Abstract：【Objective】 Objective to investigate the correlation between serum high sensitivity C-reactive protein (hs CRP), soluble growth stimulating gene 2 protein (sST2) and the condition and prognosis of patients with acute coronary syndrome (ACS).【Methods】 Sixty patients with ACS were selected as ACS group, and 60 healthy people were selected as control group. The serum hs CRP and sST2 levels of the two groups were detected, and the receiver operating characteristic curve (ROC) was drawn to analyze their predictive value for ACS. Pearson linear correlation was used to analyze the correlation between serum hs CRP, sST2 levels and grace. According to the prognosis of ACS patients, they were divided into good prognosis group and poor prognosis group. The serum hs CRP and sST2 levels of the two groups were compared, and the predictive value of the two groups for the prognosis of patients was analyzed. 【Results】 The serum hs CRP and sST2 in ACS group were higher than those in control group (P<0.05). The area under the curve of serum hs CRP and sST2 in predicting ACS was 0.648 and 0.746 respectively. When hs CRP>14.650 mg / L and sST2 > 15.275 ng / ml, the risk of ACS was higher. The grace score of ACS patients was (125.32±34.76). Pearson linear correlation analysis showed that serum hs CRP and sST2 were positively correlated with grace score (all P<0.05). Of the 60 patients with ACS, 15 had poor prognosis and 45 had good prognosis. The serum hs CRP and sST2 in poor prognosis group were significantly higher than those in good prognosis group (P<0.05). The area under the curve of serum hs CRP and sST2 in predicting poor prognosis of ACS was 0.676 and 0.694 respectively. When hs CRP>15.420 mg/L and sST2 > 23.500 ng/mL, the risk of poor prognosis of ACS was higher.【Conclusion】 Serum hs CRP and sST2 have a certain predictive value for ACS. They are positively correlated with grace score of ACS patients, and can be used as important indicators to predict the prognosis of ACS patients.
李进, 王卫卫. 血清hs-CRP和sST2与急性冠脉综合征患者病情及预后的相关性[J]. 医学临床研究, 2021, 38(5): 713-716.
LI Jin, WANG Wei-wei. Correlation of Serum hs CRP and sST2 with the Condition and Prognosis of Patients with Acute Coronary Syndrome. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 713-716.
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2021, Vol. 38 
