Abstract：【Objective】To investigate the clinical value of dual-source CT whole brain perfusion imaging (CTP) in predicting the prognosis of patients with acute ischemic stroke (AIS).【Methods】A total of 100 patients with AIS admitted to our hospital were divided into poor prognosis group (mRS scores>2 points, n=31) and good prognosis group (mRS scores≤2 points, n=69) according to mRS Scores on the 90th day after discharge. Baseline mRS and National Institutes of Health Stroke Scale (NIHSS) scores of all patients were compared. Cerebral blood volume (CBV), time to peak (TTP), mean transit time (MTT), and time of delay(TD) were calculated by dual-source CTP. The correlation of baseline NIHSS score and mRS Score with CBV, TTP, MTT and TD was discussed, and the influence of these parameters on the 90d prognosis of AIS patients was analyzed.【Results】There was no statistical significance in the basic clinical data between the good prognosis group and the poor prognosis group (P>0.05).Compared with the good prognosis group, CBV was decreased in the poor prognosis group, but TTP, MTT and DLT were increased (P<0.05). Pearson correlation analysis showed that mRS and NIHSS scores were negatively correlated with CBV and positively correlated with TTP, MTT and TD, respectively (P<0.05).Multivariate Logistic regression showed that CBV was an independent protective factor affecting the prognosis of AIS patients within 90 days, and TTP was an independent risk factor affecting the prognosis of AIS patients within 90 days (P<0.05).【Conclusion】Dual-source CTP related parameters are potential prognostic factors in AIS patients within 90 days, in which CBV is a protective factor affecting prognosis, while TTP is a risk factor affecting prognosis. CBV, TTP, MTT and TD are significantly correlated with baseline mRS And NIHSS scores. Helps to identify high-risk patients early and guide personalized treatment.
2025, Vol. 42 
