Abstract：【Objective】To investigate the predictive value of combined detection of urinary microalbumin (mALB), homocysteine (Hcy) and neutrophil gelatinase associated lipocalin (NGAL) in acute cerebral infarction with renal injury.【Methods】Eighty patients with acute cerebral infarction treated in our hospital from February 2016 to December 2018 were divided into acute cerebral infarction combined with renal injury group (group A,n=47) and simple acute cerebral infarction group (group B,n=33) according to whether renal injury occurred. In addition, 35 healthy physical examinees in our hospital at the same time were selected as control group (Group C). The levels of urine MLB, serum Hcy and NGAL of the three groups were compared, and the positive detection rate of the above indexes on renal injury was analyzed. The correlation between the levels of urine MLB, serum Hcy and NGAL and acute cerebral infarction combined with renal injury was analyzed by linear regression. The predictive value of MLB, Hcy and NGAL on acute cerebral infarction combined with renal injury was analyzed by ROC curve.【Results】Urine mALB, serum Hcy and NGAL levels and positive detection rate in the group A were significantly higher than those in the group B and the group C (P<0.05). Linear regression analysis showed that mALB, Hcy and NGAL levels were significantly correlated with acute cerebral infarction complicated with renal injury (P<0.05). ROC analysis showed that the area under ACU detected by combined detection was larger than that by single detection, and the combined detection could improve the prediction sensitivity and specificity (P<0.05). 【Conclusion】The levels of urine mALB, serum Hcy and NGAL in patients with acute cerebral infarction complicated with renal injury were significantly increased, and they were positively correlated with renal injury. The combined detection of the three indexes has high value in the diagnosis of renal injury.
宫萍, 张伟, 孙易南, 胡佳宇. mALB、Hcy及NGAL联合检测在急性脑梗死合并肾损伤中的预测价值[J]. 医学临床研究, 2020, 37(6): 847-850.
GONG Ping, ZHANG Wei, SUN Yi-nan, et al. Predictive Value of Combined Detection of mALB, Hcy and NGAL in Acute Cerebral Infarction with Renal Injury. JOURNAL OF CLINICAL RESEARCH, 2020, 37(6): 847-850.
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2020, Vol. 37 
