Abstract：【Objective】 To explore the effects of rabeprazole combined with mosapride on gastric emptying rate, intestinal emptying rate, gastric motility indicators, and gastrointestinal hormones in patients with functional dyspepsia (FD).【Methods】 A total of 102 patients with FD were randomly divided into two groups: the observation group and the control group, with 51 patients in each group. Patients in the control group received only rabeprazole treatment, while the observation group was treated with rabeprazole combined with mosapride. The gastric emptying rate, intestinal emptying rate, gastric motility indicators [plasma leptin (LEP), motilin (MTL), corticotropin-releasing hormone (CRH)], and gastrointestinal hormones [gastrin (GAS), substance P (SP), vasoactive intestinal peptide (VIP)] levels were compared between the two groups before and after treatment. The incidence of adverse reactions was also recorded and compared.【Results】 After treatment, the observation group showed significantly better gastric emptying rate, intestinal emptying rate, gastric motility indicators, and gastrointestinal hormone levels compared to the control group (P<0.05). The total incidence of adverse reactions in the observation group was 5.88% (3/51), significantly lower than that of the control group at 19.61% (10/51), with a statistically significant difference (P<0.05).【Conclusion】 Rabeprazole combined with mosapride can significantly improve gastric and intestinal emptying rates, gastric motility, and gastrointestinal hormone levels in FD patients, while reducing the incidence of adverse reactions. It is worthy of clinical promotion and application.
2025, Vol. 42 
