医学临床研究
  2025年7月6日 星期日           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2024, Vol. 41 Issue (9): 1354-1357    DOI: 10.3969/j.issn.1671-7171.2024.09.020
  论著 本期目录 | 过刊浏览 | 高级检索 |
布地格福吸入气雾剂治疗急性加重高风险慢性阻塞性肺疾病患者的疗效
朱艳竞, 陈培杰, 纪小丽, 朱利芹*
上海市静安区中心医院呼吸与危重症医学科,上海 200040
Efficacy of Budesonide-Formoterol Inhalation Aerosol in Treating High-Risk Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients
ZHU Yanjing, CHEN Peijie, JI Xiaoli, et al
Department of Respiratory and Critical Care Medicine, Jing'an District Central Hospital, Shanghai 200040
全文: PDF (1210 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)       背景资料
摘要 【目的】探讨布地格福吸入气雾剂治疗急性加重高风险慢性阻塞性肺疾病(COPD)的疗效及其安全性。 【方法】160 例急性加重高风险 COPD 患者,随机分为观察组(布地格福吸入气雾剂治疗)和对照组(茚达特罗格隆溴铵吸入粉雾剂用胶囊治疗),每组80例。比较两组患者治疗前及治疗后3个月、6个月的肺功能指标、血气指标、COPD评估测试(CAT)评分、呼吸困难指数(mMRC)评分、运动耐力[6 min步行距离(6MWD)]、生命质量(SGRQ)评分。【结果】治疗3个月、6个月后,观察组患者的肺功能指标、血气指标明显优于对照组(P<0.05);观察组的mMRC评分、CAT评分以及SGRQ量表中的呼吸症状评分低于对照组(P<0.05),6MWD大于对照组(P<0.05),而两组SGRQ量表中的日常活动、疾病症状评分及总分比较,差异无统计学意义(P>0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。 【结论】布地格福吸入气雾剂治疗急性加重高风险COPD患者的疗效好,且不增加药物不良反应的发生率。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
朱艳竞
陈培杰
纪小丽
朱利芹
关键词 肺疾病,慢性阻塞性/药物疗法支气管扩张药/药理学治疗结果    
Abstract:【Objective】To investigate the efficacy and safety of Budesonide-Formoterol inhalation aerosol in treating high-risk acute exacerbations of chronic obstructive pulmonary disease (COPD).【Methods】A total of 160 patients with high-risk acute exacerbations of COPD were randomly divided into the observation group (treated with Budesonide-Formoterol inhalation aerosol) and the control group (treated with Indacaterol-Glycopyrronium inhalation powder capsules), with 80 cases in each group. The differences in pulmonary function indicators, blood gas indicators, COPD assessment test (CAT) scores, modified Medical Research Council (mMRC) dyspnea scale scores, exercise endurance [six-minute walk distance (6MWD)] and quality of life (SGRQ) scores before treatment, and at 3 months and 6 months after treatment were compared between the two groups.【Results】 After 3 and 6 months of treatment, the pulmonary function indicators and blood gas indicators of the observation group were significantly better than those of the control group (P<0.05). The mMRC, CAT, and respiratory symptom scores in the SGRQ scale of the observation group were lower than those of the control group (P<0.05), and the 6MWD was higher than that of the control group (P<0.05). However, there was no statistically significant difference in daily activities, disease symptoms, and total scores on the SGRQ scale between the two groups (P>0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 Budesonide-Formoterol inhalation aerosol is effective in treating high-risk acute exacerbations of COPD and it does not increase the incidence of adverse drug reactions.
Key wordsPulmonary Disease, Chronic Obstructive/DT    Bronchodilator Agents/PD    Treatment Outcome
收稿日期: 2023-12-20     
中图分类号:  R563  
通讯作者: * E-mail:zzm95752829@163.com   
引用本文:   
朱艳竞, 陈培杰, 纪小丽, 朱利芹. 布地格福吸入气雾剂治疗急性加重高风险慢性阻塞性肺疾病患者的疗效[J]. 医学临床研究, 2024, 41(9): 1354-1357.
ZHU Yanjing, CHEN Peijie, JI Xiaoli, et al. Efficacy of Budesonide-Formoterol Inhalation Aerosol in Treating High-Risk Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(9): 1354-1357.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.09.020     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I9/1354
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn