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Quick Search     Adv Search 2018 Vol. 35, No. 11 Published: 2018-11-30   2081 Expression and Significance of FcεRIγ Subunit and its Acetylation in Mononuclear Cells of Patients with Atopic Dermatitis TANG Jin-ling, LONG Hai, LUO Yong-qi DOI: 10.3969/j.issn.1671-7171.2018.11.001 【Objective】To investigate the expression of IgE high-affinity receptor γ subunit (FcεRIγ subunit) in the mononuclear cells of patients with atopic dermatitis (AD) and its regulation effect of acetylation level. 【Methods】 Twenty-three cases of AD patients (AD group) and 12 healthy volunteers (control group) were selected from the Dermatological Department of the Second Xiangya Hospital of Central South University, and the peripheral blood was collected from all subjects, and mononuclear cells were isolated, and the mononuclear cells from the control group was treated with the acetyltransferase inhibitor, trichostatin A (TSA), and the real-time fluorescence was used to detect the expression of FcεRIγ subunit in mononuclear cells, the expression of FcεRI on the surface of mononuclear cells was detected by flow cytometry; chromatin immunoprecipitation (CHIP) PCR was used to analyze the expression of histone H3 acetylation (ac-histone H3) in the promoter region of FcεRIγ subunit; Pearson correlation analysis was used to analyze the correlation between FcεRIγ subunit, FcεRI with FcεRI subunit ac-histone H3. 【Results】Compared with the control group, the expression of FcεRIγ subunit mRNA in the peripheral blood mononuclear cells of the control group +TSA treatment group and the AD group increased, the proportion of FcεRI cells and the average fluorescence intensity increased; and the FcεRIγ subunit ac-histone H3 mRNA expression increased (P<0.05). Pearson correlation analysis showed that FcεRIγ subunit and FcεRI were positively correlated with FcεRIγ subunit ac-histone H3. 【Conclusion】The FcεRIγ subunit gene of monocyte in AD patients can regulate the sequence acetylation, and promote the up-regulated expressions of FcεRIγ subunit and FcεRI on the surface of mononuclear cells, thus participating in the occurrence and development of AD. 2018 Vol. 35 (11): 2081-2084 [Abstract] ( 88 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2085 Clinical Observation of Nabuphine in the Prevention of Urinary Catheter-related Bladder Irritation in Adult Males LUO Feng, TANG Yi-xun, CHEN Wen-Yan,et al DOI: 10.3969/j.issn.1671-7171.2018.11.002 【Objective】To observe the effects of different doses of nabuphine on urinary catheter-related bladder stimulation(CRBD) in adult males.【Methods】A total of 90 cases of adult male patients in general surgery undergoing elective surgery were selected and randomly divided into the control group (group C with saline,n=30), nabuphine group A ( 0.1 mg/kg) and nabuphine group B ( 0.2mg/kg). Intravenous infusion of saline or naborphine was administrated 5 min before catheter placement. The severity of CRBD and the pain visual analogue scale (VAS score) were recorded 1 min after urethral catheter implantation. The incidence of CRBD and adverse reactions such as sedation, hyperhidrosis, nausea and vomiting within 30 minutes after catheter placement were compared among the three groups.【Results】Compared to group C, CRBD degree and VAS scores of group A and group B 1 min after catheter placement were lower (P＜0.05). Furthermore, those of group B were even lower than those of group A(P＜0.05). There was no statistically significant difference in the incidence of polyperspiration, nausea or vomiting among the three groups (P＞0.05). The incidence of CRBD in group A and group B was lower than that in group C, and the sedation rate was higher than that in group C (P＜0.05). The incidence of CRBD in group B was lower than that in group A, and the sedation rate was higher than that in group A.【Conclusion】 Nalbuphine dose at 0.2mg /kg can be effectively used to prevent adult male CRBD. 2018 Vol. 35 (11): 2085-2086 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 2087 Analysis of the Present Situation and Influencing Factors of Local Drug Use in the Eyes of Inpatients with Ophthalmopathy LI Chun-yan, LIN Huan, DAI Min-hui DOI: 10.3969/j.issn.1671-7171.2018.11.003 【Objective】To investigate the current situation and influencing factors of local drug use in ophthalmopathy patients in a hospital, to provide basis for clinical improvement of health education model.【Methods】A self-designed questionnaire was used to analyze the knowledge-attitude-behavior of local drug use in 156 patients with eye diseases in a Grade 3A hospital.