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医学临床研究  2020, Vol. 37 Issue (2): 196-198    DOI: 10.3969/j.issn.1671-7171.2020.02.011
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GAS5在子痫前期患者血清及胎盘组织中的表达及其意义
胡菲菲, 徐晓茜, 黄艳
深圳大学总医院妇产科,广东 深圳 518000
Expression and Significance of GAS5 in Serum and Placenta of Preeclampsia Patients
HU Fei-fei, XU Xiao-qian, HUANG Yan
Department of Gynaecology and obstetrics,Shenzhen university general hospital,Shenzhen,Guangdong 518000,China
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摘要 【目的】探讨生长停滞特异性蛋白5(GAS5)在子痫前期患者血清及胎盘组织中的表达及其意义。【方法】选择2015年1月至2017年12月在本院待产的子痫前期患者43例(观察组)和同期在本院待产的正常孕妇43例(对照组)。两组分娩前采集血清标本,产后收集胎盘标本。采用酶联免疫吸附试验检测血清GAS5水平;采用实时荧光PCR法检测GAS5 mRNA水平;采用SPSS Pearson相关性软件分析子痫前期发生率与患者血清GAS5、胎盘中GAS5水平的相关性。【结果】观察组子痫前期患者血清GAS5、胎盘组织中GAS5 mRNA水平分别为0.185±0.121、0.121±0.05,均显著低于对照组的0.332±0.036、0.452±0.019,其差异均有统计学意义(P<0.05);相关性分析显示:子痫前期患者血清GAS5、胎盘中GAS5 mRNA水平与子痫前期的发生率呈负相关(r=-0.693,P=0.038;r=-0. 712,P=0.027)。【结论】子痫前期患者血清GAS5及胎盘中GAS5 mRNA呈低表达,其表达与子痫前期的发病呈负相关,并可能参与子痫前期的发生、发展过程。
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胡菲菲
徐晓茜
黄艳
关键词 先兆子痫胎盘    
Abstract【Objective】To investigate the expression and significance of growth arrest specific protein 5 (gas5) in serum and placenta of preeclampsia patients.【Methods】From January 2015 to December 2017, 43 preeclampsia patients (observation group) and 43 normal pregnant women (control group) were selected. Serum samples were collected before delivery and placenta samples were collected after delivery. Enzyme linked immunosorbent assay was used to detect the level of serum GAS5, real-time PCR was used to detect the level of GAS5 mRNA, SPSS Pearson correlation software was used to analyze the correlation between the incidence of preeclampsia and the level of serum GAS5 and placental GAS5.【Results】The levels of serum GAS5 and placental GAS5 mRNA were 0.185±0.121 and 0.12±0.05 in the observation group, respectively, which were significantly lower than those in the control group (0.332±0.036 and 0.452±0.019, P<0.05). The correlation analysis showed that the levels of serum GAS5 and placental GAS5 mRNA were negatively correlated with the incidence of preeclampsia (r=-0.693,P=0.038;r=-0.712,P=0.027).【Conclusion】 Serum GAS5 and placental GAS5 mRNA in preeclampsia patients show low expression, its expression is negatively related to the pathogenesis of preeclampsia, and may be involved in the occurrence and development of preeclampsia.
Key wordsPre-Eclampsia    Placenta
收稿日期: 2019-01-09     
PACS:  R714.244  
基金资助:广东省科技计划项目课题(编号:20160059B201)
引用本文:   
胡菲菲, 徐晓茜, 黄艳. GAS5在子痫前期患者血清及胎盘组织中的表达及其意义[J]. 医学临床研究, 2020, 37(2): 196-198.
HU Fei-fei, XU Xiao-qian, HUANG Yan. Expression and Significance of GAS5 in Serum and Placenta of Preeclampsia Patients. JOURNAL OF CLINICAL RESEARCH, 2020, 37(2): 196-198.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.02.011     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I2/196
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