Effect of Prednisone and Cyclosporine A on Pregnancy Outcome, Serum Sex Hormone and Immune Function in Treatment of Patients with Recurrent Spontaneous Abortion
WU Hong, LI Honghua
Department of Obstetrics and Gynecology, Jiangning District Maternal and Child Health and Family Planning Service Center, Nanjing Jiangsu 211100
Abstract：【Objective】To investigate the efficacy of prednisone and cyclosporine A in the treatment of recurrent spontaneous abortion (RSA) and the effects on pregnancy outcomes, serum sex hormones and immune function. 【Methods】A total of 102 RSA patients diagnosed and treated in two hospitals from January 2021 to January 2023 were randomly divided into the observation group [treated with prednisone + cyclosporin A+ progesterone + human chorionic gonadotropin (HCG) + Philovidian] and the control group (progesterone +HCG+ philovidian), with 51 cases in each group. Serum levels of estradiol (E2), progesterone (P), luteinizing hormone (LH), CD3+, CD4+, CD8+, CD4+/CD8+ were detected before and after treatment in both groups. The rate of re-abortion, full-term pregnancy, successful preterm delivery, successful delivery and complications were compared between the two groups.【Results】After treatment, E2, P and LH levels in both control and observation groups were higher than those before treatment, and levels of E2, P and LH in the observation group was higher than those in the control group, the differences were statistically significant (P<0.05). After treatment, CD3+, CD4+ and CD4+/CD8+ in both groups significantly increased, while CD8+ level significantly decreased compared with those before treatment; And CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, while CD8+ was lower than that in the control group, with statistical significance (P<0.05). The rate of repeated abortion in the observation group was lower than that in the control group, and the full-term pregnancy and successful delivery rates were higher than those in control group (P<0.05). The total incidence of complications in the observation group was 11.76%, compared with 7.84% in the control group, there was no significant difference (P>0.05). 【Conclusion】Prednisone and cyclosporin A can effectively regulate sex hormone levels and immune function in RSA patients, improve pregnancy outcomes, and have certain safety.
吴虹, 李红花. 泼尼松、环孢素A治疗反复自然流产患者的疗效及对患者妊娠结局、血清性激素水平和免疫功能的影响[J]. 医学临床研究, 2025, 42(3): 453-455.
WU Hong, LI Honghua. Effect of Prednisone and Cyclosporine A on Pregnancy Outcome, Serum Sex Hormone and Immune Function in Treatment of Patients with Recurrent Spontaneous Abortion. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 453-455.
[1] 张清华,潘静,姚丽艳.复发性流产患者病因构成分析[J].中国全科医学,2020,23(14):1760-1764. [2] 王东霞,武艳琪,刘俊杰.早期复发性流产患者病因及流产胚胎染色体异常分析[J].中国计划生育学杂志,2020,28(3):404. [3] 韩继荣,武琳琳,张喻.孕康颗粒联合黄体酮治疗反复性流产的临床疗效[J].医学临床研究,2024,41(5):786-788. [4] HUANG W, LU W Y, LI Q, et al. Effects of cyclosporine A on proliferation, invasion and migration of HTR-8/SVneo human extravillous trophoblasts[J].Biochem Biophys Res Commun,2020,533(4):645-650. [5] 谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:12-13. [6] 张丽梅,杨燕宁,张瑞晓,等.自然流产两次与三次及以上的早期复发性流产患者病因构成的比较[J].中华妇产科杂志,2018,53(12):855-859. [7] 高景波,郭慧敏,朱镭,等.高龄反复自然流产患者封闭抗体和淋巴细胞亚群分析[J].中国综合临床,2020,36(4):376-379. [8] 彭军,陈娟,童冠英,等.DROSHA基因多态性及TORCH感染与育龄女性复发性自然流产的关联[J].中华医院感染学杂志,2022,32(13):2053-2057. [9] 李晖,许常娟,宁艳辉,等.暖宫消抗汤对封闭抗体缺乏型反复自然流产肾脾两虚证免疫调节作用的临床研究[J].中国临床医生杂志,2018,46(11):1376-1378. [10] 肖育红,马向薇.黄体酮联合主动免疫对同种免疫型复发性流产患者免疫调节失衡影响[J].临床军医杂志,2021,15(3):327. [11] 高颖,郑娇妮.主动免疫治疗复发性流产的临床观察[J].中国妇幼保健,2018,33(5):1127-1128. [12] 马敏,姚淑艳,李玉敏.低分子肝素联合环孢素A治疗不明原因复发性流产效果及对免疫平衡、血液流变学影响[J].中国计划生育学杂志,2023,31(1):153-158. [13] 敖明珠,于海华.阿司匹林联合泼尼松治疗复发性流产效果及对患者免疫平衡及妊娠结局影响[J].中国计划生育学杂志,2023,31(3):575-580.
2025, Vol. 42 