【Results】The scores of knowledge dimension were excellent (33.33%), positive attitude (25.64%) and positive behavior (26.28%). There were significant differences between different education level and hospitalization days on the scores of knowledge (P<0.05), no effect on the scores of attitude and behavior was observed(P>0.05), and gender only had influence on the scores of behavior (P<0.05). Age, occupation, marital status, financial status, long-term residence were not correlated with local medication and knowledge, belief and practice (P>0.05).【Conclusion】 The related knowledge, attitude and behavior of local drug use in ophthalmopathy patients are still insufficient, especially in the aspects of eye drop technique and its management. It is suggested that the health education model of local safe drug use should be established for the patients with eye diseases. 2018 Vol. 35 (11): 2087-2090 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 2091 Effect of Three-dimensional Reconstruction on Minimally Invasive Precise Hepatectomy Operation for Right Hepatic Hepatectomy ZHANG Yan, XIANG Guo-an, YUAN Qing-gong, et al DOI: 10.3969/j.issn.1671-7171.2018.11.004 【Objective】To investigate the effect of three-dimensional reconstruction on minimally invasive precise hepatectomy operation for right hepatic hepatectomy. 【Methods】The clinical data of 64 patients with right hepatectomy were selected and divided into observation group (n=38, used before operation) and control group (n=26, unused before operation). The operative time, the intraoperative blood loss, the blocking time of the hepatic gate, the actual resection of the liver volume, the postoperative hospital stay and the postoperative complications were recorded.【Results】 The operative time, intraoperative bleeding volume, hepatic portal occlusion time and hospitalization time in the observation group were significantly lower than those in the control group (P<0.05).The actual liver resected liver volume of the observation group was slightly smaller than that of the preresectomized liver, and the difference was not statistically significant (P>0.05).The results of linear correlation analysis showed that there was a significant correlation between the volume of preresectomized liver and the actual volume of liver resected (r=0.925,P<0.01).There were 3 cases in the observation group and 2 cases in the control group which developed peritoneal effusion after operation and were cured by drainage.No CO2 embolism, biliary fistula, bleeding and other complications occurred in both groups.【Conclusion】 Three-dimensional reconstruction and simulated hepatectomy system can reduce the time of laparoscopic hepatectomy, the amount of intraoperative bleeding, the time of hepatic hilus occlusion and postoperative hospitalization time, which can accurately predict the tumor volume. It has a certain auxiliary effect in laparoscopic hepatectomy. 2018 Vol. 35 (11): 2091-2093 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2094 Effect of Anterior Cervical Single-cage Bone Graft Fusion Combined with Internal Fixation for the Treatment of Cervical Spinal Cord Injury without Fracture and Dislocation QIAO Lin, ZHANG Huan, CHEN Bo,et al DOI: 10.3969/j.issn.1671-7171.2018.11.005 【Objective】To explore the therapeutic effect of anterior cervical single-cage bone graft combined with internal fixation for the treatment of cervical spinal cord injury without fracture and dislocation. 【Methods】Retrospective analysis of the clinical data of 216 patients with cervical spinal cord injury without fracture and dislocation in our department. According to the treatment method, the patients were divided into the operation group (anterior cervical single-cage bone graft combined with internal fixation,n=120 cases) and the conservative treatment group (skull traction, nutritional nerves,n=96 cases.). The clinical effects of the two groups before and after treatment were compared. 【Results】All the 120 patients in the operation group successfully completed the operation. The operation time was (97.2±14.0) min, the amount of surgical bleeding was (128.9±77) mL, and the bone graft fusion time was (12.4±2.2) weeks. Before treatment, there were no significant differences in the scores of the American Spinal Injury Association (ASIA) and the Japan Orthopaedic Association (JOA) scores between the two groups (P>0.05). After 12-months treatment, the excellent rate of neurological function in the operation group was 63.33% (76/120), which was significantly higher than that of the conservative group 47.92% (46/96) (χ2=4.529,P<0.05). The total score of JOA in the operation group was significantly higher than that of the conservative group (P<0.05). After 12 months of follow-up, no postoperative complications such as graft non-fusion, cage translocation or subsidence, plate internal fixation displacement or loosening, fracture dislocation or loss of reduction were found in the operation group. However, secondary spinal cord injury and side effects such as stagnation or regression occurred in the conservative group. 