多发性骨髓瘤患者CRP、LDH及β<sub>2</sub>-MG水平与预后的相关性

doi:10.3969/j.issn.1671-7171.2025.02.024

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摘要【目的】探讨多发性骨髓瘤(MM)患者C反应蛋白(CRP)、乳酸脱氢酶(LDH)及β₂-微球蛋白(β₂-MG)水平与预后的关系。【方法】对96例MM患者的临床资料行回顾性分析,统计患者年龄、性别、国际分期(ISS)、免疫球蛋白分型、合并疾病、凝血指标、血脂指标、同型半胱氨酸(Hcy)及CRP、LDH、β₂-MG水平等相关资料,分析影响MM患者预后的相关因素,采用Spearman检验分析患者Hcy、CRP、LDH及β₂-MG与预后的相关性。【结果】96例患者中,有79例(82.29%)患者存活,纳为存活组;有17例(17.71%)患者死亡,纳为死亡组。死亡组ISS分期为Ⅱ、Ⅲ期所占比例及CRP、LDH、β₂-MG、Hcy水平均高于存活组(P<0.05)。CRP、LDH、β₂-MG、Hcy水平是MM患者预后的影响因素(P<0.05)。Spearman检验显示,MM患者的Hcy、CRP、LDH及β₂-MG水平与预后呈正相关(P<0.05)。【结论】随着Hcy、CRP、LDH及β₂-MG水平升高,患者病情加重,其预后不良的风险发生率提升。

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	郭晓丹
	易善永
	李艳艳
	邢国臣

关键词 ：多发性骨髓瘤, C反应蛋白质, L-乳酸脱氢酶, β₂微球蛋白, 预后

Abstract：【Objective】To explore the relationship of prognosis with C-reactive protein (CRP), lactate dehydrogenase (LDH), and β₂-microglobulin (β₂-MG) levels in multiple myeloma (MM) patients.【Methods】A retrospective analysis was conducted on the clinical data of 96 MM patients, including age, gender, International Staging System (ISS) stage, immunoglobulin subtype, comorbidities, coagulation markers, lipid profiles, homocysteine (Hcy) levels, and CRP, LDH, and β₂-MG levels. Factors influencing prognosis were analyzed, and Spearman's correlation test was used to analyze the correlation of prognosis with levels of Hcy, CRP, LDH and β₂-MG.【Results】Among the 96 patients, 79 (82.29%) were alive and were categorized into the survival group, while 17 (17.71%) died and were categorized into the death group. The proportion of ISS stage Ⅱ and Ⅲ, as well as CRP, LDH, β₂-MG, and Hcy levels in the death group, were significantly higher than those in the survival group (P<0.05). CRP, LDH, β₂-MG, and Hcy were found to be significant prognostic factors for MM (P<0.05). Spearman's test showed that Hcy, CRP, LDH, and β₂-MG levels were positively correlated with prognosis (P<0.05).【Conclusion】As the levels of Hcy, CRP, LDH, and β₂-MG increase, the severity of the disease worsens, and the risk of poor prognosis in MM patients rises.

Key words： Multiple Myeloma C-Reactive Protein L-Lactate Dehydrogenase beta 2-Microglobulin Prognosis

收稿日期: 2023-01-12

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R733.3

通讯作者: *E-mail:yisy2001@163.com

引用本文:

郭晓丹, 易善永, 李艳艳, 邢国臣. 多发性骨髓瘤患者CRP、LDH及β₂-MG水平与预后的相关性[J]. 医学临床研究, 2025, 42(2): 258-260.
GUO Xiaodan, YI Shanyong, LI Yanyan, et al. Correlation of CRP, LDH, and β₂-MG Levels with Prognosis in Multiple Myeloma Patients. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 258-260.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.02.024 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I2/258