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| Expression and Clinical Significance of IL-4, IL-6 and IL-8 in Serum of Patients with Chronic Obstructive Pulmonary Disease |
| ZHENG Ying-ni, ZHOU Yan-hua |
| Department of Respiratory Medicine, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China |
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Abstract 【Objective】To investigate the expression levels of interleukin-4 (IL-4), interleukin-6 (IL-6) and interleukin-8 (IL-8) in the serum of patients with chronic obstructive pulmonary disease (COPD) and their clinical significance.【Methods】From February 2017 to may 2018, 40 COPD patients (COPD group) and 40 healthy adults who received physical examination in the same period were selected as the control group. The levels of serum IL-4, IL-6, IL-8, TNF-α, pulmonary function indexes (FVC, FVC1, MMEF and PEF) and blood gas indexes (pH, PaCO2,PaO2) were compared between the two groups.The correlation of serum IL -4, IL-6 and IL -8 with TNF-α, lung function and blood gas were analyzed. 【Results】The levels of IL-4, IL-6, IL-8 and TNF -αin the COPD group were higher than those in the control group (P<0.05); the levels of FVC, FVC1, MMEF and PEF in the COPD group were lower than those in the control group (P<0.05); the levels of pH and PaO2 in the COPD group were lower than those in the control group (P<0.05);the level of PaCO2 was higher than that of the control group (P<0.05); the levels of IL-4, IL-6 and IL-8 in the COPD group were positively correlated with the levels of TNF -αand PaCO2 , and FVC, FVC1, MMEF, PEF, pH and PaO2 were negatively correlated.【Conclusion】The serum levels of IL-4, IL-6 and IL-8 are higher in COPD patients, and are closely related to lung function and blood gas index.
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Received: 10 October 2018
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[1] 钟萍, 范贤明, 蒋雪莲,等. COPD稳定期患者血清IL-6、IL-18、CC16水平与肺功能及CAT评分的关系[J]. 实用医学杂志, 2016, 32(21):3547-3551.
[2] 晏斌林, 顾为丽, 杜娟,等. 慢性阻塞性肺疾病患者呼出气冷凝液IL-17、IL-10、8-iso-PG的测定及临床意义[J]. 中国呼吸与危重监护杂志, 2017,11(2):142-146.
[3] 吴春婷, 赵佳晖, 魏东,等. 肺功能对合并慢性阻塞性肺疾病患者心脏外科手术预后的影响[J]. 中华结核和呼吸杂志, 2017, 40(2):86-89.
[4] 张荣葆, 谭星宇, 陈清,等. 胸外科住院肺癌合并慢性阻塞性肺疾病的调查结果分析[J]. 中国肺癌杂志, 2017, 20(3):163-167.
[5] Sharan R, Perez-Cruz M, Kervoaze G, et al. Interleukin-22 protects against non-typeable Haemophilus influenzae infection: alteration during chronic obstructive pulmonary disease[J]. Mucosal Immunol, 2017, 10(1):139-149.
[6] 姚伦凯, 柳广南, 黄斯明,等. 肺腺癌组织中HDAC2、IL-8、TNF-α的表达及其与吸烟的关系[J]. 中华医学杂志, 2016, 96(18):1410-1413.
[7] 蒋雪莲, 钟萍, 黄成亮,等. 稳定期慢性阻塞性肺疾病患者营养状况和氧化应激能力与肺功能的关系[J]. 中华结核和呼吸杂志, 2017, 40(1):40-45.
[8] 姚伦凯, 柳广南, 黄斯明,等. 烟草烟雾暴露对肺腺癌患者外周血HDAC2、IL-8和TNF-α表达的影响[J]. 中国呼吸与危重监护杂志, 2016,18(4):361-364.
[9] 潘明鸣, 张洪胜, 孙铁英. 老年男性支气管哮喘-慢性阻塞性肺疾病重叠综合征患者肺功能特征分析[J]. 中华老年医学杂志, 2017, 36(2):146-150. |
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2020, Vol. 37 
