Abstract：【Objective】To explore the relationship of prognosis with C-reactive protein (CRP), lactate dehydrogenase (LDH), and β2-microglobulin (β2-MG) levels in multiple myeloma (MM) patients.【Methods】A retrospective analysis was conducted on the clinical data of 96 MM patients, including age, gender, International Staging System (ISS) stage, immunoglobulin subtype, comorbidities, coagulation markers, lipid profiles, homocysteine (Hcy) levels, and CRP, LDH, and β2-MG levels. Factors influencing prognosis were analyzed, and Spearman's correlation test was used to analyze the correlation of prognosis with levels of Hcy, CRP, LDH and β2-MG.【Results】Among the 96 patients, 79 (82.29%) were alive and were categorized into the survival group, while 17 (17.71%) died and were categorized into the death group. The proportion of ISS stage Ⅱ and Ⅲ, as well as CRP, LDH, β2-MG, and Hcy levels in the death group, were significantly higher than those in the survival group (P<0.05). CRP, LDH, β2-MG, and Hcy were found to be significant prognostic factors for MM (P<0.05). Spearman's test showed that Hcy, CRP, LDH, and β2-MG levels were positively correlated with prognosis (P<0.05).【Conclusion】As the levels of Hcy, CRP, LDH, and β2-MG increase, the severity of the disease worsens, and the risk of poor prognosis in MM patients rises.
郭晓丹, 易善永, 李艳艳, 邢国臣. 多发性骨髓瘤患者CRP、LDH及β2-MG水平与预后的相关性[J]. 医学临床研究, 2025, 42(2): 258-260.
GUO Xiaodan, YI Shanyong, LI Yanyan, et al. Correlation of CRP, LDH, and β2-MG Levels with Prognosis in Multiple Myeloma Patients. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 258-260.
2025, Vol. 42 
