Effects of Danhong Injection on Coagulation and Fibrinolysis Function, Platelet Activation, Inflammatory Factors and Oxidative Stress after Emergency PCI
HU Zi-wei
Wuhan Central Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology, Hubei Wuhan, 430000
摘要【目的】探讨丹红注射液对急性心肌梗死(AMI)患者急诊经皮冠状动脉介入术(PCI)后凝血纤溶功能、血小板活化、炎症因子和氧化应激的影响。【方法】86例在本院行急诊PCI治疗的AMI患者,随机分为对照组和观察组。两组均给予常规西医治疗,在此基础上,观察组患者给予丹红注射液治疗,两组均连续治疗14d。观察两组PCI术前及术后14d凝血纤溶功能指标凝血酶时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D－二聚体(D-D);血小板活化功能指标溶酶体膜糖蛋白(CD63)、血小板α颗粒表面膜糖蛋白(CD62p)、单核细胞血小板聚集体(MPA);炎症因子指标C反应蛋白(CRP)、白介素-6(IL-6)以及氧化应激指标过氧化物歧化酶(SOD)、丙二醛(MDA)的变化;并比较两组治疗疗效。【结果】①观察组总有效率大于对照组(90.70％ vs 72.09％,P<0.05);②术前两组各指标差异均无显著性(P>0.05)。治疗后,两组凝血纤溶功能(APTT、PT、FIB、D-Dimer)较之前明显改善(P<0.05),且观察组改善程度优于对照组(P<0.05);③治疗后,两组血小板活化功能(CD63、CD62p、MPA)较治疗前明显降低,且观察组比同期对照组降幅更为显著(P<0.05);④治疗后,两组炎症因子(CRP、IL-6)较治疗前降低,且观察组比同期对照组降幅更为显著(P<0.05);⑤治疗后,两组氧化应激(SOD、MDA)指标较治疗前明显改善,且观察组改善程度优于对照组(P<0.05)。【结论】急诊PCI术后患者应用常规西药联合丹红注射液可明显提高临床疗效,降低血液黏度、改善血流动力学,抑制免疫炎性及氧化应激反应,从而稳定动脉粥样斑块,改善患者预后。
Abstract：【Objective】 To investigate the effects of Danhong injection on coagulation and fibrinolysis function, platelet activation, inflammatory factors and oxidative stress after emergency percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). 【Methods】A total of 86 patients with AMI who underwent emergency PCI treatment in our hospital were randomly divided into two groups: the observation group and the control group. The patients in the two groups were continuously treated for 14 days with conventional western medicine, while patients in the observation group received Danhong injection. The coagulation and fibrinolytic function: thrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and D-dimer (DD), platelet activation function: Lysosomal membrane glycoprotein (CD63), platelet alpha granule surface membrane glycoprotein (CD62p), monocyte platelet aggregates (MPA), inflammatory factor indicators: C-reactive protein (CRP), interleukin-6 (IL-6) ) and oxidative stress indicators: peroxidase dismutase (SOD) and malondialdehyde (MDA) were observed before PCI and 14 days after PCI and compared between the two groups. 【Results】 ①The total effective rate of the observation group was higher than that of the control group (90.70% vs 72.09%, respectively, P<0.05).②There was no significant difference in coagulation and fibrinolysis function between the two groups before treatment (P>0.05).After treatment, the coagulation and fibrinolysis function (APTT,PT,FIB and D-Dimer) of the two groups was improved obviously; and the improvement degree of the observation group was better than that of the control group (P<0.05).③After treatment, the platelet activation function (CD63,CD62p and MPA) in the two groups was significantly lower than that before treatment; and the decrease in the observation group was more significant than that in the control group (P<0.05).④After treatment, the levels of inflammatory factors (CRP and IL-6) in the two groups were both lower than before; and the decrease in the observation group was more significant than that in the control group at the same time (P<0.05).⑤After treatment, the index of oxidative stress (SOD and MDA) in the two groups was obviously improved; and the degree of improvement in the observation group was better than that in the control group (P<0.05). 【Conclusion】Application of routine western medicine combined with Danhong injection after emergency PCI can significantly improve clinical efficacy, reduce blood viscosity, improve hemodynamics, inhibit immune inflammatory and oxidative stress response, and thus stabilize atherosclerotic plaques and improve the prognosis.
胡紫薇. 丹红注射液对急诊PCI术后凝血纤溶功能、血小板活化、炎症因子和氧化应激的影响[J]. 医学临床研究, 2020, 37(3): 350-353.
HU Zi-wei. Effects of Danhong Injection on Coagulation and Fibrinolysis Function, Platelet Activation, Inflammatory Factors and Oxidative Stress after Emergency PCI. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 350-353.
2020, Vol. 37 
