Abstract：【Objective】 To investigate correlation between serum glucose and lactate levels and prognosis in patients with aneurysmal subarachnoid hemorrhage. 【Methods】The clinical data of 71 patients with aneurysmal subarachnoid hemorrhage admitted to our hospital from February 2015 to January 2018 were retrospectively analyzed. According to the prognosis of patients with hemorrhagic subarachnoid hemorrhage, patients were classified into the poor prognosis group (n=27) and the good prognosis group (n=44). Serum glucose and blood lactate levels were measured in both groups. Logistic regression was used to analyze the independent influencing factors of patients with poor prognosis. The receiver operating characteristic curve (ROC) was used to analyze the efficacy of serum glucose (Glu), blood lactate (Lac) and combined detection in the diagnosis of poor prognosis in patients with aneurysmal subarachnoid hemorrhage. 【Results】The levels of bleeding, WBC, SCr, cTnI, Lac, and Glu in patients with poor prognosis were significantly higher than those in patients with good prognosis. The proportion of Hunt-Hess grade and hypertension in patients with poor prognosis was higher than that in patients with good prognosis. The difference was statistically significant (P<0.05). Logistic regression analysis showed that the amount of bleeding, levels of Lac, Glu, and WBC, and Hunt-Hess grading were risk factors for poor prognosis (P<0.05). Serum Glu level was positively correlated with mRS score and blood loss (r=0.678, 0.734, P<0.05). Serum Lac level was also positively correlated with mRS score and blood loss (r=0.681, 0.705, both P<0.05) The efficacy of serum glucose diagnosis in patients with poor diagnosis is higher than that of blood lactate. The combined detection of serum glucose and blood lactate is more effective than single indicator in predicting prognosis of aneurysmal subarachnoid hemorrhage. 【Conclusion】Serum glucose and blood lactate levels are closely related to poor prognosis in patients with aneurysmal subarachnoid hemorrhage, which can accurately assess the prognosis of patients. The detection of serum Lac and Glu levels is convenient and rapid, and has certain efficacy for diagnosis. The combined detection and diagnosis of patients with poor prognosis is more effective, which is of great significance for clinical diagnosis and treatment.
王燕艳, 陈涛, 胡德荣. 血清葡萄糖、乳酸水平与动脉瘤性蛛网膜下腔出血患者预后的相关性分析[J]. 医学临床研究, 2019, 36(7): 1323-1325.
WANG Yan-yan, CHEN Tao, HU De-rong. Correlation between Serum Glucose and Lactate Levels and Prognosis in Patients with Aneurysmal Subarachnoid Hemorrhage. JOURNAL OF CLINICAL RESEARCH, 2019, 36(7): 1323-1325.
[1] 张光绪, 马骏, 王成斌,等. 自发性蛛网膜下腔出血后早期脑损伤发生机制及实验性治疗研究进展[J]. 临床神经外科杂志, 2016, 13:474-477. [2] Witt AM, Larsen FS, Bjerring PN. Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity[J]. Metab Brain Dis, 2016, 32:461-470. [3] 中华医学会神经病学分会. 中国蛛网膜下腔出血诊治指南2015[J]. 中华神经科杂志, 2016, 49:182-191. [4] 王勇朝,田亚楠,王建宇,等.血清透明质酸水平预测急性期自发性脑出血患者预后的临床研究[J].国际神经病学神经外科学杂志,2017,44:128-131. [5] Park SD, Kim JH, Chang CH, et al. Procedure-related complication rate for the endovascular treatment of aneurysmal subarachnoid hemorrhage under local anesthesia[J]. J Cerebrovasc Endovasc Neurosurg, 2016, 18:215-222. [6] Qi Y, Liu Y, Bing L, et al. A prognostic model for early post-treatment outcome of elderly patients with aneurysmal subarachnoid hemorrhage[J]. World Neurosurg, 2016, 95:253-261. [7] Allwellbrown E. Correlation of the association of serum lactate, random blood sugar, and revised trauma score as predictors of outcome in hemodynamically unstable abdominal emergencies.[J]. Niger J Clin Pract, 2016, 19:196-200. [8] Román LS, Menon BK, Blasco J, et al. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data[J]. Lancet Neurol, 2018,17:895-904. [9] Choi S, Ettinger SL, Lin D, et al. TargetingMCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer[J]. Cancer Med, 2018, 7:3385-3392. [10] Sun S, Li H, Chen J, et al. Lactic acid: no longer an inert and end-product of glycolysis[J]. Physiology(Bethesda), 2017, 32:453-463.
2019, Vol. 36 
