维生素B<sub>12</sub>和叶酸治疗巨幼细胞贫血患者的临床疗效

doi:10.3969/j.issn.1671-7171.2025.02.023

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摘要【目的】探讨维生素B₁₂和叶酸治疗巨幼细胞贫血(MA)患者的临床疗效。【方法】收集50例采用维生素B₁₂和叶酸补充治疗的MA患者的临床资料,分析患者的临床表现,血液学指标的变化和治疗效果。【结果】治疗后,患者的平均红细胞体积(MCV)较治疗前降低,血红蛋白(Hb)、维生素B₁₂、叶酸水平较治疗前升高,且差异均有统计学意义(P<0.05)。治疗后,乏力、面色苍白、食欲不振、体重下降、有神经症状的患者的比例较治疗前明显降低,差异有统计学意义(P<0.05)。相关性分析显示,维生素B₁₂与症状改善的关联最为密切,维生素B₁₂、叶酸、Hb水平与乏力、面色苍白、食欲不振、体重下降、神经症状均呈负相关(P<0.05)。MCV与上述症状均呈正相关(P<0.05)。【结论】维生素B₁₂和叶酸的补充治疗可以改善MA患者的血液学指标和临床症状,其中,维生素B₁₂在症状改善中发挥了关键作用,临床在诊治MA时,应重视维生素B₁₂水平的检测和补充。

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	孙兴卫

关键词 ：贫血, 巨幼细胞性, 维生素B₁₂, 叶酸, 治疗结果

Abstract：【Objective】To explore the clinical efficacy of vitamin B₁₂ and folic acid in the treatment of megaloblastic anemia (MA) patients.【Methods】Clinical data of 50 MA patients treated with vitamin B₁₂ and folic acid supplementation were collected. The patients' clinical manifestations, changes in hematological indicators, and treatment outcomes were analyzed.【Results】After treatment, the mean corpuscular volume (MCV) of the patients decreased, while hemoglobin (Hb), vitamin B₁₂, and folic acid levels increased significantly compared to before treatment, with differences being statistically significant (P<0.05). The proportion of patients with symptoms such as fatigue, pallor, loss of appetite, weight loss, and neurological symptoms significantly decreased after treatment, with differences being statistically significant (P<0.05). Correlation analysis showed that vitamin B₁₂ had the closest association with symptom improvement. Vitamin B₁₂, folic acid, and Hb levels were negatively correlated with fatigue, pallor, loss of appetite, weight loss, and neurological symptoms (all P<0.05). MCV was positively correlated with the above symptoms (P<0.05).【Conclusion】Supplementation of vitamin B₁₂ and folic acid can improve hematological indicators and clinical symptoms in MA patients, which vitamin B₁₂ plays a key role in symptom improvement. When diagnosing and treating MA clinically, attention should be paid to the detection and supplementation of vitamin B₁₂ levels.

Key words： Anemia, Megaloblastic Vitamin B₁₂ Folic Acid Treatment Outcome

收稿日期: 2024-11-02

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R556

引用本文:

孙兴卫. 维生素B₁₂和叶酸治疗巨幼细胞贫血患者的临床疗效[J]. 医学临床研究, 2025, 42(2): 255-257.
SUN Xingwei. Clinical Efficacy of Vitamin B₁₂ and Folic Acid in the Treatment of Megaloblastic Anemia Patients. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 255-257.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.02.023 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I2/255

[1] TORREZ M, CHABOT‐RICHARDS D, BABU D, et al. How I investigate acquired megaloblastic anemia[J].Int J Lab Hematol,2022, 44(2): 236-247.
[2] 全红.巨幼细胞性贫血患者血清叶酸、维生素B₁₂水平和骨髓细胞形态学检测及疾病严重程度的相关性[J].吉林医学,2023,44(12):3430-3433.
[3] DUTTA T K. Megaloblastic anemia[J].Ann Clin Med Case Rep,2023, 10(15): 1-5.
[4] 周剑峰,孙汉英,张义成.血液病诊疗指南[M].北京:科学出版社,2013:48-50.
[5] TANG L, MIAO J, WANG J B. Clinical characteristics of megaloblastic anemia with pancytopenia[J].Hematology,2024, 29(1): 2420407.
[6] YAN X, KONG J X, WANG J C, et al. Severe megaloblastic anemia in a patient with advanced lung adenocarcinoma during treatment with erlotinib: a case report and literature review[J].BMC Pulm Med,2024, 24(1): 121.
[7] SAHOO S, SAHU N, DAS P, et al. Effect of megaloblastic anemia on hemoglobin A2 and diagnosis of β-thalassemia trait[J].Indian J Pathol Microbiol,2023, 66(2): 327-331.
[8] SOCHA D S, DESOUZA S I, FLAGG A,et al.Severe megaloblastic anemia: Vitamin deficiency and other causes[J].Cleve Clin J Med,2020,87(3):153-164.
[9] OPREA V D, BOJINCĂ V C, BĂLĂNESCU A R, et al. Paget's disease of bone and megaloblastic anemia in a 72 year old patient: A case report and systematic literature review[J].Exp Ther Med,2022, 23(4): 269.
[10] 朱永超,丁勇,李凯.慢性萎缩性胃炎患者血清维生素B₁₂水平与周围神经病变的相关性分析[J].医学临床研究,2020,37(12):1886-1888.
[11] 黄璐,赵莉,尤金枝.甲钴胺对结直肠癌患者XELOX方案引起的外周神经病变的影响[J].医学临床研究,2022,39(12):1827-1829.
[12] ZHAO Y F, HUANG T T, WANG X, et al. Measurement for the area of red blood cells from microscopic images based on image processing technology and its applications in aplastic anemia, megaloblastic anemia, and myelodysplastic syndrome[J].Front Med(Lausanne),2022, 8: 796920.
[13] QI J, LI Y, DUAN L, et al. Analysis of cognitive dysfunction and its influencing factors in patients with megaloblastic anemia[J].Clin Med,2024, 5(3): 68-74.