Abstract：【Objective】 To investigate the effect of transverse abdominal fascia block on postoperative pain and liver and kidney function in patients with liver cancer.【Methods】 A total of 90 patients with liver cancer who received surgical treatment in our hospital from July 2017 to July 2020 were selected and randomly divided into observation group (n=45) and control group (n=45). The control group was given rest combined with general anesthesia, and the observation group was given transverse abdominal fascia block.Visual analogue scale (VAS), C-reactive protein (CRP) and tumor necrosis factor -α(TNF-α),Interleukin-6 (IL-6), aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), blood urea nitrogen (BUN) and serum creatinine (SCR) were measured and compared between the two groups at different time points after treatment ; The incidence of liver insufficiency, ascites, and wound healing were recorded.【Results】 The VAS scores at 4 h, 8 h, 12 h and 24 h after operation in the observation group were lower than those in the control group (P<0.05); The levels of CRP and TNF-αand IL-6 in the two groups immediately after operation were higher than those before operation; The levels of CRP, TNF -αand IL-6 at 4 h and 24 h after operation in the observation group were significantly lower than those in the control group. The expression levels of AST and ALT in the two groups immediately after operation, 4 h and 24 h after operation were higher than those before operation, and the observation group was lower than the control group, the differences were statistically significant (P<0.05); There was no significant difference in ALB expression between the two groups at each time point (P>0.05). BUN and SCr were increased and then decreased in the two groups immediately after operation, 4 h after operation and 24 h after operation, and the expression level in the observation group was lower than that in the control group (P<0.05). During the treatment, the total incidence of liver insufficiency, ascites, wound healing and other complications in the observation group was lower than that in the control group (6.67% vs 26.67%), the difference was significant (P<0.05).【Conclusion】 Transverse abdominal fascia block has significant analgesic effect in patients with liver cancer surgery, which can reduce the level of inflammatory cytokines, protect the liver and kidney function of patients, and is conducive to the rapid recovery of patients after surgery.
何爱梅. 腹横筋膜阻滞对肝癌手术患者术后疼痛及肝肾功能的影响[J]. 医学临床研究, 2021, 38(5): 709-712.
HE Ai-mei. Effect of Transverse Abdominal Fascia Block on Postoperative Pain, Liver and Kidney Function in Patients with Hepatocellular Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 709-712.
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2021, Vol. 38 
