101 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 102 Correlation Analysis of MR Imaging Features and Clinical Stages in Patients with Hepatic Alveolar Echinococcosis JIANG Xue-lian DOI: 10.3969/j.issn.1671-7171.2020.01.032 【Objective】To investigate the relationship between magnetic resonance imaging and clinical stage in patients with hepatic alveolar hydatidosis (hepatic echinococcosis), in order to provide a theoretical basis for early diagnosis, treatment and improvement of prognosis of hepatic alveolar echinococcosis.【Methods】The imaging data of 74 patients with hepatic alveolar echinococcosis treated in the Department of Gastroenterology of our hospital from January 2010 to January 2018 were analyzed retrospectively. All patients received MRI scanning, and the MRI characteristics of the patients were analyzed and compared. According to Kodama classification principle, the lesions of hepatic alveolar echinococcus were divided into Kodama Ⅰ~Ⅴ types. The correlation between Kodama classification and the largest diameter of hepatic alveolar echinococcus was observed by Spearman correlation analysis model, and the correlation between different stages of PNM and the largest diameter of hepatic alveolar echinococcus was observed. 【Results】A total of 98 lesions with a diameter of 1.25~26.52 cm were found in 74 patients. 34 lesions in P1, 7 in P2, 53 in P3, 4 in P4, 82 in M0, 16 in M1, 53 in N0 and 45 in N1; Kodama Ⅲ and Ⅳ are the most common types in the lesions of echinococcosis, while Kodama Ⅰ, Ⅱ and Ⅴ were relatively few. Spearman's correlation analysis showed that there was a significant positive correlation between the maximum diameter of hepatic alveolar echinococcus and P stage (r=0.518, P<0.05); there was a significant positive correlation between the maximum diameter of hepatic alveolar hydatid focus and N stage (r=0.755, P<0.05); there was no correlation between the maximum diameter of hepatic alveolar hydatid focus and M stage (r=0.216,P>0.05); there was no correlation between the Kodama classification and the maximum diameter of hepatic alveolar hydatid focus (r=0.214,P>0.05).【Conclusion】Kodama Ⅲ and Ⅳ were the most common types in Kodama, P1, P3, M0 and N0 are the most common types in PNM, and there was a significant positive correlation between the maximum diameter of hepatic Echinococcus and P and N stages. 2020 Vol. 37 (1): 102-104 [Abstract] ( 104 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )

Copyright © Editorial Board of JOURNAL OF CLINICAL RESEARCH Supported by:Beijing Magtech