【Conclusion】Anterior cervical single-cage bone graft combined with internal fixation for the treatment of cervical spinal cord injury is superior to the conservative non-surgical treatment in aspect of the recovery of spinal cord function and complications. 2018 Vol. 35 (11): 2094-2096 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2097 Clinical Study on Taxol Combined with Carboplatin in Treating Epithelial Ovarian Cancer LI Cheng-liang, XIN Hong, WANG Min-juan,et al DOI: 10.3969/j.issn.1671-7171.2018.11.006 【Objective】To explore the clinical efficacy of taxol combined with carboplatin on epithelial ovarian cancer. 【Methods】 A total of 80 patients with epithelial ovarian cancer admitted in our hospital from August 2015 to July 2017 were divided into two groups on the basis of random number table, with 40 cases in each group. The observation group was treated with the combination of taxol and carboplatin, while the control group received carboplatin only. Both groups were treated continuously for 2 courses, each lasting 2 weeks. The clinical efficacy, adverse reactions, changes of tumor markers [carbohydrate antigen (CA) 199, CA125, CA153, carcino-embryonic antigen (CEA)], and immune function indicators [CD3+T ratio, CD4+ ratio, CD8+ T ratio and CD4+/CD8+ value] as well as Karnofsky performance status (KPS) scores were compared between the two groups before and after treatment between the two groups. 【Results】The effective rate of the observation group was 82.50% (33/40),which was much higher than that of the control group 57.50% (23/40) (P<0.05). The incidence of adverse reactions of the observation group was 27.50% (11/40) and that of the control group was 22.50% (9/40). The difference in the incidence of adverse reactions between the two groups was not statistically different (P>0.05). After treatment both groups obtained significantly lower content of serum CA199, CA125, CA153, CEA and lower peripheral blood CD3+, CD4+, CD4+/CD8+ values (P<0.05). On the other hand, the proportion of CD8+ in peripheral blood was significantly increased (P<0.05). The serum levels of CA199, CA125, CA153, CEA and CD8+ in the observation group were significantly lower than those in the control group (P<0.05), and the peripheral blood CD3+, CD4+ ratio and CD4+/CD8+ values were significantly increased (P<0.05). The KPS score of the observation group 3 months after treatment was obviously higher than that before treatment (P<0.05), but there was no significant change before and after chemotherapy in the control group (P>0.05). 【Conclusion】 The combination of taxol and carboplatin in treating epithelial ovarian cancer can significantly lower the expression levels of serum tumor markers, regulate cellular immune function and improve patients' life quality, which is worthy of clinical application. 2018 Vol. 35 (11): 2097-2100 [Abstract] ( 51 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 2101 Correlation between Body Fat Distribution and Blood Lipid Metabolism in Patients with Coronary Heart Disease JIAO Si-yu, CUI Yu-jie, JI Mei-jing, et al DOI: 10.3969/j.issn.1671-7171.2018.11.007 【Objective】To explore the correlation between body fat distribution and blood lipid metabolism in patients with coronary heart disease. 【Methods】A total of 70 coronary heart disease patients (the observation group) and 80 healthy volunteers ( the control group ) from June 2015 to June 2017 were enrolled in this study. Body fat composition and bone mineral density (BMD) were measured by dual-energy X-ray absorptiometry (DEXA). The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and uric acid (UA) were compared between the two groups. The correlation between body fat distribution and lipid metabolism was analyzed in the coronary heart disease group. 【Results】There was no significant difference in age and BMI between the observation group and the control group (P>0.05). The levels of serum TG, TC, LDL-C and UA in the observation group were significantly higher than those in the control group (P<0.05), but the serum HDL-C levels were not significantly different (P>0.05). There was no significant difference in height and body weight between the observation group and the control group (P>0.05). The waist circumference, SBP and DBP in the observation group were significantly higher than the control group (P<0.05). The fat mass of the observation group was significantly higher than that of the control group, while the muscle mass, BMC and BMD were significantly lower than those of the control group (P<0.05). BMD and BMC were positively correlated with overall muscle mass, total fat mass, TG, TC and LDL-C (P<0.05).