Abstract：【Objective】To investigate the effects of metformin combined with liraglutide on islet α and β cells, cytokines and cellular immune function in patients with type 2 diabetes mellitus (T2DM).【Methods】From April 2016 to April 2017, 102 patients with T2DM were selected. According to the random table method, the patients were divided into observation group and control group with 51 cases in each group. The observation group was treated with metformin and liraglutide, the control group was treated only by metformin. The course of treatment was 12 weeks in both groups. Before and after treatment, the changes of FPG, 2hPG, HbA1c, HOMA-IR, HOMA-β, fasting glucagon (FGlg), IL-6, IGF-1, TNF-α, CD3+and CD4+CD4+/CD8+were compared between the two groups.【Results】After treatment, FPG, 2h PG and HbA1c in both groups were significantly lower than those before treatment (P<0.05). After treatment, HOMA-IR and FGlg decreased and HOMA-β increased in both groups (P<0.05). After treatment, HOMA-IR and FGlg in the observation group were lower than those in the control group, but HOMA-β was higher than that in the control group (P<0.05). After treatment, the level of IL-6, IGF-1, TNF-αdecreased in both groups (P<0.05). The level of IL-6, IGF-1 and TNF-αin the observation group was lower than that of the control group (P<0.05). CD4 and CD4/CD8 of CD8 were increased in both groups after treatment (P<0.05). The levels of CD3+, CD4+and CD4+/CD8+in the observation group were higher than those in the control group (t=10.8227、5.9040、7.1660, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】The curative effect of metformin combined with Lilaru peptide on T2DM patients is significant. It can improve the islets alpha and beta cells, cytokines and cellular immune functions of the patients, and is worthy of clinical application.
刘凌琳,章陈晨,熊玮. 二甲双胍联合利拉鲁肽对2型糖尿病患者胰岛α和β细胞、细胞因子及细胞免疫功能的影响[J]. 医学临床研究, 2018, 35(2): 222-225.
LIU Ling-lin, ZHANG Chen-chen, XIONG Wei. Effects of Metformin Combined with Liraglutide on Islet α and β Cells, Cytokines and Cellular Immune Function in Patients with T2DM. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 222-225.
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2018, Vol. 35 
