Abstract：【Objective】To investigate the clinical efficacy of phased radiofrequency microneedling combined with minocycline in the treatment of moderate to severe acne. 【Methods】Sixty patients with moderate to severe acne who visited our clinic from July 2022 to December 2023 were randomly divided into the observation group (treated with phased radiofrequency microneedle combined with minocycline) and the control group (treated with intense pulsed light combined with minocycline) using a random number table method, with 30 patients in each group. The observation group was treated with phase controlled radiofrequency microneedle combined with minocycline, while the control group was treated with intense pulsed light combined with minocycline. Both groups received single treatment. We compared the scores of the Global Acne Grading System (GAGS) and the conditions of erythema, pores, and amethyst between two groups before treatment, 1 month after treatment, and 3 months after treatment. We also compared the treatment efficacy and incidence of adverse reactions between the two groups.【Results】One month after treatment, the effective rate of the observation group was 93.33%, which was not significantly different from the control group's 86.67% (P>0.05). After treatment, the GAGS scores of both groups decreased compared to before treatment, and the GAGS score of the observation group was lower than that of the control group (P<0.05). After treatment, both groups showed significant improvement in erythema, purple pigment, and pores compared to before treatment (P<0.05); And the improvement of erythema and pores in the observation group was better than that in the control group (P<0.05), but there was no statistically significant difference in the percentage of purple matter between the two groups (P>0.05). All patients had no significant adverse reactions. 【Conclusion】The combination of phase controlled radiofrequency microneedles or intense pulsed light with minocycline is safe and effective in treating moderate to severe acne vulgaris. However, the combination of phase controlled radiofrequency microneedles and minocycline has a more significant improvement in enlarged pores and fine skin texture.
郭敏, 高明, 李文璐. 相控射频微针联合米诺环素治疗中重度痤疮的临床疗效[J]. 医学临床研究, 2024, 41(8): 1152-1155.
GUO Min, GAO Ming, LI Wenlu. Clinical Efficacy of Phase Controlled Radiofrequency Microneedle Combined with Minocycline for the Treatment of Moderate to Severe Acne. JOURNAL OF CLINICAL RESEARCH, 2024, 41(8): 1152-1155.
[1] KIM C N T, THI L P, VAN T N, et al. Successful treatment of facial atrophic acne scars by fractional radiofrequency microneedle in vietnamese patients[J].Open Access Maced J Med Sci,2019, 7(2): 192-194. [2] 鞠强.中国痤疮治疗指南(2019修订版)[J].临床皮肤科杂志,2019,48(9):583-588. [3] 赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2010:289. [4] DOSHI A, ZAHEER A, STILLER M J.A comparison of current acne grading systems and proposal of a novel system[J].Int J Dermatol,1997,36(6):416-418. [5] HAZARIKA N.Acne vulgaris:new evidence in pathogene- sis and future modalities of treatment[J].J Dermatolog Treat,2021,32(3):277-285. [6] SIRITHANABADEEKUL P,LEETRAKULWANNA V,SUWANCHINDA A.A novel technique in reducing sebum production and improving atrophic acne scars[J].J Cosmet Dermatol,2022,21: 5872-5879. [7] ZENG R, LIU Y Z, ZHAO W W, et al. A splitface comparison of a fractional microneedle radiofrequency device and fractional radiofrequency therapy for moderate-to-severe acne vulgaris[J].J Cosmet Dermatol,2020, 19(10): 2566-2571. [8] KAMINAKA C,UEDE M,NAKAMURA Y ,et al. Histological studies of facial acne and atrophic acne scars treated with a bipolar fractional radiofrequency system[J].J Dermatol,2014, 41(5): 435-438. [9] 张凡旋.红蓝光治疗仪结合微针射频痤疮治疗仪治疗痤疮、毛孔的临床疗效研究[J].中国医疗器械信息,2024,30(2):58-60. [10] 刘扬声,郑蕾,曾强.异维A酸胶囊联合微针射频等离子治疗中重度痤疮疗效观察[J].中国美容医学,2023,32(8):88-91. [11] 朱学娥,向芳,段曼曼,等.微针射频与强脉冲激光治疗痤疮后红斑的疗效比较[J].中国激光医学杂志,2023,32(1):48-50. [12] 马晓红,张亚勤.异维A酸胶囊间歇疗法联合克林霉素甲硝唑治疗中重度痤疮的临床疗效[J].医学临床研究,2023,40(8):1157-1160.
2024, Vol. 41 