【Conclusion】Coronary heart disease has significant regression with fat mass, muscle mass, BMC and BMD, suggesting that body composition distribution and dyslipidemia play an important role in the occurrence and development of coronary heart disease. 2018 Vol. 35 (11): 2101-2103 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 2104 Analysis of Stress, Depression and Tobacco and Alcohol Use of Mental Health Workers in Township Health Centers of Hunan Province DONG Xuan-qi, ZHOU Xu-hui DOI: 10.3969/j.issn.1671-7171.2018.11.008 【Objective】To explore the relationship between stress, depression and tobacco and alcohol use of mental health workers in township health centers of Hunan province.【Methods】From December 28, 2013 to January 13, 2014, 1 700 trainees who attended the training course of mental disease prevention and control in Hunan township health center were investigated. A total of 1546 students completed the scale and recovered it. The self-made tobacco and alcohol use questionnaire and life event scale (LES) and Beck Depression scale (BDI) were used to evaluate.【Results】The types of drinking, the frequency of weekly drinking, the amount of alcohol consumed and the number of smoking per day in males were significantly higher than those in females (P<0.001), and the scores of male stress and depression were significantly higher than those of females (P<0.001). There was a significant positive correlation between daily smoking and age, weekly drinking times, and alcohol consumption (P<0.05). Stress was negatively correlated with age (P<0.05), positively correlated with alcohol consumption and daily smoking (P<0.05), depression was negatively correlated with age (P<0.05), and positively correlated with the number of times of drinking per week, the amount of alcohol consumed once a week, the amount of daily smoking and the pressure(P<0.05). The frequency of drinking alcohol per week, the amount of alcohol consumed once were correlated with the stress and depression (P<0.05).【Conclusion】The stress and depression scores of mental health workers in township health centers of Hunan Province are all high, and the use of alcohol and tobacco is common. It is necessary to improve the working environment of employees, improve their working treatment, and promote the physical and mental health of grass-roots workers. 2018 Vol. 35 (11): 2104-2106 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 2107 Therapeutic Effect of IMRT and 3D-CRT in Patients with Early NSCLC and Its Influence on Tumor Markers and Immune Function HE Dong-cheng, HAN Ji-hua, CAO Lei,et al DOI: 10.3969/j.issn.1671-7171.2018.11.009 【Objective】To analyze the effect of stereotactic body radiotherapy [SBRT: intensity-modulated radiation therapy (IMRT) and 3-D conformal radiotherapy (3D-CRT)] in patients with early non-small cell lung cancer (NSCLC) and its influence on tumor markers and immune function. 【Methods】A total of 66 patients with early NSCLC in our hospital were selected from Oct. 2014 to Feb. 2018 and were randomly divided into group A (n=33) and group B (n=33). Group A was treated with IMRT and group B was treated with 3D-CRT. The therapeutic effects of the two groups were compared. Also, effects on serum carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), carcinoembryonic antigen (CEA) and T lymphocyte subsets CD3+, CD4+, CD4+/CD8+ index levels were compared. 【Results】 The total effective rate of group A (78.79%) was significantly higher than that of group B (78.79% vs 54.55%, χ2=4.364,P<0.05). After treatment, the serum levels of CA125, CA153 and CEA in the two groups were significantly lower than those before treatment (P<0.05),and those levels in group A were significantly lower than group B (P<0.05); After treatment, the serum levels of CD3+, CD4+, CD4+/CD8+ in the two groups were significantly lower than before treatment, and those levels in group B were significantly lower than group A (P<0.05). 【Conclusion】SBRT has good therapeutic effect on patients with early NSCLC. The effect of IMRT is better than that of 3D-CRT, and it can reduce the immune function of the body. 2018 Vol. 35 (11): 2107-2109 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2110 Association between Memory Impairment and Levels of Inflammatory Cytokines and Lipid in Neurosyphilis Patients SHEN Yi-ping, CHEN Xiu-min DOI: 10.3969/j.issn.1671-7171.2018.11.010 【Objective】To explore the association of memory impairment in neurosyphilis patients with levels of inflammatory cytokines and serum lipids. 