Abstract：【Objective】 To investigate the expression and clinical significance of matrix metalloproteinase-9 (MMP-9) and endothelin-1 (ET-1) in diabetic cataract lens epithelial cells. 【Methods】From March 2019 to April 2021, 131 cataract patients accepted in the ophthalmology department of Xianyang First People's Hospital were collected as the research group. According to whether the patients were complicated with diabetes, they were divided into the non-diabetic cataract group of 31 cases and the diabetic cataract group of 100 cases. In addition, 83 cases of ocular trauma requiring removal of the normal transparent lens due to trauma accident were recruited as the control group. The expression of MMP-9 and ET-1 was detected by immunohistochemistry. The correlation of MMP-9 and ET-1 expression in lens epithelial cells of patients with diabetic cataract clinical indicators was analyzed by Spearman method. The related factors affecting diabetic cataract were analyzed by Logistic regression. 【Results】Compared with the control group, the positive expression of MMP-9 and ET-1 in the lens epithelial cells of the non-diabetic cataract group was obviously increased (P<0.05); compared with the non-diabetic cataract group, the positive expression of MMP-9 and ET-1 in the diabetic cataract group was increased (P<0.05). The results of Spearman analysis showed that the expression of MMP-9 and ET-1 was positively associated with fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), hemoglobin A1C (HbA1c), high sensitive C-reactive protein (hs-CRP) and malondialdehyde (MDA) (P<0.05), and they were negatively correlated with high-density lipoprotein cholesterol (HDL-C), apolipoprotein A (apoA), superoxide dismutase (SOD) and glutathione (GSH) (P<0.05). Multivariate logistic regression analysis showed that the positive expression of MMP-9 and ET-1 were risk factors for the occurrence of diabetic cataract (P<0.05). 【Conclusion】The expression of MMP-9 and ET-1 in lens epithelial cells of patients with diabetic cataract is increased, which are related to the occurrence of diabetic cataract.
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2022, Vol. 39 
