经颅直流电刺激对卒中后抑郁患者的疗效及谷氨酸、5-羟色胺表达的影响

doi:10.3969/j.issn.1671-7171.2018.11.016

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Abstract 【Objective】To investigate the effect of transcranial direct current (tDCS) stimulation on poststroke depression (PSD) and the expression of 5-hydroxytryptamine (5-HT).【Methods】From October 2016 to May 2017, 47 patients with PSD were randomly divided into observation group (n=24) and control group (n=23). The observation group was treated with true tDCS and the control group with false tDCS for 8 weeks. Before treatment and 7 days , 14 days and 8 weeks after treatment, neurologic function was assessed by the National Institutes of Health Stroke score (NIHSS), The 17-item Hamilton Depression Rating scale (HDRS) and the Montgomery Depression scale ( MADRS) were used to assess depression in patients. High performance liquid chromatography (HPLC)-fluorescence assay was used to detect plasma Glu,5-HT levels in both groups before and after treatment.【Results】Before treatment, there was no significant difference in NIHSS,HDRS,MADRS score, plasma Glu and 5-HT concentration between the two groups (P>0.05). After 8 weeks of treatment, the NIHSS,HDRS,MADRS score of the patients in the observation group decreased significantly, and the plasma 5-HT level increased, while Glu decreased. The difference was statistically significant compared with that of the control group (P<0.05).【Conclusion】 TDCS may play a better role in the treatment of PSD patients by regulating the Glu and 5-HT pathway.

Key words： Stroke/CO Electric Stimulation Therapy

Received: 11 October 2017

PACS:

R743.33

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	Articles by authors
	SU Mou-xiao
	YAO Li-ying
	CHEN Zhong-lun
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Cite this article:

SU Mou-xiao,YAO Li-ying,CHEN Zhong-lun, et al. Effect of Transcranial Direct Current (tDCS) Stimulation on Post-stroke Depression (PSD) and the Expression of 5-Hydroxytryptamine (5-HT)[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(11): 2127-2129.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2018.11.016 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2018/V35/I11/2127

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