【Methods】A total of 114 patients with neurosyphilis were in group A and 120 healthy volunteers as controls were in group B. The psychological background and memory ability of the two groups were compared. According to the memory function impairment, 114 syphilis patients were divided into group A1 (with memory impairment) and group A2 (without impairment) . Levels of inflammatory cytokines and serum lipids were compared in both groups. 【Results】The scores of mini-mental state scale (MMSE), Digital Spanning Test (DS) and Auditory Words Learning Test (AWLT) of group A were significantly lower than those of group B (P<0.05). There was no significant difference in the scores of verbal fluency test (VFT) between group A and group B (P>0.05). The time-based and event-based memory scores of group A were significantly lower than those of group B, and the difference was statistically significant (P<0.05). The levels of TNF-α and IL-6 in group A1were significantly higher than those in group A2; while the level of IL-10 of A1 group was significantly lower than that of A2 group (P<0.05). Serum total cholesterol (TC), glyceryl triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels were significantly higher in group A1 than in group B and A2 (P<0.05). There were no significant differences in the levels of HDL-C, ApoA, and ApoB among all groups (P>0.05). 【Conclusion】The mental and memory abilities of syphilis patients are significantly impaired compared to the normal population, and memory impairment is associated with inflammatory factor levels and lipid metabolism. 2018 Vol. 35 (11): 2110-2112 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2113 Effect of Losartan Combined with Alprostadil on Treatment of Hypertension with Renal Injury TAO Lin, LIANG Jun, MA Yu-yan DOI: 10.3969/j.issn.1671-7171.2018.11.011 【Objective】To investigate the effect of losartan combined with alprostadil on treatment of hypertension with renal injury. 【Methods】From March 2015 to March 2017, 82 patients with hypertension complicated with renal damage [urinary microalbumin and urinary creatinine ratio (UACR) > 30 mg/g] were divided into observation group and control group according to the random number method, 41 cases in each group.The observation group was treated with losartan and alprostadil for 16 weeks.Blood pressure, renal function and coagulation function were measured before and after treatment.【Results】After treatment, the serum creatinine (Scr),β2-microglobulin (β2-MG) ,SBP, diastolic blood pressure (DBP), UACR in both groups was significantly lower than those before treatment, and the creatinine clearance rate (Ccr) was significantly increased. SBP,DBP,UACR, Scr were lower than those of the control group, Ccr was significantly higher than that in control group (P<0.05).After treatment, the level of fibrinogen (FIB), D-D dimer (D-D) in the observation group was lower than that before treatment, and the FIB,D-D in the observation group was significantly lower than that in the control group (P<0.05).There was no significant difference in thromboplastin time (APTT) between the two groups before and after treatment (P>0.05). 1 case of nausea and 1 case of dizziness occurred in the observation group, the incidence rate was 4.87%(2/41).【Conclusion】Compared with Losartan alone, losartan combined with alprostadil can effectively protect renal function in patients with hypertension complicated with renal injury. 2018 Vol. 35 (11): 2113-2114 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2115 Clinical Application of Laparoscopic Left Hepatectomy for Treatment of Intrahepatic Bile Duct Stones observed LUO Si-man, DU Gang DOI: 10.3969/j.issn.1671-7171.2018.11.012 【Objective】To investigate the clinical effect of laparoscopic left hepatectomy for intrahepatic bile duct stones.【Methods】The clinical data of 87 patients with intrahepatic bile duct stones admitted to our hospital from January 2013 to December 2017 were retrospectively analyzed. Among them, 42 cases were treated with laparoscopic left hemihepatectomy (the observation group) and 45 cases were treated with open abdominal left hemihepatectomy (the control group). The intraoperative and postoperative indicators, liver function index before and 3 days after operation , the residual rate of stones and complications of the two groups were compared. 