Abstract：【Objective】 To investigate the effects of modified Shenqi Dihuang Decoction combined with alprostadil on renal function, inflammatory indexes and the level of advanced protein oxidation products (AOPP) in patients with chronic renal failure. 【Methods】 A total of 100 patients with chronic renal failure treated in our hospital were randomly divided into traditional Chinese medicine group (50 cases) and Western medicine group (50 cases). The western medicine group was treated with alprostadil, and the traditional Chinese medicine group was treated with modified Shenqi Dihuang Decoction combined with alprostadil. The changes of renal function [serum creatinine (SCR), urea nitrogen (BUN), 24h urinary protein], AOPP level, inflammatory indexes [C-reactive protein (CRP), interleukin-17 (IL-17), interleukin-6 (IL-6)] and clinical efficacy and adverse reactions were compared between the two groups. 【Results】 Compared with before treatment, serum SCR, BUN, 24h urinary protein, AOPP, CRP, IL-17 and IL-6 decreased significantly in the two groups after treatment (P<0.05), and the decrease in the traditional Chinese medicine group was more obvious than that in the western medicine group (P<0.05); The total effective rate of traditional Chinese medicine group was 86.00% (43/50), which was significantly higher than that of Western medicine group [62.00% (31/50) (P<0.05)]; There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 The modified Shenqi Dihuang Decoction combined with alprostadil in the treatment of chronic renal failure can effectively regulate the inflammatory indexes, reduce the level of AOPP, improve renal function and oxidative stress, and is safe and effective.
马浩, 王春丽, 张慧敏, 强昂. 加味参芪地黄汤联合前列地尔治疗慢性肾衰竭患者的疗效[J]. 医学临床研究, 2022, 39(5): 756-758.
MA Hao, WANG Chun-li, ZHANG Hui-min, et al. Effect of Modified Shenqi Dihuang Decoction Combined with Alprostadil on Patients with Chronic Renal Failure. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 756-758.
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2022, Vol. 39 
