Abstract:【Objective】 To investigate the application value of microcatheter ipsilateral double angiography in patients with chronic total occlusion (CTO) undergoing anterior percutaneous coronary intervention (PCI). 【Methods】 Retrospective analysis was made on the patients diagnosed as J-CTO by coronary angiography in our hospital from January 2018 to December 2019. All 30 patients were treated with forward technique, including 13 cases of ipsilateral double angiography with microcatheter (observation group), and 17 cases with routine bilateral angiography (control group). Coronary angiography, J-CTO score, X-ray exposure time, total PCI time, dosage of contrast agent, incidence of surgical complications, complications of arterial puncture, incidence of major adverse cardiovascular events (MACE) and secondary end-point events and ejection fraction (LVEF) were compared between the two groups.【Results】 There was no significant difference in J-CTO score, the number of coronary artery lesions, the proportion of left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA) between the two groups (P>0.05). There was no significant difference in X-ray exposure time, total PCI time, operation complications and artery puncture complications between the two groups (P>0.05). The dosage of contrast medium in the observation group was lower than that in the control group (P<0.05). There was no significant difference in MACE events, secondary end-point events and LVEF between the two groups 30 days after operation (P>0.05). 【Conclusion】 In the process of antegrade PCI Treatment of CTO lesions, the application of microcatheter ipsilateral dual angiography can better guide the process of PCI operation, and does not increase the difficulty of operation. At the same time, it can also reduce the use of contrast media and reduce the risk of complications of arterial puncture.