【Results】The blood loss, intraoperative blood transfusion rate and incision length in the observation group were less than those in the control group (P<0.05). However, the operation time of the observation group was longer than that of the control group (P<0.05).Postoperative pain relief, hospitalization, anal exhaust time, bowel function recovery time and visual analogue scale (VAS) were better in the observation group than those in the control group (P<0.05).There was no significant difference in the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) between the two groups before operation (P>0.05).The levels of AST and ALT in both groups increased on the 3rd day after operation, but the increase in the observation group was less than that in the control group (P<0.05).There were no significant differences between the two groups in terms of the residual rate of stone and the incidence of complications one week after operation (all P>0.05). 【Conclusion】Laparoscopic left hepatectomy for patients with the treatment of intrahepatic bile duct stones can not only ensure clinical efficacy, but also significantly reduce the amount of intraoperative bleeding, reduce pain in patients with less trauma and allow patients to recover faster. 2018 Vol. 35 (11): 2115-2117 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2118 Significance of Serum Adiponectin Combined with CA19-9 in the Diagnosis of Pancreatic Cancer SHI Wei, TAN Chao-chao, XIE Liang-yi,et al DOI: 10.3969/j.issn.1671-7171.2018.11.013 【Objective】To research on the significance of serum adiponectin and CA19-9 joint test in diagnosis of pancreatic cancer.【Methods】The levels of CA19-9 and adiponectin in 60 patients with pancreatic cancer, 90 patients with chronic pancreatitis and 40 healthy people were measured from January 2016 to February 2018 to evaluate the diagnostic value of alone and combined detection for pancreatic cancer to evaluate the diagnostic value of alone and combined detection for pancreatic cancer. 【Result】Compared with the group of chronic pancreatitis, the level of CA19-9 and adiponectin in pancreatic cancer group were significantly increased, and the diagnostic value of CA19-9 combined with adiponectin in the diagnosis of pancreatic cancer was higher than that in any single index. The sensitivity and specificity were 88.30% and 85.60%, respectively.【Conclusion】The combined detection of adiponectin and CA19-9 is helpful for the detection and diagnosis of pancreatic cancer. 2018 Vol. 35 (11): 2118-2120 [Abstract] ( 45 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2121 Clinical Observation of Azithromycin Combined with Montelukast in the Treatment of Cough Variant Asthma with Mycoplasma Pneumoniae Infection in Children ZHANG Xiao-hong, LI Ling-mei DOI: 10.3969/j.issn.1671-7171.2018.11.014 【Objective】To investigate the efficacy of azithromycin combined with montelukast in the treatment of children of cough variant asthma (CVA) with Mycoplasma pneumonia (MP) infection . 【Methods】A total of 120 cases of children diagnosed with CVA and MP infection were selected for the study and divided into two groups with 60 cases in each group according to the random table method. The control group (B group) was treated with azithromycin, while the observation group (A group) was additionally given montelukast on the basis of azithromycin treatment. The treatments in both groups lasted 7 days. After the course of treatment, the clinical efficacies of the two groups were observed and the serum levels of inflammatory factors and immunoglobulins were compared between the two groups before and after treatment. Adverse reactions were recorded as well. 【Results】The total effective rate was 83.3% in B group, which was significantly lower than that in A group with 95.0% (P<0.05). The levels of ECP, IL-5, MMP-9,TIMP-1 and IgE , and EOS in the two groups were significantly lower than those before treatment (P<0.05) and the indexes in A group after treatment were significantly lower than those in B group (P<0.05). The cough disappearance time, wheezing disappearance time, temperature recovery time in B group were significantly better than those in A group. The overall incidence rate of adverse reactions was 11.67%(7/60)in B group, which was not significantly different from that in A group with 8.33%( 5/60) (P>0.05). 【Conclusion】Azithromycin combined with montelukast can have a significant clinical efficacy, can reduce airway hypersensitivity and airway inflammation, and promote rehabilitation of children in the treatment of CVA with MP infection. 2018 Vol. 35 (11): 2121-2123 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2124 Changes of Inflammatory Factors and Renal Function with Febuxostat Treatment in Male Patients of Gout Complicated with Hyperuricemia LI Yong-gang DOI: 10.3969/j.issn.1671-7171.2018.11.015 【Objective】To explore the changes of inflammatory factors, renal function and febuxostat treatment in male patients with gout and hyperuricemia (HUA). 