Abstract：【Objective】To investigate the therapeutic effect of Huazhirougan granules on regofinil targeted therapy of middle and advanced liver cancer patients with damp heat accumulation type.【Methods】A total of 110 patients with damp-heat accumulation type mid-advanced liver cancer admitted to the hospital were randomly divided into two groups. The control group was given symptomatic supportive treatment such as liver protection, antiemetic and leukocytes elevation on the basis of targeted therapy of regorafenil, while the observation group was given Huazhirougan granules treatment on the basis of administration in the control group. The Chinese medicine syndrome scores of damp-heat accumulation type (refer to the evaluation guidelines for clinical research of traditional Chinese medicines), ALT and AST levels,serum carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP)before treatment and 3 months after the treatment were recorded and compared between the two groups. The adverse drug reactionsin both groups were compared as well.【Results】Before treatment, there were no statistically significant differences in terms of all parameters between the two groups (P>0.05).After 3 months of treatment, the scores of the Chinese medicine syndrome (TCM) scores of damp-heat accumulation type were decreased in both groups (P<0.05), and those indicators in the observation group was lower than those in the control group (P<0.05).The ALT and AST levels in the control group were increased (P<0.05), while ALT and AST levels in the observation group did not obvious changes,which were lower than the control group (P<0.05). The total remission rate of the observation group was higher than that of the control group (P<0.05). There were no significant difference in CEA levels between the two groups after 3 months of treatment (P>0.05).The levels of AFP were decreased in both groups (P<0.05), however,AFP level in the observation group was lower than that in the control group (P<0.05).There were no statistically significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). 【Conclusion】Huazhirougan granules used for regorafenil targeted treatment of mid-advanced liver cancer patients with damp-heat accumulation type can improve their clinical symptoms, have a protective effect on liver function, regulate tumor marker levels and reduce regorafenil-induced fatigue.
马俊荣, 张奎. 化滞柔肝颗粒在瑞戈非尼靶向治疗湿热蕴结型中晚期肝癌患者中的效果[J]. 医学临床研究, 2022, 39(4): 510-513.
MA Jun-rong, ZHANG Kui. Efficacy of Huazhirougan Granules on Regofinil Targeted Therapy of Middle and Advanced Liver Cancer Patients with Damp Heat Accumulation Type. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 510-513.
2022, Vol. 39 
