Effect of Nicodil on Cardiac Function and Renal Function in Patients with Acute ST Segment Elevation Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervention
ZHANG Dawei, CHEN Rong
Department of Cardiology, Zhenjiang First People's Hospital, Zhenjiang Jiangsu 212002
Abstract：【Objective】To investigate the effects of nicodil on cardiac function and renal function in patients with acute ST elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). 【Methods】The clinical data of 160 patients with acute STEMI who underwent emergency PCI in Zhenjiang First People's Hospital from November 2020 to August 2022 were retrospectively analyzed, and they were divided into observation group (conventional treatment + nicodil, n=89) and control group (conventional treatment, n=71) according to treatment methods. ST segment regression, echocardiographic parameters [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDD), left ventricular end-systolic diameter (LVDS)] and renal function indicators (serum creatinine, urea nitrogen, uric acid) were compared between the two groups. 【Results】The proportion of ST segment regression rate ≥ 50% in the control group 2 h after PCI was lower than that in the observation group, and the difference was statistically significant (P<0.05). At 1 week and 1 month after surgery, LVDD and LVEF in 2 groups were higher than 1 day after surgery, the difference was statistically significant (P<0.05), while LVDS in 2 groups was not statistically significant compared with 1 day after surgery (P>0.05). There was no significant difference in LVDD, LVEF and LVDS between the observation group at 1 week and 1 month after surgery (P>0.05). The level of urea nitrogen 2 days after operation was lower than that before operation, the difference was statistically significant (P<0.05), but there was no statistically significant difference in serum creatinine and uric acid levels between the observation group and before operation (P>0.05).There were no significant differences in the levels of urea nitrogen, creatinine and uric acid in patients with anterior infarction in the observation group (P>0.05). The levels of urea nitrogen and uric acid 2 days after operation in patients with inferior infarction were lower than those before operation, and the differences were statistically significant (P<0.05). There were significant differences in the levels of creatinine and uric acid in patients with anterior infarction in the control group (P<0.05). The levels of urea nitrogen 2 days after operation in patients with inferior infarction were lower than those before operation, and the differences were statistically significant (P<0.05). 【Conclusion】Nicodil can improve myocardial perfusion level and protect renal function in acute STEMI patients after emergency PCI, especially in patients with anterior infarction.
张大伟, 陈蓉. 尼可地尔对行急诊冠状动脉介入治疗的急性ST段抬高型心肌梗死患者心功能、肾功能的影响[J]. 医学临床研究, 2025, 42(1): 64-67.
ZHANG Dawei, CHEN Rong. Effect of Nicodil on Cardiac Function and Renal Function in Patients with Acute ST Segment Elevation Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervention. JOURNAL OF CLINICAL RESEARCH, 2025, 42(1): 64-67.
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2025, Vol. 42 