【Methods】A total of 90 patients with hyperuricemia who were diagnosed and met the criteria in our hospital were selected from April. 2017 to May. 2018. According to the presence of gout, patients were divided into the gout group(n=45) and the non-gout group(n=45). Meanwhile, a total of 45 healthy volunteers who had physical examinations at the same time period were selected as the healthy control group. The changes of inflammatory factors [Hypersensitivity reaction protein (hs-CRP), Interleukin-6 (IL-6)] and renal function [Blood urea nitrogen (BUN), Serum creatinine (SCr), Blood uric acid (SUA), Glomerular filtration rate(eGFR)] were compared among the three groups. The gout group was treated with febuxostat, and the changes of inflammatory factors and renal function were compared before and after three month treatment. 【Results】Levels of hs-CRP, IL-6, SCr, SUA, and eGFR showed statistically significant difference among three groups(P<0.05). However, there were no significant differences in BUN level(P>0.05). Significant differences in SCr, SUA, and eGFR were shown between the gout group and the control group(P<0.05)and there was significant difference of SUA level between the non-gout group and healthy control group(P<0.05). After treatment, the serum levels of hs-CRP, IL-6 and SUA in the gout group were significantly lower than those before treatment and the differences were statistically significant(P<0.05). However,the changes of BUN, SCr and eGFR were not significantly different (P>0.05). 【Conclusion】The serum levels of hs-CRP, IL-6, SCr, SUA,and eGFR were significantly increased in male patients with gout complicated with hyperuricemia. The application of febuxostat can reduce the level of SUA. The clinical efficacy was satisfactory and it is worthy of clinical promotion. 2018 Vol. 35 (11): 2124-2126 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 2127 Effect of Transcranial Direct Current (tDCS) Stimulation on Post-stroke Depression (PSD) and the Expression of 5-Hydroxytryptamine (5-HT) SU Mou-xiao, YAO Li-ying, CHEN Zhong-lun,et al DOI: 10.3969/j.issn.1671-7171.2018.11.016 【Objective】To investigate the effect of transcranial direct current (tDCS) stimulation on poststroke depression (PSD) and the expression of 5-hydroxytryptamine (5-HT).【Methods】From October 2016 to May 2017, 47 patients with PSD were randomly divided into observation group (n=24) and control group (n=23). The observation group was treated with true tDCS and the control group with false tDCS for 8 weeks. Before treatment and 7 days , 14 days and 8 weeks after treatment, neurologic function was assessed by the National Institutes of Health Stroke score (NIHSS), The 17-item Hamilton Depression Rating scale (HDRS) and the Montgomery Depression scale ( MADRS) were used to assess depression in patients. High performance liquid chromatography (HPLC)-fluorescence assay was used to detect plasma Glu,5-HT levels in both groups before and after treatment.【Results】Before treatment, there was no significant difference in NIHSS,HDRS,MADRS score, plasma Glu and 5-HT concentration between the two groups (P>0.05). After 8 weeks of treatment, the NIHSS,HDRS,MADRS score of the patients in the observation group decreased significantly, and the plasma 5-HT level increased, while Glu decreased. The difference was statistically significant compared with that of the control group (P<0.05).【Conclusion】 TDCS may play a better role in the treatment of PSD patients by regulating the Glu and 5-HT pathway. 2018 Vol. 35 (11): 2127-2129 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 21 ) 2130 Effects of Ultrasound-guided Fascia Iliac Compartment Block Combined with General Anesthesia in Femoral Surgery WU Bo DOI: 10.3969/j.issn.1671-7171.2018.11.017 【Objective】To investigate the application effect of ultrasound-guided fascia iliac compartment block (FICB) combined with general anesthesia in femoral surgery. 【Methods】A total of 88 patients undergoing femoral surgery were randomly divided into two groups. Patients in the observation group were given ultrasound guided FICB combined with general anesthesia, while patients in the control group were given only general anesthesia. Hemodynamic changes during the perioperative period, scores of VAS in resting and moving states at different time points, anesthetic effects and related complications were compared between the two groups. 