Clinical Efficacy and Safety of Caffeine Citrate Combined with Noninvasive Respiratory Support in the Treatment of Neonatal Severe Aspiration Pneumonia
Abstract：【Objective】 To investigate the clinical efficacy and safety of caffeine citrate combined with noninvasive respiratory support in the treatment of neonatal severe aspiration pneumonia. 【Methods】 A total of 70 newborns with severe aspiration pneumonia treated in our hospital from June 2018 to April 2020 were prospectively selected and randomly divided into observation group (caffeine citrate combined with nasal continuous positive airway pressure ventilation,n= 34) and control group (caffeine citrate combined with nasal synchronous intermittent positive pressure ventilation,n= 36). The indexes of pulmonary function, respiratory mechanics and serum insulin-like growth factor binding protein-3 (IGFBP-3) and β- Endorphins(β- EP) were compared between the two groups,and the incidence of complications were also compared. 【Results】 After treatment, tidal volume (TV), peak time ratio (TPTEF/TE), peak volume ratio (VPEF/VE) and peak expiratory flow rate (PEF) in the two groups were higher than those before treatment (P<0.05), respiratory rate (RR), functional residual capacity (FRC) and effective airway resistance were lower than those before treatment (P<0.05), and there were significant differences between the observation group and the control group (P<0.05); The oxygenation index and lung compliance of the two groups were higher than those before treatment (P<0.05), and the inspiratory resistance was lower than that before treatment (P<0.05). There was significant difference between the observation group and the control group (P<0.05); The level of serum IGFBP-3 in the two groups was higher than that before treatment, and the level of β- EP was lower than that before treatment (P<0.05), and there was significant difference between the observation group and the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05).【Conclusion】 Caffeine citrate combined with noninvasive respiratory support model in the treatment of neonatal severe aspiration pneumonia can improve the indexes of pulmonary function and respiratory mechanics, and regulate serum IGFBP-3 and β- EP level, but transnasal synchronous intermittent positive pressure ventilation is better than transnasal continuous positive airway pressure ventilation.
张粉霞, 冯成虎, 吴晓玉, 张龙, 屈菊梅, 常祎, 赵新. 枸橼酸咖啡因联合无创呼吸支持模式治疗新生儿重症吸入性肺炎的临床疗效及安全性[J]. 医学临床研究, 2022, 39(4): 524-527.
ZHANG Fen-xia, FENG Cheng-hu, WU Xiao-yu, et al. Clinical Efficacy and Safety of Caffeine Citrate Combined with Noninvasive Respiratory Support in the Treatment of Neonatal Severe Aspiration Pneumonia. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 524-527.
2022, Vol. 39 
