TLR4与NSE水平对热性惊厥患儿的诊断价值

doi:10.3969/j.issn.1671-7171.2025.03.023

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摘要【目的】探讨Toll样受体4(TLR4)和神经元特异性烯醇化酶(NSE)对热性惊厥患儿的诊断价值。【方法】本院收治的72例热性惊厥儿童作为C组,86例感染发热无惊厥儿童作为B组,同期体检健康儿童83例作为A组。检测各组TLR4和NSE的表达水平;采用Spearman相关性分析TLR4和NSE表达水平与患儿热性惊厥的相关性,并采用受试者工作特征(ROC)曲线分析TLR4和NSE对儿童热性惊厥中的诊断效能。【结果】B组和C组患儿TLR4和NSE水平均高于A组(P<0.05),且C组高于B组(P<0.05)。TLR4和NSE水平与患儿热性惊厥均呈正相关(P<0.05)。TLR4和NSE单独及联合检测的敏感度分别为86.1%、79.2%、80.6%;特异度分别为55.8%、74.4%、88.4%;曲线下面积(AUC)分别为0.742、0.832、0.911,两者联合检测价值优于单独检测(P<0.05)。【结论】TLR4和NSE水平升高与热性惊厥密切相关,且两者联合检测可提高热性惊厥的诊断效能,具有重要的临床意义。

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	丁金金
	赵彩红
	刘友红

关键词 ：惊厥,发热性, Toll样受体4, 磷酸丙酮酸水合酶, 诊断

Abstract：【Objective】 To explore the diagnostic value of Toll-like receptor 4 (TLR4) and neuron-specific enolase (NSE) levels in children with febrile seizures.【Methods】 A total of 72 children with febrile seizures were included in group C, 86 children with fever and infection but no seizures in group B, and 83 healthy children during physical exams in group A. The levels of TLR4 and NSE were measured in all groups. Spearman correlation analysis was used to assess the correlation of febrile seizures with levels of TLR4 and NSE . The diagnostic efficacy of TLR4 and NSE in febrile seizures was analyzed using receiver operating characteristic (ROC) curves.【Results】 The TLR4 and NSE levels in group B and group C were significantly higher than that in group A (P<0.05), with group C showing higher level than group B (P<0.05). Both TLR4 and NSE levels were positively correlated with febrile seizures (P<0.05). The sensitivity of TLR4 and NSE alone and combined detection was 86.1%, 79.2%, and 80.6%, respectively; their specificities were 55.8%, 74.4%, and 88.4%, respectively. And the area under the curve (AUC) was 0.742, 0.832, and 0.911, respectively. Combined detection had better diagnostic value than individual detection (P<0.05).【Conclusion】 Elevated TLR4 and NSE levels in children with febrile seizures are closely associated with the severity. Combined detection of TLR4 and NSE can improve the diagnostic efficiency of febrile seizures and has important clinical significance.

Key words： Seizures, Febrile Toll-Like Receptor 4 Phosphopyruvate Hydratase Diagnosis

收稿日期: 2024-12-10

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R725

引用本文:

丁金金, 赵彩红, 刘友红. TLR4与NSE水平对热性惊厥患儿的诊断价值[J]. 医学临床研究, 2025, 42(3): 447-449.
DING Jinjin, ZHAO Caihong, LIU Youhong. Diagnostic Value of TLR4 and NSE Levels in Children with Febrile Seizures. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 447-449.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.03.023 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I3/447

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