Abstract：【Objective】To explore the application value of Nicorandil in elderly patients with acute myocardial infarction and diabetes after percutaneous coronary intervention (PCI). 【Methods】The clinical data of 98 elderly patients with acute myocardial infarction and diabetes treated by PCI were retrospectively analyzed. They were divided into the observation group (routine treatment+Nicorandil) and the control group (routine treatment) according to whether they took Nicorandil or not, with 49 cases in each group.The blood flow grades of myocardial infarction thrombolysis test (TIMI), creatine kinase isoenzyme (CK-MB) and troponin I (cTnI) before and 24 hours after operation were compared between the two groups;The left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), and postprandial blood glucose (2hPG) of the two groups were also compared before and after treatment.The patients were followed up for 6 months to record the adverse cardiac events.【Results】The TIMI blood flow grading in the observation group was better than that in the control group, with a statistically significant difference (P<0.05). At 24 hours after operation, CK-MB and cTnI in the two groups were higher than those before operation, but those in the observation group were lower than those in the control group (P<0.05). LVEF after treatment was significantly higher than that before treatment, LVESD and LVEDD were significantly lower than that before treatment (P<0.05), and the difference between the observation group and the control group was statistically significant (P<0.05). After treatment, HbA1c, FPG and 2hPG in the two groups were lower than those before treatment (P<0.05), but there was no significant difference between the observation group and the control group (P>0.05). The total incidence of adverse cardiac events in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】Nicorandil can improve microcirculation perfusion, alleviate myocardial injury, improve cardiac function and reduce adverse cardiac events in elderly patients with acute myocardial infarction and diabetes after PCI.
李红, 李海燕. 尼可地尔用于老年急性心肌梗死合并糖尿病患者PCI术后的价值[J]. 医学临床研究, 2022, 39(12): 1819-1822.
LI Hong, LI Hai-yan. Value of Nicorandil after PCI in Elderly Patients with Acute Myocardial Infarction and Diabetes. JOURNAL OF CLINICAL RESEARCH, 2022, 39(12): 1819-1822.
2022, Vol. 39 
