ST段抬高型心肌梗死老年患者血清维生素D结合蛋白水平与cTnT、BNP水平和SYTNAX评分的相关性分析

doi:10.3969/j.issn.1671-7171.2020.11.032

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摘要【目的】探讨ST段抬高型心肌梗死(STEMI)患者血清维生素D结合蛋白(VDBP)水平与SYTNAX评分、心肌肌钙蛋白T(cTnT)和B型脑钠肽(BNP)的相关性。【方法】选择2017年1月至2020年1月本院收治的168例老年STEMI患者的临床资料(观察组),选择同时期在本院体检的健康志愿者50例(对照组)。根据SYNTAX评分将观察组患者分为高危组、中危组、低危组,比较研究对象一般临床资料及血清低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)、VDBP、BNP、cTnT水平。Pearson相关法分析VDBP水平与cTnT、BNP和SYTNAX评分的相关性。【结果】观察组吸烟、高血压和糖尿病比例高于对照组,血清cTnT、BNP、VDBP、LDL-C水平高于对照组,差异有统计学意义(P<0.05)。三组受试者吸烟、高血压和糖尿病比例比较,差异无统计学意义(P>0.05)。高危组、中危组和低危组患者血清cTnT、BNP、VDBP水平比较,差异有统计学意义(P<0.05)。经pearson相关分析结果显示,VDBP水平与cTnT水平呈正相关(r=0.599,P<0.001),与BNP水平呈正相关(r=0.699,P<0.001),与SYTNAX评分呈正相关(r=0.613,P<0.001)。【结论】VDBP在STEMI患者中的表达水平明显增高,且与cTnT、BNP水平和SYTNAX评分呈正相关,据此可为STEMI的诊断及患者冠状动脉病变程度的评估提供一定参考。

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关键词 ： ST段抬高型心肌梗死/并发症, 急性病, 维生素D结合蛋白质/血液, 肌钙蛋白T/血液, 利钠肽, 脑/血液, 老年人

Abstract：【Objective】To detect the level of vitamin D binding protein (VDBP) in ST-segment elevation myocardial infarction (STEMI) patients, and further analyze the relationship of VDBP with SYTNAX score, cardiac troponin (cTnT) and B-type brain natriuretic peptide (BNP).【Methods】A total of 168 patients with acute ST-segment elevation myocardial infarction who were treated in our Department of Cardiology from January 2017 to January 2020 were selected in the observation group ; and 50 healthy volunteers were enrolled in the control group. According to the SYNTAX score, the observation group was further divided into the high-risk group, intermediate-risk group, and low-risk group. General clinical data were collected and various biochemical indicators were measured (Hexokinase activity assay kit for LDL-C level, BNP-Ⅱ assay kit for BNP, Roche Troponic-Ⅰ-HS kit for cTnT, enzyme-linked immunosorbent assay for measuring TC,TG and VDBP levels).Pearson correlation analysis examined the association of VDBP level with cTnT, BNP, and SYTNAX scores. 【Results】There were no significant differences in gender, age, BMI and biochemical markers (TC, TG and LDL-C) between the control group and the STEMI group (P>0.05). The number of smoking, hypertension and diabetes in the STEMI group was significantly higher than that in the control group. The levels of cTnT, BNP,LDL-C and VDBP in the STEMI group were higher than those in the control group (P<0.05).Patients were divided into three grades according to the SYNTAX score, 32 in the high-risk group, 84 in the intermediate-risk group, and 52 in the low-risk group. There was no difference in the proportion of smoking, hypertension and diabetes among the three groups (P>0.05). The differences of cTnT, BNP and VDBP levels among the high-risk group, the intermediate-risk group and the low-risk group were statistically significant (P<0.05).The Pearson correlation analysis showed that the expression level of VDBP was positively related to cTnT (r=0.599, P<0.001), BNP (r=0.699, P<0.001) and SYTNAX score (r=0.613, P<0.001). 【Conclusion】The expression level of VDBP in patients with STEMI is significantly increased, and it is positively correlated with cTnT, BNP and SYTNAX score. It can provide some help for the diagnosis of STEMI and the assessment of the degree of coronary artery disease.

Key words： ST Elevation Myocardial Infarction/CO Acute Disease Vitamin D-Binding Protein/BL Troponin T /BL Natriuretic Peptide, Brain /BL Aged

收稿日期: 2020-08-12

PACS:

R542.22

引用本文:

程荣, 赵建国, 黎小林, 陈礼龙, 张建平, 张岚. ST段抬高型心肌梗死老年患者血清维生素D结合蛋白水平与cTnT、BNP水平和SYTNAX评分的相关性分析[J]. 医学临床研究, 2020, 37(11): 1704-1707.
CHENG Rong, ZHAO Jian-guo, LI Xiao-lin, et al. Correlation of Vitamin D Binding Protein Level with cTnT, BNP and SYTNAX Score in Patients with ST-segment Elevation Myocardial Infarction. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1704-1707.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.11.032 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I11/1704

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