Abstract：【Objective】To investigate the expression and significance of Nrf2 in endometrioid adenocarcinoma. 【Methods】From January 2012 to December 2015, 5 cases of normal endometrium, 12 cases of endometrial hyperplasia, 11 cases of endometrial atypical hyperplasia and 26 cases of endometrioid adenocarcinoma were collected in the Department of pathology of our hospital. The expression level of Nrf2 in each tissue was detected by immunohistochemical method, and its clinical significance was analyzed. 【Results】 The high expression rate of Nrf2 in endometrioid adenocarcinoma, endometrial hyperplasia, atypical hyperplasia and normal endometrium was 88.5% (23/26), 66.7% (8/12), 63.6% (7/11) and 40% (2/5), respectively. The high expression rate of Nrf2 in endometrioid adenocarcinoma was significantly higher than that in normal endometrium, and the difference was statistically significant(χ2=6.31,P<0.05); There was no significant difference in the high expression rate between the other groups (mean P>0.05). The high expression rate of Nrf2 was not related to the age, stage, grade, tumor thrombus in vessels and the depth of myometrial invasion (mean P>0.05), but related to lymph node metastasis (P<0.05). 【Conclusion】 Nrf2 is overexpressed in endometrioid adenocarcinoma, which may play a role in promoting the occurrence, development and metastasis of endometrioid adenocarcinoma.
2021, Vol. 38 
