Abstract：【Objective】To investigate the clinical pathological characteristics and prognostic impact of patients with primary TP53 mutated gastric cancer.【Methods】This retrospective study analyzed the clinical data of 68 patients with TP53 mutated gastric cancer (mutation group) and 102 patients with TP53 wild-type gastric cancer (wild-type group). The clinical pathological characteristics of the two groups were compared. Survival curves were plotted using the Kaplan-Meier method, and overall survival (OS) and disease-free survival (DFS) were compared using the Log-rank test. Univariate analysis and Cox regression models were employed to explore the independent factors affecting the prognosis of gastric cancer patients.【Results】Patients in the mutation group with age≥55 a significantly higher proportion of poorly differentiated tumors, advanced (Stage Ⅲ+Ⅳ) TNM staging, lymph node metastasis, and larger tumor size compared to the wild-type group (P<0.05). Survival analysis showed that the 3-year OS and DFS rates of the TP53 mutation group were significantly lower than those of the wild-type group (P<0.05). Univariate Cox regression analysis indicated that differentiation degree, TNM stage, lymph node metastasis, tumor diameter, and TP53 mutation were adverse prognostic factors for gastric cancer; multivariate Cox regression analysis revealed that age, differentiation degree, TNM stage, lymph node metastasis, tumor diameter, and TP53 mutation were independent risk factors for poor prognosis in gastric cancer.【Conclusion】Patients with TP53 mutated gastric cancer exhibit poorer clinical characteristics and prognosis. Age, differentiation degree, TNM stage, lymph node metastasis, tumor diameter, and TP53 mutation are independent prognostic risk factors.
2025, Vol. 42 
