Clinical Effect of Lumbar Cistern Drainage Combined with 3H therapy in the Subarachnoid Hemorrhage after Aneurysm Clipping Operation and its Effect on Vasoactive Factors
Abstract：【Objective】 To study the clinical effect of lumbar cistern drainage combined with hypertension, high blood volume and hemodilution (3H) on subarachnoid hemorrhage after aneurysm clipping operation and its effect on vasoactive factors. 【Methods】 From May 2016 to May 2017, 116 patients with subarachnoid hemorrhage were randomly divided into two groups: the control group (n = 58) and the observation group (n=58). The control group was treated with lumbar cistern drainage after aneurysm clipping. The observation group combined with 3 H therapy on the basis of the control group. The therapeutic effects, postoperative complications, serum C-reactive protein (CRP) and S100 levels, plasma diastolic factor (NO), contraction factor (ET-1), thromboxane B2 (TXB2) and human 6-keto-prostacyclin (6-K-PGF1α) levels were compared between the two groups.【Results】 The effective rate of treatment in the observation group was 93.1%, which was significantly higher than that in the control group 70.4%(P<0.05); the headache score and cerebral vasospasm in the observation group were significantly lower than those in the control group (P<0.05), and the craniocerebral hydrocephalus and mortality were significantly lower than those in the control group (P<0.05). Before intervention, there was no significant difference in serum CRP,S100 level and plasma NO,ET-1,TXB2 and 6-K-PGF1α levels between the two groups (P>0.05), and after intervention, the indexes in the observation group were significantly lower than those in the control group (P<0.05).【Conclusion】 The treatment of subarachnoid hemorrhage by lumbar cistern drainage combined with 3H after aneurysm clipping is safe and reliable. It can reduce complications and ensure survival rate.
陈绍华. 动脉瘤夹闭术后腰大池引流联合3H治疗蛛网膜下腔出血的效果及对血管活性因子的影响[J]. 医学临床研究, 2018, 35(9): 1723-1726.
CHEN Shao-hua. Clinical Effect of Lumbar Cistern Drainage Combined with 3H therapy in the Subarachnoid Hemorrhage after Aneurysm Clipping Operation and its Effect on Vasoactive Factors. JOURNAL OF CLINICAL RESEARCH, 2018, 35(9): 1723-1726.
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2018, Vol. 35 
