丁苯酞联合神经节苷脂静脉滴注对急性脑梗死患者神经功能及生活质量的影响

doi:10.3969/j.issn.1671-7171.2020.11.023

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摘要【目的】本研究探讨丁苯酞联合神经节苷脂静脉滴注对急性脑梗死患者神经功能及生活质量的影响。【方法】回顾性分析 2014年3月至2018年10月本院神经外科收治的126例急性脑梗死患者的临床资料,根据治疗药物的不同将其分为对照组(n=63,接受丁苯酞静脉滴注)与观察组(n=63,接受丁苯酞联合神经节苷脂静脉滴注治疗)。治疗15 d后,比较两组治疗后的神经功能NIHSS评分、日常生活能力Barthel评分,评估两组患者治疗疗效。检测比较两组治疗前后的血清神经元特异性烯醇化酶(NSE)、S100β蛋白、超氧化物歧化酶(SOD)、丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平。【结果】治疗15 d后,两组NIHSS评分均较治疗前下降,且观察组明显低于对照组,差异均具有统计学意义(P<0.05);两组Barthel评分均较治疗前提高,且观察组明显高于对照组,差异均具有统计学意义(P<0.05)。两组血清NSE、S100β、MDA、TNF-α及CRP水平均低于治疗前,且观察组各指标明显低于对照组,差异均有统计学意义(P<0.05);两组血清SOD水平均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组的总有效率为93.7%(59/63),明显高于对照组的76.2%(48/63),差异有统计学意义(P<0.05)。【结论】丁苯酞联合神经节苷脂静脉滴注能够改善急性脑梗死患者神经功能,促进神经功能恢复,改善生活质量,提高脑梗死治疗效果,其机制可能与减轻氧化应激和炎症损伤有关。

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	朱晓暾

关键词 ：脑梗死/药物疗法, 急性病, 苯丙酮类/药理学, 神经节苷脂类/药理学, 生活质量

Abstract：【Objective】To investigate the effect of Butylphthalide Combined with Ganglioside on preventing reperfusion injury and quality of life in patients with cerebral infarction. 【Methods】The clinical data of 126 patients with acute cerebral infarction admitted to the Department of Neurosurgery of our hospital from March 2014 to October 2018 were retrospectively analyzed. According to the different treatment drugs, they were divided into control group (n=63, receiving butylphthalide intravenous drip) and observation group (n=63, receiving butylphthalide combined with ganglioside intravenous drip). After 15 days of treatment, the NIHSS score of neurological function and Barthel score of activities of daily living of the two groups were compared to evaluate the therapeutic effect of the two groups. The serum levels of neuron specific enolase (NSE), S100 β protein, superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α(TNF-α), C-reactive protein (CRP) were detected and compared between the two groups before and after treatment. 【Results】After 15 days of treatment, the NIHSS scores of the two groups were decreased compared with those before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant (P<0.05); the Barthel scores of the two groups were improved, and the observation group was significantly higher than the control group, the differences were statistically significant (P<0.05). The levels of NSE, S100β, MDA, TNF-αand CRP in the two groups were lower than those before treatment, and the indexes in the observation group were significantly lower than those in the control group (P<0.05); the serum SOD levels in the two groups were higher than those before treatment, and the observation group was higher than the control group, the differences were statistically significant (P<0.05). After treatment, the total effective rate of the observation group was 93.7% (59/63), significantly higher than 76.2% (48/63) of the control group, the difference was statistically significant (P<0.05).【Conclusion】Butylphthalide combined with ganglioside intravenous drip can improve the neurological function of patients with acute cerebral infarction, promote the recovery of neurological function, improve the quality of life, and improve the therapeutic effect of cerebral infarction. The mechanism may be related to the reduction of oxidative stress and inflammatory injury.

Key words： Brain Infarction/DT Acute Disease Propiophenones/PD Gangliosides/PD Quality of Life

收稿日期: 2018-11-21

PACS:

R743.33

引用本文:

朱晓暾. 丁苯酞联合神经节苷脂静脉滴注对急性脑梗死患者神经功能及生活质量的影响[J]. 医学临床研究, 2020, 37(11): 1674-1677.
ZHU Xiao-dun. Effect of Butylphthalide Combined with Ganglioside Intravenous Drip on Neurological Function and Quality of Life in Patients with Acute Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1674-1677.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.11.023 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I11/1674

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