Abstract：【Objective】 To investigate the correlation between serum high mobility group B1 (HMGB1), D-dimer (D-D) levels and prognosis in patients with acute traumatic coagulopathy (ATC). 【Methods】 A total of 86 ATC patients (observation group) hospitalized in our hospital from July 2019 to May 2020 were selected and divided into survival group and death group according to the prognosis of ATC patients during hospitalization; In addition, 74 healthy volunteers who were examined in our hospital at the same time were selected as the control group. The serum HMGB1 level was detected by ELISA; Serum D-D and hs-CRP levels were detected by immunoturbidimetry; Prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet count (PLT) were measured by automatic blood coagulation analyzer; The correlation between the levels of HMGB1 and D-D and the indexes of coagulation function and inflammation in patients with ATC was analyzed; The prognostic factors of ATC patients were also analyzed. 【Results】 HMGB1, D-D, PT, APTT, hs-CRP in the observation group were higher than those in the control group, while PLT was lower than that in the control group, with statistical significance (P<0.05); HMGB1 was positively correlated with D-D levels in ATC patients (r=0.594, P<0.05), and positively correlated with PT, APTT, hs-CRP (P<0.05), and negatively correlated with PLT (P<0.05). HMGB1, D-D, PT, APTT, hs-CRP in the death group were higher than those in the survival group, while PLT was lower than those in the survival group, with significant difference (P<0.05); HMGB1 and D-D were independent risk factors for death of ATC patients (P<0.05), and PLT was protective factor for death of ATC patients (P<0.05). 【Conclusion】 The levels of HMGB1 and D-D in patients with ATC are elevated, which has certain significance in predicting the prognosis of patients.
李钰. 急性创伤性凝血病患者血清高迁移率族蛋白B1、D-二聚体水平与预后的相关性分析[J]. 医学临床研究, 2023, 40(1): 78-80.
LI Yu. Correlation between Serum High Mobility Group Protein B1, D-dimer Levels and Prognosis in Patients with Acute Traumatic Coagulopathy. JOURNAL OF CLINICAL RESEARCH, 2023, 40(1): 78-80.
[1] COHEN J,SCORER T,WRIGHT Z,et al.A prospective evaluation of thromboelastometry (ROTEM) to identify acute traumatic coagulopathy and predict massive transfusion in military trauma patients in Afghanistan[J].Transfusion,2019,59(2):1601-1607. [2] 沈哲源,田书委,孔宇,等.创伤性凝血病发病机制及诊治研究进展[J].中华创伤杂志,2018,34(4):377-384. [3] 李雪,侯子琪,李盛华,等.原发性干燥综合征中高迁移率族蛋白1与免疫失衡的研究进展[J].中华微生物学和免疫学杂志,2020,40(4):311-315. [4] 何静,王军,杨涛.静脉血栓栓塞症患者外周血嗜酸性粒细胞与血小板、凝血功能指标、C-反应蛋白的相关性分析[J].中国普通外科杂志,2018,27(12):1531-1538. [5] 王君,白颖,周宁,等.创伤性凝血病发生的危险因素及其对多发创伤患者预后的影响[J].临床急诊杂志,2018,19(2):113. [6] 朱星星,张红,尚福泰,等.胰岛素强化治疗对重度颅脑损伤应激性高血糖患者HMGB1/NF-κB通路的影响[J].中华危重病急救医学,2019,31(8):949-952. [7] 修光辉,熊伟,尹云玉,等.HMGB1-RAGE/TLRs-NF-κB信号通路在骨髓间充质干细胞移植治疗内毒素致凝血功能障碍大鼠中的作用[J].中华危重病急救医学,2018,30(9):830-835. [8] GHADHBAN B R.Plasma d-dimer level correlated with advanced breast carcinoma in female patients[J].Ann Med Surg,2018,36(1):75-78. [9] 曾庆波,宋景春,杨洋,等.创伤患者血小板功能障碍对预后判断的临床价值[J].医学研究生学报,2019,32(8):845-849. [10] HENSKENS Y M C,GULPEN A J W,Oerle R,et al.Detecting clinically relevant rivaroxaban or dabigatran levels by routine coagulation tests or thromboelastography in a cohort of patients with atrial fibrillation[J].Thromb J,2018,16(1):3-11. [11] 朱悚之.人纤维蛋白原对急诊外伤致创伤性凝血病疗效及相关因素分析[J].中国临床药理学与治疗学,2019,24(6):693-698. [12] 徐杰.多发伤患者发生创伤性凝血病的危险因素及预后分析[J].中国基层医药,2018,25(9):1188-1192.
2023, Vol. 40 