【Results】MAP and HR of the observation group at 5min after skin incision were significantly lower than those of the control group (P<0.05). VAS scores in the observation group at 2h, 6h and 12h of resting and moving states after surgery were significantly lower than those of the control group (P<0.05). The amount of propofol, the dose of remifentanil, the extubation time and the duration of complete recovery were significantly better in the observation group than in the control group (P<0.05). There were no significant differences in the incidence of nausea, vomiting and pruritus between the two groups (P>0.05). 【Conclusion】 Ultrasound-guided FICB combined with general anesthesia can maintain stable vital signs of patients undergoing femoral surgery and reduce the dose of related anesthetic drugs. The analgesic effect is definitely good and postoperative recovery time is short. 2018 Vol. 35 (11): 2130-2132 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 2133 Clinical Effect of Yangzhengxiaoji Capsule Combined with Pemetrexide and Carboplatin in the Treatment of EGFR Wild-type or Unknown Metastatic Lung Adenocarcinoma ZHAN Juan, FU Jian-guo, SONG Min,et al DOI: 10.3969/j.issn.1671-7171.2018.11.018 【Objective】To investigate the clinical effect of Yangzhengxiaoji capsule combined with pemetrexide and carboplatin in the treatment of EGFR wild-type or unknown metastatic lung adenocarcinoma. 【Methods】 The clinical data of 48 patients with EGFR wild type or unknown status of metastatic lung adenocarcinoma were selected. The patients were randomly divided into observation group and control group with 24 cases in each group.The observation group was treated with Yangzhengxiaoji capsule combined with pemetrexide and carboplatin chemotherapy, while the control group was treated with the placebo of Yangzhengxiaoji capsule combined with pemetrexide and carboplatin chemotherapy.Adverse reactions were observed in the two groups, and the clinical efficacy and quality of life (QOL) were evaluated after 2 cycles. 【Results】There was no complete remission of (CR) in both groups.The objective effective rate (ORR) of the observation group was 33. 3%(8/24).The disease control rate (DCR) was 83.3% (8/24), the ORR of the control group was 25.5%(6/24), DCR=66.7%(16/24), there was no significant difference between the two groups (mean P>0.05).The main adverse reactions in the two groups were bone marrow suppression, digestive tract reaction and fatigue, most of which were grade 1 or 2. No grade 4 or 5 adverse reactions occurred in both groups.The incidence of neutropenia, nausea, vomiting, liver function damage and fatigue in the observation group was significantly lower than that in the control group (P<0.05).【Conclusion】 Yangzhengxiaoji capsule combined with pemetrexide and carboplatin in the treatment of EGFR wild-type or unknown senile metastatic lung adenocarcinoma has a good clinical effect, can significantly reduce or alleviate the adverse reactions associated with chemotherapy, and can significantly improve and stabilize the symptoms of patients,improve the quality of life.Thus,it is worth popularizing in clinic. 2018 Vol. 35 (11): 2133-2135 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2136 Clinical Study of Lidocaine in the Treatment of Refractory Renal Colic SHENG Bin, LIU Jun, YI Dan DOI: 10.3969/j.issn.1671-7171.2018.11.019 【Objective】To investigate the clinical efficacy of lidocaine in the treatment of refractory renal colic in the emergency department. 【Methods】A total of 80 patients with renal colic whose VAS pain scores were still greater than 8 points after receiving non-steroidal anti-inflammatory drug and the smooth muscle spasm analgesic were selected from the emergency department in our hospital from February 2016 to February 2018, . All patients were randomly divided into lidocaine group and fentanyl group, with 40 cases in each group. The VAS pain scores were recorded and compared at the time of admission and at 10,20,and 30 minutes after injection of lidocaine and fentanyl, respectively. 【Results】There was no significant difference in VAS pain scores between the two groups at the time of admission. Patients in both groups were able to relieve pain at 10,20, and 30 minutes after the injection. However, the VAS score was lower in the lidocaine group than in the fentanyl group. There was a statistical difference between the two groups (P<0.05). 【Conclusion】Both lidocaine and fentanyl are effective in relieving renal colic, but lidocaine has a faster onset, lower cost, better effect, and fewer side effects, which is worthy of clinical promotion. 2018 Vol. 35 (11): 2136-2137 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )

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