医学临床研究
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医学临床研究  2020, Vol. 37 Issue (8): 1198-1200    DOI: 10.3969/j.issn.1671-7171.2020.08.024
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电视胸腔镜手术治疗高龄小结节非小细胞肺癌患者的临床效果
张亚年, 仲宁, 张璐
昆山市第一人民医院/江苏大学附属昆山医院,江苏 昆山 215300
Clinical Effect of VATS in the Treatment of Elderly snNSCLC Patients
ZHANG Ya-nian, ZHONG Ning, ZHANG Lu
Kunshan First People's Hospital. Kunshan 215300
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摘要 目的】 探讨电视胸腔镜手术(VATS)治疗高龄小结节非小细胞肺癌(snNSCLC)患者的临床效果。【方法】 回顾性分析2016年1月至2019年3月于本院行VATS治疗的120例高龄snNSCLC患者的临床资料,根据手术方法的不同将其分为观察组(行VATS治疗,n=62)和对照组(传统开胸肺叶切除术,n=58)。观察并记录观察组和对照组的手术时间、术中出血量和住院时间,比较两组血清皮质醇(Cor)、前列腺素E2(PGE2)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平。【结果】 观察组手术时间、出血量和术后引流量明显低于对照组,差异均有统计学意义(P<0.05);引流时间、淋巴结清扫数比较,差异无统计学意义(P>0.05)。术后3 d,观察组、对照组血清CRP、TNF-α、Cor、PGE2水平均显著高于术前(P<0.05);观察组血清CRP、TNF-α、Cor、PGE2水平明显低于对照组,差异有统计学意义(P<0.05)。两组术后复发及转移发生率比较差异无统计学意义(χ2=0.059,P=0.808>0.05),两组术后并发症发生率比较差异无统计学意义(χ2=1.201,P=0.273>0.05)。【结论】 VATS治疗高龄snNSCLC患者有较好的临床效果,患者应激反应及炎性反应较轻,安全性较好,值得临床推广使用。
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张亚年
仲宁
张璐
关键词 癌, 非小细胞肺/外科学老年人胸腔镜检查胸外科手术, 电视辅助    
Abstract:【Objective】 To investigate the clinical effect of video-assisted thoracoscopic surgery (VATS) in the treatment of elderly patients with small nodule non-small cell lung cancer (snNSCLC). 【Methods】 A total of 120 elderly patients with snNSCLC treated in our hospital from January 2016 to March 2019 were selected, the patients were divided into observation group (n=62) and observation group (n=58) according to the selected surgical scheme, the observation group was treated with VATS, while the control group was treated with traditional thoracotomy, the operation time and bleeding volume and so on were observed. 【Results】 The operation time, bleeding volume and drainage volume in the observation group were (180.64±23.34) min, (260.51±52.87) mL and (630.03±100.45) mL, which were significantly less than those in the control group (P<0.05); The levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), cortisol and prostaglandin E2 (PGE2) in the observation group at3 days after operation were (40.10±5.54) mg/L, (63.35 ±5.15) pg/mL, (120.05±25.54) ng/mL and (182.26±21.50) ng/mL, which were significantly lower than those in the control group (P<0.05);There were no significant difference in the incidence of complications, recurrence or metastasis between the observation group and the control group (P>0.05). 【Conclusion】 VATS has a good clinical effect in the treatment of elderly patients with snNSCLC, the patients'stress and inflammatory reaction are mild, which is worthy of clinical use.
Key wordsCarcinoma, Non-Small-Cell Lung/SU    Aged    Thoracoscopy    Thoracic Surgery, Video-Assisted
收稿日期: 2020-02-11     
PACS:  R730.26  
引用本文:   
张亚年, 仲宁, 张璐. 电视胸腔镜手术治疗高龄小结节非小细胞肺癌患者的临床效果[J]. 医学临床研究, 2020, 37(8): 1198-1200.
ZHANG Ya-nian, ZHONG Ning, ZHANG Lu. Clinical Effect of VATS in the Treatment of Elderly snNSCLC Patients. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1198-1200.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.08.024     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I8/1198
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