Abstract：【Objective】To investigate the effect of atorvastatin on the pathological changes of aortic valve induced by hyperlipidemia in rabbits. 【Methods】 A total of 39 healthy male New Zealand white rabbits were selected and divided into atorvastatin intervention diet high fat group (AI group), normal diet control group (N group) and simple high fat diet group (HC group) according to random number table. At 4, 8 and 12 weeks after the start of the experiment, venous blood was taken to measure the plasma lipid level, and aortic valve echocardiography was performed at 8 and 12 weeks after the start of the experiment. The morphological changes of valves in each group were analyzed, and the aortic valve markers were taken for histological examination. 【Results】 The levels of serum total cholesterol (TC), C-reactive protein (CRP), triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) in the group HC were significantly higher than those in the group AI and the group N (P<0.05); The levels of serum TC, TG, CRP and LDL-C in the group AI at 8 and 12 weeks were higher than those in the group N and lower than those in thegroup HC (P<0.05). At 12 weeks, the echocardiographic aortic valve in the group HC showed thickening and echo enhancement, and with the prolongation of high-fat diet, there was a tendency of valve calcification and decreased activity; Echocardiographic valve changes in the group AI were less severe than those in the group HC; There was no significant change in the group N before and after echocardiography. HE staining of aortic valve in the group HC showed endothelial injury, deposition of lipid calcium salt, growth of fibrous tissue and inflammatory reaction caused by macrophage infiltration; The pathological changes in the group AI were less severe than those in the group HC. 【Conclusion】 Atorvastatin can significantly delay the process of aortic valve disease induced by hyperlipidemia.
师闯, 李继勇, 王坡, 房磊, 金琪琳. 阿托伐他汀钙对高脂血症兔模型主动脉瓣膜病理改变的影响[J]. 医学临床研究, 2022, 39(9): 1295-1298.
SHI Chuang, LI Ji-yong, WANG Po, et al. Effect of Atorvastatin on Pathological Changes of Aortic Valve in the Model of Hyperlipidemia Rabbits. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1295-1298.
2022, Vol. 39 
