Abstract：【Objective】 To evaluate and compare the safety and clinical efficacy of levosulpiride, domperidone and metoclopramide in the treatment of functional dyspepsia.【Methods】 One hundred and fifty patients with functional dyspepsia from June 2014 to March 2015 were randomly divided into three groups with 50 cases in each group. The three groups were treated with levosulpiride, domperidone and metoclopramide respectively. The degree of functional dyspepsia before and after treatment was evaluated by Leeds indigestion questionnaire and Likert five-point scale. 【Results】 143 of 150 patients (50 in the levosulpiride group, 45 in the domperidone group and 48 in the metoclopramide group) completed the test successfully. All three drugs can improve patients' symptoms of functional dyspepsia to varying degrees. However, the overall improvement of dyspepsia in the levosulpiride group was significantly higher than that in the other two groups (P<0.05), and the incidence of adverse reactions (including nausea, headache, diarrhea, etc.) was the lowest in the levosulpiride group.【Conclusion】 Levosulpiride has higher safety and efficacy than domperidone and metoclopramide in the treatment of functional dyspepsia.
魏铁军, 张恒, 郭艺静, 张永利, 姜萌, 白云磊. 左舒必利、多潘立酮和胃复安治疗功能性消化不良的安全性及疗效比较[J]. 医学临床研究, 2018, 35(12): 2332-2334.
WEI Tie-jun, ZHANG Heng, GUO Yi-jing, et al. Safety and Efficacy of Levosulpiride, Domperidone and Metoclopramide in the Treatment of Functional Dyspepsia. JOURNAL OF CLINICAL RESEARCH, 2018, 35(12): 2332-2334.
[1] 杨云生,彭丽华. 功能性胃肠病罗马诊断标准与研究现状[J].解放军医学院学报, 2013, 34(6):541-543. [2] 莫光英.功能性消化不良的治疗进展[J].中国实用医药, 2014,9 (3):251-252. [3] Suzuki H, Moayyedi P. Helicobacter pylori infection in functional dyspepsia and the introduction of the Rome III classification [J].J Gastroenterol,2006, 41(6):513-523. [4] Mearin F, Rey E, Balboa A.Motility and functional gastrointestinal disorders[J].Gastroenterol Hepatol,2014, 37(3):3-13. [5] Fraser A, Delaney BC,Ford AC,et al.The short-form leeds dyspepsia questionnaire validation study[J].Aliment Pharmacol Ther, 2007, 25(4):477-486. [6] Weber CK, Miqlioranza MH, Moraes MA, et al. The five-point Likert scale for dyspnea can properly assess the degree of pulmonary congestion and predict adverse events in heart failure outpatients[J].Clinics,2014, 69(5):341-346. [7] Oshima T, Miwa H. Epidemiology of functional gastrointestinal disorders in Japan and in the world[J].J Neurogastroenterol Motil,2015,21(3):320-329. [8] Zala AV, Walker MM, Talley NJ. Emerging drugs for functional dyspepsia[J].Expert Opin Emerg Drugs,2015, 20(2):221-233. [9] Mansi C,Borro P,Giacomini M,et al.Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis[J].Aliment Pharmacol Ther,2000,14(5):561-569. [10] 蒋敦科.有关胃复安致锥体外系反应研究[J].药物与人,2014, 27(5):309-310.
2018, Vol. 35 
