Efficacy of Shuxuetong Injection Combined with Alteplase Thrombolysis in Treating Patients with Acute Cerebral Infarction and its Effects on IL-6, TNF-α, and MMP-9 Levels
XU Yafei, YANG Qiang
Department of Pharmacy, Tongchuan People's Hospital,Tongchuan Shaanxi 727000
Abstract：【Objective】 This study aims to explore the efficacy of Shuxuetong injection combined with alteplase thrombolysis in treating patients with acute cerebral infarction and its effects on interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinase-9 (MMP-9) levels. 【Methods】 One hundred patients with acute cerebral infarction were randomly divided into two groups, with fifty patients in each. The control group received alteplase thrombolysis alone, while the observation group received alteplase thrombolysis treatment combined with Shuxuetong injection. The efficacy, neurological function, daily living ability, hemorheological parameters before and after treatment, changes in IL-6, TNF-α, MMP-9, and C-reactive protein (CRP) levels, and the incidence of adverse reactions in both groups were compared. 【Results】 The total effective rate in the observation group was 92.00%(46/50), which was higher than 82.00%(41/50) in the control group (P<0.05). After treatment the hemorheological parameters in both groups were lower than those before treatment; And those parameters in the observation group were lower than those in the control group (P<0.05). Levels of IL-6, TNF-α, MMP-9, and CRP decreased after treatment in both groups, with even lower levels in the observation group compared to the control group (P<0.05). The National Institute of Health Stroke Scale (NIHSS) scores decreased, and Barthel Index scores increased post-treatment, with better scores in the observation group (P<0.05). No adverse reactions such as drug allergies, purpura, or bleeding occurred during the treatment in both groups. 【Conclusion】 Shuxuetong injection combined with thrombolytic therapy can effectively improve hemorheology, inhibit inflammation, and enhance vascular endothelial function in patients with acute cerebral infarction. Its efficacy is confirmed, and it is worth promoting in clinical applications.
徐亚菲, 杨强. 疏血通注射液联合阿替普酶溶栓治疗急性脑梗死患者的疗效及对IL-6、TNF-α、MMP-9水平的影响[J]. 医学临床研究, 2024, 41(8): 1195-1197.
XU Yafei, YANG Qiang. Efficacy of Shuxuetong Injection Combined with Alteplase Thrombolysis in Treating Patients with Acute Cerebral Infarction and its Effects on IL-6, TNF-α, and MMP-9 Levels. JOURNAL OF CLINICAL RESEARCH, 2024, 41(8): 1195-1197.
2024, Vol. 41 
