Abstract：【Objective】To investigate the relationship of serum amino-terminal precursor B-type brain natriuretic peptide (NT-proBNP) and uric acid (UA)/creatinine (Cr) with the severity of coronary heart disease in patients with unstable angina pectoris (UAP),and evaluate the predictive value of acute myocardial infarction (AMI) morbidity with NT-proBNP combined Cr measurement. 【Methods】A total of 127 UAP patients admitted to the hospital were selected as the research objects. The serum NT-proBNP and UA/Cr of patients with different severity of UAP were compared. Follow-up for 1 month,the occurrence of AMI in UAP patients was counted. Patients were divided into the occurrence group (23 cases) and the non-incident group (104 cases) according to whether AMI occurred or not. The clinical data of the patients in the occurrence group and the non-occurrence group were compared. Logistic multivariate regression was used to analyze the risk factors for AMI in UAP patients. The area under the curve (AUC) of receiver operating characteristic curve (ROC) was drawn to evaluate the predictive performance of serum NT-proBNP and UA/Cr on the occurrence of AMI in UAP patients. 【Results】Serum NT-proBNP and UA/Cr of UAP patients in the severe group were higher than those in the mild and moderate groups (P<0.05). The serum NT-proBNP and UA/Cr of UAP patients in the moderate group were higher than those in the mild group (P<0.05). The proportion of severe coronary heart disease,cardiac troponin I (cTnI),homocysteine,UA,serum NT-proBNP and UA/Cr in the AMI occurrence group were higher than those in the AMI non-occurrence group (P<0.05),while the left ventricular ejection fraction (LVEF) was lower in the non-occurrence group (P<0.05). Multivariate analysis showed that the disease was the disease severity,LVEF,cTnI ,NT-proBNP and UA/Cr were all risk factors for the occurrence of AMI in UAP patients (P<0.05). The results of ROC curve analysis showed that the sensitivity of serum NT-proBNP,UA/Cr alone and their combined detection to predict the occurrence of AMI in UAP patients was 69.57%,73.91% and 79.52%,respectively; And the specificity was 79.81%,74.04% and 98.08%,respectively. The AUC were 0.721,0.770 and 0.901,respectively. 【Conclusion】The serum NT-proBNP and UA/Cr of UAP patients are related to the severity of coronary heart disease and the incidence of AMI. The combination of NT-proBNP and UA/Cr of UAP detection has a higher predictive performance for the incidence of AMI in UAP patients.
吴晶晶, 陈润祥, 廖占玲, 安国印, 郭洁. 血清NT-proBNP、UA/Cr联合检测对UAP患者发生AMI的预测价值[J]. 医学临床研究, 2023, 40(2): 241-244.
WU Jing-jing, CHEN Run-xiang, LIAO Zhan-ling,et al. Application of the Combination of Serum NT-proBNP and UA/Cr in Predicting the Incidence of AMI in UAP Patients. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 241-244.
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