Abstract：【Objective】 To investigate the correlation between serum Vaspin level and severity of coronary heart disease (CHD). 【Methods】 A total of 120 patients with CHD in our hospital from January 2015 to December 2017 were selected as the observation group and 60 healthy volunteers in the same period as the control group. Serum Vaspin, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FPG) were detected in the two groups. The correlation between serum vaspin and the severity of coronary artery disease was analyzed. The high-risk factors of CHD were analyzed by logistic regression.【Results】 The serum TG, TC, HDL-C, LDL-C and FPG of the observation group were significantly higher than those of the control group, and the serum Vaspin level was lower than that of the control group (P<0.05). The serum Vaspin level of moderate stenosis group and severe stenosis group was lower than that of the mild stenosis group, and that of the severe stenosis group was lower than that of the moderate stenosis group (F=22.198, P<0.05). The Gensini score of the observation group was (60.55 ± 13.91), and there was a significant negative correlation between serum vaspin and Gensini score (r=-0.692, P<0.05). Logistic regression analysis showed that the decrease of serum Vaspin and HDL-C levels, and the increase of TC, TG and LDL-C levels were the independent risk factors for CHD (P<0.05).【Conclusion】 The serum Vaspin level was significantly lower in CHD patients, and the serum vaspin level is negatively correlated with the severity of coronary artery disease in CHD patients.
2020, Vol. 37 
