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| Effect of Risperidone Combined with Sertraline on sTNFRs and Neuroelectrophysiological Characteristics in Schizophrenic Patients with Negative Symptoms |
| CHANG Xiao-juan, YANG Xiao-long,GAO Cheng-ge |
| Hanzhong Central Hospital,Hanzhong 723000 |
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Abstract 【Objective】To investigate the clinical effects of risperidone combined with sertraline in patients with schizophrenia-negative disease and its effects on soluble tumor necrosis factor receptor (sTNFRs) and neurophysiological characteristics.【Methods】The clinical data of 68 schizophrenic negative patients admitted to our hospital from May 2016 to November 2017 were analyzed retrospectively. They were divided into control group (risperidone) and observation group (risperidone combined with sertraline) according to different medication methods, 34 cases each. After 3 months of treatment, the negative symptoms, sTNFRs and electrophysiological characteristics of the two groups were compared.【Results】Three months after the treatment, the scores of emotional retardation, social disorder, personality isolation, frequent thinking and communication disorder in the observation group were lower than those in the control group, with statistical significance (P<0.05). The level of sTNFRs in the observation group was lower than that in the control group at 1, 2 and 3 months after treatment (P<0.05). After treatment, P300, N250 and ERN of the two groups were higher than before treatment, LPP amplitude was lower than before treatment; P300, N250 and ERN amplitude of the observation group were higher than that of the control group, LPP amplitude was lower than that of the control group, the difference was statistically significant (P<0.05).【Conclusion】Risperidone combined with sertraline in the treatment of negative schizophrenia can improve the symptoms, reduce the level of sTNFRs and improve the characteristics of neuroelectrophysiology, which is worth popularizing.
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Received: 12 November 2018
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2020, Vol. 37 
