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| Value of DCE-MRI Semi-quantification in Predicting the Sensitivity of Lung Cancer to Concurrent Chemoradiotherapy |
| XIE Hong, CHEN Jian-ping, HE Jun-bin,et al |
| Department of Radiology,Changzhou Wujin People's Hospital, Changzhou 213002, China |
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Abstract 【Objective】To investigate the value of DCE-MRI semi-quantification in predicting the sensitivity of patients with lung cancer to concurrent chemoradiotherapy and relationship with tumor regression rate.【Methods】 A total of 83 lung cancer patients who underwent concurrent chemoradiotherapy in our hospital were selected.DCE-MRI scan was used to analyze the relationship of semi-quantitative parameters with tumor regression rate and chemoradiotherapy sensitivity prediction. The imaging quality of DCE-MRI images were also observed in this study. 【Results】The DCE-MRI image quality showed that there were 61 cases (74.50%), 20 cases (24.09%), 2 cases (2.41%), and 0 cases in grade 3, 2, 1 and 0, irrespectively. The sensitivity, specificity and accuracy of concurrent chemoradiotherapy sensitivity prediction by DEE-MRI were 84.6%, 83.9% and 80.4%, irrespectively, based on the ROC curve analysis (Ve=0.20). After 1 month of treatment, there were 43 cases in the sensitive group and 40 cases in the insensitive group. The TTP value in the sensitive group was lower than that in the insensitive group, while the SERmax value in the sensitive group was significantly higher than that in the insensitive group ; the difference was statistically significant (P<0.05) . The values of PET, MSI and MSD in the two groups were not significantly different (P> 0.05). The tumor area decreased gradually after radiotherapy and chemotherapy; and the tumor area at 3 months after treatment was (7.23±3.01)cm2, which was significantly lower than that before radiotherapy and chemotherapy, while the tumor regression rate presented a gradually increasing trend , the difference was statistically significant (P<0.05). Ktrans, a semi-quantitative parameter of DCE-MRI, was positively correlated with tumor regression rate in lung cancer patients before treatment (r=0.421, P=0.014), and Ve was negatively correlated with tumor regression rate (r=-0.881,P=0.000). Patients who had higher value of Ktrans before treatment showed lower value of Ve, indicating more sensitive to concurrent chemoradiotherapy.【Conclusion】 DCE-MRI semi-quantitative parameter analysis shows a high value in predicting the sensitivity of radiotherapy and chemotherapy for lung cancer. The image quality is also good. Thus it can guide the selection of chemotherapy drugs to achieve the final curative effect, which is worthy of wide application.
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Received: 19 September 2019
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2020, Vol. 37 
