原发性硬化性胆管炎患者血清LBP和sCD14水平及与预后的关系

doi:10.3969/j.issn.1671-7171.2021.04.020

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摘要 【目的】 探讨原发性硬化性胆管炎(PSC)患者血清脂多糖结合蛋白(LBP)和可溶性CD14(sCD14)水平及与预后的关系。【方法】 选取2009年1月至2015年1月本院收治的87例PSC患者作为研究对象,采用酶联法检测患者血清LBP及sCD14水平,分析两者与PSC患者预后的关系。【结果】 87例PSC患者预后不良发生率为40.23%(35/87),35例预后不良患者中肝衰竭11例(12.64%),进展为肝胆管癌8例(9.20%),继发性胆汁性肝硬化12例(13.79%),死亡4例(4.60%)。预后不良组患者血清LBP及sCD14水平均明显高于预后良好组,且差异均有显著性(P<0.01)。Logistic多因素回归分析显示血清白蛋白(ALB)、总胆红素(TBIL)、血清白介素-8(IL-8)、LBP及sCD14与PSC患者预后密切相关(P<0.05)。模型C评估PSC患者预后的AUC高于模型A及模型B,且差异均有显著性(P<0.05)。【结论】 血清LBP及sCD14与PSC患者预后相关,检测血清LBP及sCD14有助于评估PSC患者预后情况。

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	李知翰
	张西亮

关键词 ：胆管炎, 硬化性, 载体蛋白质类/血液, 抗原, CD14/血液, 预后

Abstract：【Objective】 To investigate the serum levels of lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) in patients with primary sclerosing cholangitis (PSC) and their relationship with prognosis. 【Methods】 87 patients with PSC from January 2008 to January 2014 were selected as the study subjects. The serum levels of LBP and sCD14 were measured by ELISA, and the relationship between them and the prognosis of patients with PSC was analyzed. 【Results】 The incidence of poor prognosis was 40.23% (35/87) in 87 patients with PSC, including 11 cases of liver failure (12.64%), 8 cases of hepatobiliary carcinoma (9.20%), 12 cases of secondary biliary cirrhosis (13.79%) and 4 cases of death (4.60%). The serum levels of LBP and sCD14 in patients with poor prognosis were higher than those in patients with good prognosis (P<0.05). Logistic multivariate regression analysis showed that ALB, TBIL, IL-8, LBP and sCD14 were closely related to the prognosis of PSC patients (P<0.05). The A UC of model C in evaluating the prognosis of PSC patients was higher than that of model A and model B (P<0.05). 【Conclusion】 Serum LBP and sCD14 are correlated with the prognosis of patients with PSC. Detection of serum LBP and sCD14 is helpful to evaluate the prognosis of patients with PSC.

Key words： Cholangitis, Sclerosing Carrier Proteins/BL Antigens, CD14/BL Prognosis

收稿日期: 2019-08-28

中图分类号:

R575.7

引用本文:

李知翰, 张西亮. 原发性硬化性胆管炎患者血清LBP和sCD14水平及与预后的关系[J]. 医学临床研究, 2021, 38(4): 549-552.
LI Zhi-han, ZHANG Xi-liang. Serum Levels Of Lbp and Scd14 in Patients with Primary Sclerosing Cholangitis and Their Relationship with Prognosis. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 549-552.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.04.020 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I4/549

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